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Blood, Vol. 95 No. 2 (January 15), 2000:
pp. 719-720
BRIEF REPORT
Strong FANCA/FANCG but weak FANCA/FANCC interaction in the
yeast 2-hybrid system
Tanja Reuter,
Sabine Herterich,
Oliver Bernhard,
Holger Hoehn, and
Hans J. Gross
From the Departments of Biochemistry and Human Genetics, University
of Würzburg, Würzburg, Germany.
Three of at least 8 Fanconi anemia (FA) genes have been cloned
(FANCA, FANCC, FANCG), but their functions remain unknown. Using the
yeast 2-hybrid system and full-length cDNA, the authors found a strong
interaction between FANCA and FANCG proteins. They also obtained
evidence for a weak interaction between FANCA and FANCC. Neither FANCA
nor FANCC was found to interact with itself. These results support the
notion of a functional association between the FA gene products.
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