|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 11 (June 1), 2000:
pp. 3289-3296
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and
VLA-5 on immature human CD34+ cells: role in
transendothelial/stromal migration and engraftment of NOD/SCID mice
Amnon Peled,
Orit Kollet,
Tanya Ponomaryov,
Isabelle Petit,
Suzanna Franitza,
Valentin Grabovsky,
Michal Magid Slav,
Arnon Nagler,
Ofer Lider,
Ronen Alon,
Dov Zipori, and
Tsvee Lapidot
From the Departments of Immunology and Molecular Cell Biology, The
Weizmann Institute of Science, Rehovot, Israel, and the Haddasa
University Hospital, Jerusalem, Israel.
Hematopoietic stem cell homing and engraftment require several
adhesion interactions, which are not fully understood. Engraftment of
nonobese/severe combined immunodeficiency (NOD/SCID) mice by human stem
cells is dependent on the major integrins very late activation
antigen-4 (VLA-4); VLA-5; and to a lesser degree, lymphocyte function
associated antigen-1 (LFA-1). Treatment of human CD34+
cells with antibodies to either VLA-4 or VLA-5 prevented engraftment, and treatment with anti-LFA-1 antibodies significantly reduced the
levels of engraftment. Activation of CD34+ cells, which
bear the chemokine receptor CXCR4, with stromal derived factor 1 (SDF-1) led to firm adhesion and transendothelial migration, which was
dependent on LFA-1/ICAM-1 (intracellular adhesion molecule-1) and
VLA-4/VCAM-1 (vascular adhesion molecule-1). Furthermore,
SDF-1-induced polarization and extravasation of
CD34+/CXCR4+ cells through the
extracellular matrix underlining the endothelium was dependent on
both VLA-4 and VLA-5. Our results demonstrate that repopulating
human stem cells functionally express LFA-1, VLA-4, and VLA-5.
Furthermore, this study implies a novel approach to further advance
clinical transplantation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. T. Ngo, X. Leleu, J. Lee, X. Jia, M. Melhem, J. Runnels, A.-S. Moreau, N. Burwick, A. K. Azab, A. Roccaro, et al.
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia
Blood,
July 1, 2008;
112(1):
150 - 158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Zemani, J.-S. Silvestre, F. Fauvel-Lafeve, A. Bruel, J. Vilar, I. Bieche, I. Laurendeau, I. Galy-Fauroux, A. M. Fischer, and C. Boisson-Vidal
Ex Vivo Priming of Endothelial Progenitor Cells With SDF-1 Before Transplantation Could Increase Their Proangiogenic Potential
Arterioscler. Thromb. Vasc. Biol.,
April 1, 2008;
28(4):
644 - 650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Mahlknecht and C. Schonbein
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells
Haematologica,
March 1, 2008;
93(3):
443 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Mazzinghi, E. Ronconi, E. Lazzeri, C. Sagrinati, L. Ballerini, M. L. Angelotti, E. Parente, R. Mancina, G. S. Netti, F. Becherucci, et al.
Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells
J. Exp. Med.,
February 18, 2008;
205(2):
479 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-P. Chen, M.-Y. Lee, J.-P. Huang, J. D. Aplin, Y.-H. Wu, C.-S. Hu, P.-C. Chen, H. Li, S.-M. Hwang, S.-H. Liu, et al.
Trafficking of Multipotent Mesenchymal Stromal Cells from Maternal Circulation Through the Placenta Involves Vascular Endothelial Growth Factor Receptor-1 and Integrins
Stem Cells,
February 1, 2008;
26(2):
550 - 561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yamamura, K. Ohishi, M. Masuya, E. Miyata, Y. Sugimoto, S. Nakamura, A. Fujieda, H. Araki, and N. Katayama
Ex Vivo Culture of Human Cord Blood Hematopoietic Stem/Progenitor Cells Adversely Influences Their Distribution to Other Bone Marrow Compartments After Intra-Bone Marrow Transplantation
Stem Cells,
February 1, 2008;
26(2):
543 - 549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sugano, M. Takeuchi, A. Hirata, H. Matsushita, T. Kitamura, M. Tanaka, and A. Miyajima
Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells
Blood,
February 1, 2008;
111(3):
1167 - 1172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Stellos, H. Langer, K. Daub, T. Schoenberger, A. Gauss, T. Geisler, B. Bigalke, I. Mueller, M. Schumm, I. Schaefer, et al.
