|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 3 (February 1), 2000:
pp. 756-768
Chemokine SDF-1 enhances circulating CD34+ cell
proliferation in synergy with cytokines: possible role in progenitor
survival
Jean-Jacques Lataillade,
Denis Clay,
Catherine Dupuy,
Sylvain Rigal,
Claude Jasmin,
Philippe Bourin, and
Marie-Caroline Le Bousse-Kerdilès
From the Laboratoire d'Immunologie Cellulaire, Centre de
Transfusion Sanguine des Armées Jean Julliard, Clamart Cedex,
France; Institut National de la Santé et de la Recherche
Médicale, Hôpital Paul Brousse, Villejuif, France;
Hôpital d'Instruction des Armées Percy, Clamart Cedex,
France.
The chemokine stromal cell-derived factor-1 (SDF-1), and its
receptor, CXCR-4, have been implicated in the homing and mobilization of human CD34+ cells. We show here that SDF-1 may also be
involved in hematopoiesis, promoting the proliferation of human
CD34+ cells purified from normal adult peripheral blood
(PB). CXCR-4 was expressed on PB CD34+ cells. The amount
of CXCR-4 on PB CD34+ cells was 10 times higher when
CD34+ cells were purified following overnight incubation.
CXCR-4 overexpression was correlated with a primitive PB
CD34+ cell subset defined by a
CD34high CD38lowCD71lowc-KitlowThy-1+
antigenic profile. The functional significance of CXCR-4 expression was
ascertained by assessing the promoting effect of SDF-1 on cell
cycle, proliferation, and colony formation. SDF-1 alone increased the
percentage of CD34+ cells in the S+G2/M
phases and sustained their survival. In synergy with cytokines, SDF-1
increased PB CD34+ and
CD34highCD38low cell expansion and colony
formation. SDF-1 also stimulated the growth of colonies derived from
primitive progenitors released from quiescence by anti-TGF-
treatment. Thus, our results shed new light on the potential role of
this chemokine in the stem cell engraftment process, which involves
migration, adhesion, and proliferation. Furthermore, both
adhesion-induced CXCR-4 overexpression and SDF-1 stimulating activity
may be of clinical relevance for improving cell therapy settings in
stem cell transplantation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Wang, Y. Shiozawa, J. Wang, Y. Wang, Y. Jung, K. J. Pienta, R. Mehra, R. Loberg, and R. S. Taichman
The Role of CXCR7/RDC1 as a Chemokine Receptor for CXCL12/SDF-1 in Prostate Cancer
J. Biol. Chem.,
February 15, 2008;
283(7):
4283 - 4294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Stellos, H. Langer, K. Daub, T. Schoenberger, A. Gauss, T. Geisler, B. Bigalke, I. Mueller, M. Schumm, I. Schaefer, et al.
Platelet-Derived Stromal Cell Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells
Circulation,
January 15, 2008;
117(2):
206 - 215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Rawls, A. D. Gregory, J. R. Woloszynek, F. Liu, and D. C. Link
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential
Blood,
October 1, 2007;
110(7):
2414 - 2422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Juarez, R. Baraz, S. Gaundar, K. Bradstock, and L. Bendall
Interaction of interleukin-7 and interleukin-3 with the CXCL12-induced proliferation of B-cell progenitor acute lymphoblastic leukemia
Haematologica,
April 1, 2007;
92(4):
450 - 459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakayama, N. Mutsuga, and G. Tosato
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc
Blood,
February 15, 2007;
109(4):
1363 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakayama, N. Mutsuga, and G. Tosato
Effect of Fibroblast Growth Factor 2 on Stromal Cell-Derived Factor 1 Production by Bone Marrow Stromal Cells and Hematopoiesis
J Natl Cancer Inst,
February 7, 2007;
99(3):
223 - 235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Sainz and M. Sata
CXCR4, a Key Modulator of Vascular Progenitor Cells
Arterioscler. Thromb. Vasc. Biol.,
February 1, 2007;
27(2):
263 - 265.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, R. G. Reca, P. Atmaca-Sonmez, M. Z. Ratajczak, S. T. Ildstad, H. J. Kaplan, and V. Enzmann
Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells.
