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Blood, Vol. 95 No. 2 (January 15), 2000:
pp. 715-718
BRIEF REPORT
C-C chemokine profile of cord blood mononuclear cells:
selective defect in RANTES production
Deepa Hariharan,
Wenzhe Ho,
Joann Cutilli,
Donald E. Campbell, and
Steven D. Douglas
From the Divisions of Neonatology and Immunologic and Infectious
Diseases and the Clinical Immunology Laboratories, The Children's
Hospital of Philadelphia, University of Pennsylvania School of
Medicine, Philadelphia, PA.
Three C-C chemokines inhibit human immunodeficiency virus (HIV)
entry into macrophages: macrophage inflammatory protein-1 (MIP-1), MIP-1 , and regulated-upon activation, normal T-cell expressed and secreted (RANTES). We studied the ability of placental cord blood mononuclear cells (CBMC) to secrete these C-C chemokines in
comparison to adult blood mononuclear cells (ABMC). CBMC had diminished
ability to secrete RANTES, as determined by enzyme-linked immunosorbent
assay. Secretion of MIP-1 and MIP-1 were similar in CBMC and
ABMC. Whereas MIP-1 and MIP-1 secretion were comparable in
monocytes and lymphocytes, RANTES was secreted primarily by lymphocytes. Flow cytometric analysis of RANTES expression showed diminished intracellular RANTES expression in cord blood lymphocytes (CBL) compared to adult (peripheral) blood lymphocytes (ABL). A subset
analysis of RANTES-producing CBL and ABL demonstrated that RANTES was
produced predominantly by CD8+/CD45RO+ cells. CBL had a reduced
proportion of CD8+/CD45RO+ cells compared with ABL, which may
account for the diminished RANTES secretion by CBMC. These results may
be relevant to the pathogenesis of perinatal HIV infection.
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