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Blood, Vol. 94 No. 9 (November 1), 1999:
pp. 3108-3113
Frequent Expression of the B-Cell-Specific Activator Protein in
Reed-Sternberg Cells of Classical Hodgkin's Disease Provides Further
Evidence for Its B-Cell Origin
Hans-Dieter Foss,
Regina Reusch,
Gudrun Demel,
Georg Lenz,
Ioannis Anagnostopoulos,
Michael Hummel, and
Harald Stein
From Konsultations-und Referenzzentrum für Lymphknoten und
Hämatopathologie, the Institute of Pathology, Klinikum Benjamin
Franklin, Free University of Berlin, Berlin, Germany.
The neoplastic cells of classical Hodgkin's disease (cHD), ie,
Hodgkin and Reed-Sternberg cells (HRS cells), contain clonally rearranged Ig genes, but are dissimilar to normal B cells in that they
mostly do not display B-cell antigens such as CD20 or CD19. The
transcription factor B-cell-specific activator protein (BSAP) influences numerous B-cell functions such as B-cell antigen expression, Ig expression, and class switch. We analyzed the expression of BSAP in
cHD and control tissues by isotopic in situ hybridization and
immunohistochemistry to determine whether BSAP is expressed in HRS
cells and, if so, whether it may be involved in the genesis of the
abnormal phenotype of these cells. Both in normal lymphoid tissue and
non-Hodgkin lymphomas, BSAP transcripts and protein were almost
exclusively found in B cells and B-cell lymphomas (40 cases), but were
absent from the tumor cells of T-cell neoplasms (41 cases), including
19 cases of anaplastic large cell lymphoma of T- and null-cell type.
Among cHD, variable numbers of HRS cells exhibited BSAP transcripts (22 of 25 cases) and protein (28 of 31 cases). Our findings show that BSAP
is sufficiently specific to serve as B-cell marker. BSAP expression in
HRS cells provides further strong evidence for a frequent B-cell origin
of cHD and helps distinguish this disease from anaplastic large cell
lymphoma of T- and null-cell type. Because BSAP is much more frequently expressed in HRS cells than the conventional B-cell antigens, the
abnormal immunophenotype of HRS cells with frequent absence of B-cell
antigens does not appear to be due to absent BSAP expression.
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