Platelet-Derived Stromal Cell Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells
Circulation,
January 15, 2008;
117(2):
206 - 215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Sharp, M. Huang, J. Glawe, D. R. Patrick, S. Pardue, S. C. Barlow, and C. G. Kevil
Stromal Cell Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium
Diabetes,
January 1, 2008;
57(1):
102 - 112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bastianutto, A. Mian, J. Symes, J. Mocanu, N. Alajez, G. Sleep, W. Shi, A. Keating, M. Crump, M. Gospodarowicz, et al.
Local Radiotherapy Induces Homing of Hematopoietic Stem Cells to the Irradiated Bone Marrow
Cancer Res.,
November 1, 2007;
67(21):
10112 - 10116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Qian, E. Georges-Labouesse, A. Nystrom, A. Domogatskaya, K. Tryggvason, S. E. W. Jacobsen, and M. Ekblom
Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells
Blood,
October 1, 2007;
110(7):
2399 - 2407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Xu, A. Mora, H. Shim, A. Stecenko, K. L. Brigham, and M. Rojas
Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and Fibrosis
Am. J. Respir. Cell Mol. Biol.,
September 1, 2007;
37(3):
291 - 299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Basu, N. T. Ray, S. J. Atkinson, and H. E. Broxmeyer
Protein Phosphatase 2A Plays an Important Role in Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12-Mediated Migration and Adhesion of CD34+ Cells
J. Immunol.,
September 1, 2007;
179(5):
3075 - 3085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fukuda, H. Bian, A. G. King, and L. M. Pelus
The chemokine GRO{beta} mobilizes early hematopoietic stem cells characterized by enhanced homing and engraftment
Blood,
August 1, 2007;
110(3):
860 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Dao, M. H. Creer, J. A. Nolta, and C. M. Verfaillie
Biology of umbilical cord blood progenitors in bone marrow niches
Blood,
July 1, 2007;
110(1):
74 - 81.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Forde, B. J. Tye, S. E. Newey, M. Roubelakis, J. Smythe, C. P. McGuckin, R. Pettengell, and S. M. Watt
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells
Blood,
March 1, 2007;
109(5):
1825 - 1833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Rossi, R. Manfredini, F. Bertolini, D. Ferrari, M. Fogli, R. Zini, S. Salati, V. Salvestrini, S. Gulinelli, E. Adinolfi, et al.
The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration
Blood,
January 15, 2007;
109(2):
533 - 542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Pandit, L. Sikora, G. Muralidhar, S. P. Rao, and P. Sriramarao
Sustained Exposure to Nicotine Leads to Extramedullary Hematopoiesis in the Spleen
Stem Cells,
November 1, 2006;
24(11):
2373 - 2381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Rossi, M. Espeli, C. Schiff, and L. Gauthier
Clustering of Pre-B Cell Integrins Induces Galectin-1-Dependent Pre-B Cell Receptor Relocalization and Activation
J. Immunol.,
July 15, 2006;
177(2):
796 - 803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Desponts, A. L. Hazen, K. H. T. Paraiso, and W. G. Kerr
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation
Blood,
June 1, 2006;
107(11):
4338 - 4345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Blindt, F. Vogt, I. Astafieva, C. Fach, M. Hristov, N. Krott, B. Seitz, A. Kapurniotu, C. Kwok, M. Dewor, et al.
A Novel Drug-Eluting Stent Coated With an Integrin-Binding Cyclic Arg-Gly-Asp Peptide Inhibits Neointimal Hyperplasia by Recruiting Endothelial Progenitor Cells
J. Am. Coll. Cardiol.,
May 2, 2006;
47(9):
1786 - 1795.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Qian, K. Tryggvason, S. E. Jacobsen, and M. Ekblom
Contribution of {alpha}6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with {alpha}4 integrins
Blood,
May 1, 2006;
107(9):
3503 - 3510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Fushimi, T. P. O'Connor, and R. G. Crystal
Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth.
