|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 1 (January 1), 2000:
pp. 7-11
PLENARY PAPER
Impact on survival of high-dose therapy with autologous stem cell
support in patients younger than 60 years with newly diagnosed
multiple myeloma: a population-based study
Stig Lenhoff,
Martin Hjorth,
Erik Holmberg,
Ingemar Turesson,
Jan Westin,
Johan Lanng Nielsen,
Finn Wislöff,
Lorentz Brinch,
Kristina Carlson,
Margaretha Carlsson,
Inger-Marie Dahl,
Peter Gimsing,
Erik Hippe,
Hans Johnsen,
Jon Lamvik,
Eva Löfvenberg,
Ingerid Nesthus, and
Stig Rödjer for the Nordic Myeloma Study Group
From the Departments of Hematology, Lund University Hospital,
Sweden; Lidköping Hospital, Sweden; Sahlgrenska University
Hospital, Göteborg, Sweden; Malmö University Hospital,
Sweden; Århus University Hospital, Denmark; Ullevål Hospital,
Oslo, Norway; Rikshospitalet, Oslo, Norway; Akademiska Hospital,
Uppsala, Sweden; Linköping University Hospital, Sweden;
Tromsö University Hospital, Norway; Rigshospitalet,
Köbenhavn, Denmark; Köbenhavn University Hospital, Herlev,
Denmark; Trondheim University Hospital, Norway; Norrland University
Hospital, Umeå, Sweden; and Haukeland Hospital, Bergen, Norway.
High-dose therapy has become a common treatment for myeloma. The
objectives of this study were to estimate in a prospective, population-based setting the impact on survival of high-dose therapy in
newly diagnosed, symptomatic patients less than 60 years old and to
compare the results with those of conventionally treated historic
controls. The prospective population comprised 348 patients. Of these,
274 were treated according to a specified intensive-therapy protocol
(Nordic Myeloma Study Group [NMSG] #5/94) and constituted the
intensive-therapy group. The historic population consisted of 313 patients identified from 5 previous population-based Nordic studies. Of
these, 274 fulfilled the eligibility criteria for high-dose therapy
stated in NMSG #5/94 and constituted the control group. The expected
numbers of patients in the prospective population and the historic
population were 450 and 410, respectively, estimated from previously
established data on the incidence in this population and the population
base for each study. Survival was prolonged in the intensive-therapy
group compared with the control group (risk ratio for the control group
1.62; 95% confidence interval 1.22-2.15; P = .001). These
groups represented more than 60% of the expected number of patients.
When survival for all the registered patients in the 2 populations was
compared, representing more than 75% of the expected number of
patients, the advantage for the prospective population persisted (risk
ratio for the historic population 1.46; 95% confidence interval
1.14-1.86; P = .002). These results indicate that the
introduction of high-dose therapy for newly diagnosed myeloma has
resulted in prolonged survival for the total patient population aged
less than 60 years. (Blood. 2000; 95:7-11)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. J. Vangsted, T. W. Klausen, P. Gimsing, N. F. Andersen, N. Abildgaard, H. Gregersen, and U. Vogel
A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support
Haematologica,
September 1, 2009;
94(9):
1274 - 1281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-S. Eom, C.-K. Min, B.-S. Cho, S. Lee, J.-W. Lee, W.-S. Min, C.-C. Kim, M. Kim, and Y. Kim
Retrospective Comparison of Bortezomib-containing Regimens with Vincristine-Doxorubicin-Dexamethasone (VAD) as Induction Treatment Prior to Autologous Stem Cell Transplantation for Multiple Myeloma
Jpn. J. Clin. Oncol.,
July 1, 2009;
39(7):
449 - 455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lunghi, N. Giuliani, L. Mazzera, G. Lombardi, M. Ricca, A. Corradi, A. M. Cantoni, L. Salvatore, R. Riccioni, A. Costanzo, et al.
Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways
Blood,
September 15, 2008;
112(6):
2450 - 2462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Bensinger
Stem-Cell Transplantation for Multiple Myeloma in the Era of Novel Drugs
J. Clin. Oncol.,
January 20, 2008;
26(3):
480 - 492.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Sonneveld, B. van der Holt, C. M. Segeren, E. Vellenga, A. J. Croockewit, G. E.G. Verhoef, J. J. Cornelissen, M. R. Schaafsma, M. H.J. van Oers, P. W. Wijermans, et al.
Intermediate-dose melphalan compared with myeloablative treatment in multiple myeloma: long-term follow-up of the Dutch Cooperative Group HOVON 24 trial
Haematologica,
July 1, 2007;
92(7):
928 - 935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Y. Kristinsson, O. Landgren, P. W. Dickman, A. R. Derolf, and M. Bjorkholm
Patterns of Survival in Multiple Myeloma: A Population-Based Study of Patients Diagnosed in Sweden From 1973 to 2003
J. Clin. Oncol.,
May 20, 2007;
25(15):
1993 - 1999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dispenzieri, S. V. Rajkumar, M. A. Gertz, M. Q. Lacy, R. A. Kyle, P. R. Greipp, T. E. Witzig, J. A. Lust, S. J. Russell, S. R. Hayman, et al.
Treatment of Newly Diagnosed Multiple Myeloma Based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): Consensus Statement
Mayo Clin. Proc.,
March 1, 2007;
82(3):
323 - 341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hideshima, L. Catley, H. Yasui, K. Ishitsuka, N. Raje, C. Mitsiades, K. Podar, N. C. Munshi, D. Chauhan, P. G. Richardson, et al.
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
Blood,
May 15, 2006;
107(10):
4053 - 4062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cavo, E. Zamagni, P. Tosi, P. Tacchetti, C. Cellini, D. Cangini, A. de Vivo, N. Testoni, C. Nicci, C. Terragna, et al.
Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
Blood,
July 1, 2005;
106(1):
35 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hamasaki, T. Hideshima, P. Tassone, P. Neri, K. Ishitsuka, H. Yasui, N. Shiraishi, N. Raje, S. Kumar, D. H. Picker, et al.
Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo
Blood,
June 1, 2005;
105(11):
4470 - 4476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. van Rhee, S. M. Szmania, F. Zhan, S. K. Gupta, M. Pomtree, P. Lin, R. B. Batchu, A. Moreno, G. Spagnoli, J. Shaughnessy, et al.
NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses
Blood,
May 15, 2005;
105(10):
3939 - 3944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Morris, S. Iacobelli, R. Brand, B. Bjorkstrand, M. Drake, D. Niederwieser, and G. Gahrton
Benefit and Timing of Second Transplantations in Multiple Myeloma: Clinical Findings and Methodological Limitations in a European Group for Blood and Marrow Transplantation Registry Study
J. Clin. Oncol.,
May 1, 2004;
22(9):
1674 - 1681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Barlogie, J. Shaughnessy, G. Tricot, J. Jacobson, M. Zangari, E. Anaissie, R. Walker, and J. Crowley
Treatment of multiple myeloma
Blood,
January 1, 2004;
103(1):
20 - 32.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Stadtmauer
Multiple Myeloma, 2004 -- One or Two Transplants?
N. Engl. J. Med.,
December 25, 2003;
349(26):
2551 - 2553.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hideshima, D. Chauhan, T. Hayashi, K. Podar, M. Akiyama, C. Mitsiades, N. MItsiades, B. Gong, L. Bonham, P. de Vries, et al.
Antitumor Activity of Lysophosphatidic Acid Acyltransferase-{beta} Inhibitors, a Novel Class of Agents, in Multiple Myeloma
Cancer Res.,
December 1, 2003;
63(23):
8428 - 8436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kaufmann, J. Ackermann, H. Greinix, T. Nosslinger, H. Gisslinger, A. Keck, H. Ludwig, N. Worel, P. Kalhs, C. Zielinski, et al.
