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Blood, Vol. 95 No. 10 (May 15), 2000:
pp. 3113-3124
Functionally defined CD164 epitopes are expressed on
CD34+ cells throughout ontogeny but display distinct
distribution patterns in adult hematopoietic and nonhematopoietic
tissues
Suzanne M. Watt,
Lisa H. Butler,
Manuela Tavian,
Hans-Jörg Bühring,
Irene Rappold,
Paul J. Simmons,
Andrew C. W. Zannettino,
David Buck,
Anja Fuchs,
Regis Doyonnas,
James Yi-Hsin Chan,
Jean-Pierre Levesque,
Bruno Peault, and
Ioannis Roxanis
From the MRC Molecular Haematology Unit and from the Neurosciences
Group, Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford, England; INSERM Unite 506, Groupe Hospitalier Paul
Brousse, Villejuif Cedex, France; Medizinische Universitätsklinik
II, University of Tübingen, Tübingen, Germany; Stem Cell
Laboratory, Peter MacCallum Cancer Institute, Melbourne, Australia;
Hanson Centre for Cancer Research, Adelaide, Australia; StemCells Inc,
Sunnyvale, CA; Miltenyi Biotec, Bergisch Gladbach,
Germany.
Three distinct classes of epitopes on human CD164 have been
identified. Two of these, recognized by the monoclonal antibodies 105A5
and 103B2/9E10, are the CD164 class I and class II functionally defined
epitopes, which cooperate to regulate adhesion and proliferation of
CD34+ cell subsets. In this article, we demonstrate that
these 2 CD164 epitopes are expressed on CD34+ cells
throughout ontogeny, in particular on CD34+ cell clusters
associated with the ventral floor of the dorsal aorta in the developing
embryo and on CD34+ hematopoietic precursor cells in
fetal liver, cord blood, and adult bone marrow. While higher
levels of expression of these CD164 epitopes occur on the
more primitive
AC133hiCD34hiCD38lo/ cell
population, they also occur on most cord blood
LinCD34lo/CD38lo/ cells,
which are potential precursors for the
AC133hiCD34hiCD38lo/ subset. In
direct contrast to these common patterns of expression on hematopoietic
precursor cells, notable differences in expression of the CD164
epitopes were observed in postnatal lymphoid and nonhematopoietic
tissues, with the class I and class II CD164 epitopes generally
exhibiting differential and often reciprocal cellular distribution
patterns. This is particularly striking in the colon, where
infiltrating lymphoid cells are CD164 class I-positive but
class II-negative, while epithelia are weakly CD164 class
II-positive. Similarly, in certain lymphoid tissues, high endothelial
venules and basal and subcapsular epithelia are CD164 class
II-positive, while lymphoid cells are CD164 class I-positive. It
therefore seems highly likely that these CD164 class I and II epitopes
will mediate reciprocal homing functions in these tissue types.
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