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Blood, Vol. 95 No. 11 (June 1), 2000:
pp. 3628-3630
BRIEF REPORT
Expression of CD94/NKG2A and killer immunoglobulin-like receptors
in NK cells and a subset of extranodal cytotoxic T-cell lymphomas
Wolfgang Haedicke,
Faith C. S. Ho,
Andreas Chott,
Lorenzo Moretta,
Thomas Rüdiger,
German Ott, and
Hans Konrad Müller-Hermelink
From the Institute of Pathology, University of Würzburg,
Würzburg, Germany; the Department of Pathology and
Immunology, Monash University, Melbourne, Australia; the
Institute of Clinical Pathology, University of Vienna,
Austria; the Dipartimento di Medicina Sperimentale, University of
Genoa, and Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Thirty-two natural killer (NK) and cytotoxic T-cell lymphomas and 14 noncytotoxic nodal T-cell lymphoma controls were immunostained with the
use of monoclonal antibodies reactive against NK-cell receptor (NKR)
molecules (CD94, NKG2A, p58.2, p58.1, p140, p70, p50.3). All NK-cell
lymphomas (4 nasal/oral and 1 intestinal) expressed at least 1 NKR, the
CD94/NKG2A complex. Two were positive for 1 or more killer
immunoglobulin-like receptors. Of 15 extranodal cytotoxic T-cell
lymphomas, 3 expressed CD94, including 2 intestinal and 1 hepatosplenic
  T-cell lymphomas. In contrast, none of the nodal lymphomas were
positive. Detection of NKRs may provide a useful tool to confirm the
diagnosis of NK-cell lymphomas and to delineate a subgroup of cytotoxic
T-cell lymphomas. Expression of NKRs only in extranodal cytotoxic
T-cell lymphomas might reflect differences in the homing capabilities
of cytotoxic T cells expressing NKRs in normal individuals and might be
influenced in part by localized chronic immune reactions.
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