Cancer Res.,
April 1, 2006;
66(7):
3513 - 3522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Jaatinen, H. Hemmoranta, S. Hautaniemi, J. Niemi, D. Nicorici, J. Laine, O. Yli-Harja, and J. Partanen
Global Gene Expression Profile of Human Cord Blood-Derived CD133+ Cells
Stem Cells,
March 1, 2006;
24(3):
631 - 641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Pearce, D. Taussig, K. Zibara, L.-L. Smith, C. M. Ridler, C. Preudhomme, B. D. Young, A. Z. Rohatiner, T. A. Lister, and D. Bonnet
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
Blood,
February 1, 2006;
107(3):
1166 - 1173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Qin, M. Ii, M. Silver, A. Wecker, E. Bord, H. Ma, M. Gavin, D. A. Goukassian, Y.-s. Yoon, T. Papayannopoulou, et al.
Functional disruption of {alpha}4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization
J. Exp. Med.,
January 23, 2006;
203(1):
153 - 163.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Bonig, G. V. Priestley, and T. Papayannopoulou
Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines
Blood,
January 1, 2006;
107(1):
79 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Dimarakis, N. A. Habib, and M. Y.A. Gordon
Adult bone marrow-derived stem cells and the injured heart: just the beginning?
Eur. J. Cardiothorac. Surg.,
November 1, 2005;
28(5):
665 - 676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-G. Kopp, S. T. Avecilla, A. T. Hooper, and S. Rafii
The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Physiology,
October 1, 2005;
20(5):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Lapidot, A. Dar, and O. Kollet
How do stem cells find their way home?
Blood,
September 15, 2005;
106(6):
1901 - 1910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Dalakas, P. N. Newsome, D. J. Harrison, and J. N. Plevris
Hematopoietic stem cell trafficking in liver injury
FASEB J,
August 1, 2005;
19(10):
1225 - 1231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kucia, R. Reca, K. Miekus, J. Wanzeck, W. Wojakowski, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1-CXCR4 Axis
Stem Cells,
August 1, 2005;
23(7):
879 - 894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Basu and H. E. Broxmeyer
Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12
Blood,
July 15, 2005;
106(2):
485 - 493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Xu, E. Bruno, J. Chao, S. Huang, G. Finazzi, S. M. Fruchtman, U. Popat, J. T. Prchal, G. Barosi, R. Hoffman, et al.
Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases
Blood,
June 1, 2005;
105(11):
4508 - 4515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kortesidis, A. Zannettino, S. Isenmann, S. Shi, T. Lapidot, and S. Gronthos
Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
Blood,
May 15, 2005;
105(10):
3793 - 3801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bendall, R. Baraz, J. Juarez, W. Shen, and K. F. Bradstock
Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1{alpha} in Acute Lymphoblastic Leukemia
Cancer Res.,
April 15, 2005;
65(8):
3290 - 3298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Manfredini, R. Zini, S. Salati, M. Siena, E. Tenedini, E. Tagliafico, M. Montanari, T. Zanocco-Marani, C. Gemelli, T. Vignudelli, et al.
The Kinetic Status of Hematopoietic Stem Cell Subpopulations Underlies a Differential Expression of Genes Involved in Self-Renewal, Commitment, and Engraftment
Stem Cells,
April 1, 2005;
23(4):
496 - 506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jansen, F.-C. Yang, J. A. Cancelas, J. R. Bailey, and D. A. Williams
Rac2-Deficient Hematopoietic Stem Cells Show Defective Interaction with the Hematopoietic Microenvironment and Long-Term Engraftment Failure
Stem Cells,
March 1, 2005;
23(3):
335 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hidalgo and P. S. Frenette
Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow
Blood,
January 15, 2005;
105(2):
567 - 575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
