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Blood, Vol. 95 No. 1 (January 1), 2000:
pp. 221-230
A splice variant of human ephrin-A4 encodes a soluble molecule
that is secreted by activated human B lymphocytes
Hans-Christian Aasheim,
Else Munthe,
Steinar Funderud,
Erlend B. Smeland,
Klaus Beiske, and
Ton Logtenberg
From the Departments of Immunology and Pathology, Institute for
Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, and the
Department of Immunology, University Hospital Utrecht, Utrecht, The
Netherlands.
Ephrin-A4 is a ligand for the erythropoietin-producing
hepatocellular (Eph) receptor family of tyrosine kinases. We have
identified a secreted form of ephrin-A4, denoted ephrin-A4 (s), which
is encoded by an alternatively spliced mRNA and is produced by in vivo
activated B cells in tonsils. Blood B cells secrete ephrin-A4 (s) upon
stimulation via the B-cell antigen receptor. A subpopulation of tonsil
cells in the crypts with a dendritic cell phenotype was shown to
express EphA2, an Eph receptor tyrosine kinase that was found to be
capable of binding an ephrin-A4 immunoglobulin chimeric protein. We
conclude that ephrin-A4 (s) may play a role in the interaction between
activated B lymphocytes and dendritic cells in human tonsils. (Blood.
2000;95:221-230)
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