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Blood, Vol. 95 No. 1 (January 1), 2000:
pp. 128-137
Distinct signals control the hematopoiesis of lymphoid-related
dendritic cells
Anne Galy,
Indu Christopherson,
Guido Ferlazzo,
Guo Liu,
Hergen Spits, and
Katia Georgopoulos
From the Barbara Ann Karmanos Cancer Institute, Wayne State
University, Detroit, MI; Netherlands Cancer Institute, Amsterdam, The
Netherlands; Cutaneous Biology Research Center, Harvard Medical School,
Massachusetts General Hospital, Charlestown, MA.
The molecular and cellular requirements for the development of
different populations of human dendritic cells (DC) were studied. Conditions were defined that support DC production from lymphoid progenitors but that fail to induce DC formation from peripheral monocytes. The production of these lymphoid-related DC was severely blocked when hematopoietic progenitors overexpressed Ik7, a mutant dominant-negative Ikaros protein. In contrast, Ik7 did not block the
formation of DC in conditions supporting the development of monocyte-derived DC. Furthermore, Ik7 did not block the formation of
monocyte/macrophages and enhanced granulopoiesis. One of the molecular
mechanisms mediated by Ik7 appears to be down-regulation of the
flt3-receptor mRNA. Thus, distinct signals control the formation of DC
demonstrating that some aspects of DC diversity are determined in part
by distinct molecular cues at the hematopoietic level. (Blood.
2000;95:128-137)
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