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Blood, Vol. 94 No. 8 (October 15), 1999:
pp. 2871-2879
Involvement of Interleukin-10 (IL-10) and Viral IL-6 in the Spontaneous
Growth of Kaposi's Sarcoma Herpesvirus-Associated Infected Primary
Effusion Lymphoma Cells
Karen D. Jones*,
Yoshiyasu Aoki*,
Yuan Chang,
Patrick S. Moore,
Robert Yarchoan, and
Giovanna Tosato
From the Division of Hematologic Products, Center for Biologics
Evaluation and Research, Food and Drug Administration, Bethesda, MD;
the Department of Pathology, School of Public Health, Columbia
University, New York, NY; and the HIV and AIDS Malignancy Branch,
National Cancer Institute, National Institutes of Health, Bethesda, MD.
Primary effusion lymphoma (PEL) is a distinct type of lymphoma
associated with Kaposi's sarcoma-associated herpesvirus (KSHV) infection. To determine the factors responsible for the unrestrained proliferation of PEL, we have studied the growth factor requirements of
the PEL-derived BCBL-1 and BC-1 cell lines. Both cell lines were found
to be autocrine growth factor dependent and to release human
interleukin-6 (IL-6), viral IL-6 (vIL-6), and human IL-10 in the
culture supernatant. To establish whether these cytokines contribute to
autocrine growth, neutralizing antibodies against human IL-6, vIL-6,
human IL-10, and soluble IL-10 receptor were used. These experiments
showed that human IL-10 and, to a lesser degree, vIL-6 serve as
autocrine growth factors for BCBL-1 and BC-1 cells. Thus, human IL-10
and vIL-6 are growth factors released and used by PEL cells for
autonomous proliferation and may be critical to the development and
progression of PEL.
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