Beneficial effect of high-dose chemotherapy in multiple myeloma patients with unfavorable prognostic features
Ann. Onc.,
November 1, 2003;
14(11):
1667 - 1672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Child, G. J. Morgan, F. E. Davies, R. G. Owen, S. E. Bell, K. Hawkins, J. Brown, M. T. Drayson, P. J. Selby, and the Medical Research Council Adult Leukaemia Worki
High-Dose Chemotherapy with Hematopoietic Stem-Cell Rescue for Multiple Myeloma
N. Engl. J. Med.,
May 8, 2003;
348(19):
1875 - 1883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Lokhorst, C. M. Segeren, L. F. Verdonck, B. van der Holt, R. Raymakers, M. H.J. van Oers, R. M.Y. Barge, H. C. Schouten, P. H.M. Westveer, M. M.C. Steijaert, et al.
Partially T-Cell-Depleted Allogeneic Stem-Cell Transplantation for First-Line Treatment of Multiple Myeloma: A Prospective Evaluation of Patients Treated in the Phase III Study HOVON 24 MM
J. Clin. Oncol.,
May 1, 2003;
21(9):
1728 - 1733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Segeren, P. Sonneveld, B. van der Holt, E. Vellenga, A. J. Croockewit, G. E. G. Verhoef, J. J. Cornelissen, M. R. Schaafsma, M. H. J. van Oers, P. W. Wijermans, et al.
Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study
Blood,
March 15, 2003;
101(6):
2144 - 2151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Standal, M. Borset, S. Lenhoff, F. Wisloff, B. Stordal, A. Sundan, A. Waage, and C. Seidel
Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor
Blood,
December 1, 2002;
100(12):
3925 - 3929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Robertson, D. Pelloso, R. Abonour, R. A. Hromas, R. P. Nelson Jr., L. Wood, and K. Cornetta
Interleukin 12 Immunotherapy after Autologous Stem Cell Transplantation for Hematological Malignancies
Clin. Cancer Res.,
November 1, 2002;
8(11):
3383 - 3393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Alexanian, D. Weber, S. Giralt, and K. Delasalle
Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy
Ann. Onc.,
July 1, 2002;
13(7):
1116 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dotti, B. Savoldo, P. Yotnda, D. Rill, and M. K. Brenner
Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40+ and CD40- plasmacytoma cells
Blood,
June 17, 2002;
100(1):
200 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-T. Brenne, T. Baade Ro, A. Waage, A. Sundan, M. Borset, and H. Hjorth-Hansen
Interleukin-21 is a growth and survival factor for human myeloma cells
Blood,
May 15, 2002;
99(10):
3756 - 3762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Imrie, R. Esmail, R. M. Meyer, and and the Members of the Hematology Disease Site Gro
The Role of High-Dose Chemotherapy and Stem-Cell Transplantation in Patients with Multiple Myeloma: A Practice Guideline of the Cancer Care Ontario Practice Guidelines Initiative
Ann Intern Med,
April 16, 2002;
136(8):
619 - 629.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Badros, B. Barlogie, E. Siegel, M. Cottler-Fox, M. Zangari, A. Fassas, C. Morris, E. Anaissie, F. Van Rhee, and G. Tricot
Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning
J. Clin. Oncol.,
March 1, 2002;
20(5):
1295 - 1303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. San Miguel, J. Almeida, G. Mateo, J. Blade, C. Lopez-Berges, D. Caballero, J. Hernandez, M. J. Moro, J. Fernandez-Calvo, J. Diaz-Mediavilla, et al.
Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome
Blood,
March 1, 2002;
99(5):
1853 - 1856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Moreau, T. Facon, M. Attal, C. Hulin, M. Michallet, F. Maloisel, J.-J. Sotto, F. Guilhot, G. Marit, C. Doyen, et al.
Comparison of 200 mg/m2 melphalan and 8 Gy total body irradiation plus 140 mg/m2 melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial
Blood,
February 1, 2002;
99(3):
731 - 735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Dalton, P. L. Bergsagel, W. M. Kuehl, K. C. Anderson, and J. L. Harousseau
Multiple Myeloma
Hematology,
January 1, 2001;
2001(1):
157 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