Invest. Ophthalmol. Vis. Sci.,
April 1, 2006;
47(4):
1646 - 1652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Honczarenko, Y. Le, M. Swierkowski, I. Ghiran, A. M. Glodek, and L. E. Silberstein
Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional Chemokine Receptors
Stem Cells,
April 1, 2006;
24(4):
1030 - 1041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Muguruma, T. Yahata, H. Miyatake, T. Sato, T. Uno, J. Itoh, S. Kato, M. Ito, T. Hotta, and K. Ando
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
Blood,
March 1, 2006;
107(5):
1878 - 1887.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Narducci, E. Scala, A. Bresin, E. Caprini, M. C. Picchio, D. Remotti, G. Ragone, F. Nasorri, M. Frontani, D. Arcelli, et al.
Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV
Blood,
February 1, 2006;
107(3):
1108 - 1115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Li, C. K. Y. Chuen, S. M. Lee, P. Law, T. F. Fok, P. C. Ng, C. K. Li, D. Wong, A. Merzouk, H. Salari, et al.
Small Peptide Analogue of SDF-1{alpha} Supports Survival of Cord Blood CD34+ Cells in Synergy with Other Cytokines and Enhances Their Ex Vivo Expansion and Engraftment into Nonobese Diabetic/Severe Combined Immunodeficient Mice
Stem Cells,
January 1, 2006;
24(1):
55 - 64.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Woerner, N. M. Warrington, A. L. Kung, A. Perry, and J. B. Rubin
Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies
Cancer Res.,
December 15, 2005;
65(24):
11392 - 11399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia
A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis
J. Cell Sci.,
October 1, 2005;
118(19):
4343 - 4352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. K. Haider and M. Ashraf
Bone marrow stem cell transplantation for cardiac repair
Am J Physiol Heart Circ Physiol,
June 1, 2005;
288(6):
H2557 - H2567.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. Lataillade, D. Clay, C. David, L. Boutin, B. Guerton, M. Drouet, F. Herodin, and M.-C. Le Bousse-Kerdiles
Phenotypic and functional characteristics of CD34+ cells are related to their anatomical environment: is their versatility a prerequisite for their bio-availability?
J. Leukoc. Biol.,
May 1, 2005;
77(5):
634 - 643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bendall, R. Baraz, J. Juarez, W. Shen, and K. F. Bradstock
Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1{alpha} in Acute Lymphoblastic Leukemia
Cancer Res.,
April 15, 2005;
65(8):
3290 - 3298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zernecke, A. Schober, I. Bot, P. von Hundelshausen, E. A. Liehn, B. Mopps, M. Mericskay, P. Gierschik, E. A. Biessen, and C. Weber
SDF-1{alpha}/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells
Circ. Res.,
April 15, 2005;
96(7):
784 - 791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Byk, J. Kahn, O. Kollet, I. Petit, S. Samira, S. Shivtiel, H. Ben-Hur, A. Peled, W. Piacibello, and T. Lapidot
Cycling G1 CD34+/CD38+ Cells Potentiate the Motility and Engraftment of Quiescent G0 CD34+/CD38-/low Severe Combined Immunodeficiency Repopulating Cells
Stem Cells,
April 1, 2005;
23(4):
561 - 574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Sela, R. Hershkoviz, L. Cahalon, O. Lider, and E. Mozes
Down-Regulation of Stromal Cell-Derived Factor-1{alpha}-Induced T Cell Chemotaxis by a Peptide Based on the Complementarity-Determining Region 1 of an Anti-DNA Autoantibody via Up-Regulation of TGF-{beta} Secretion
J. Immunol.,
January 1, 2005;
174(1):
302 - 309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Brenner, N. Whiting-Theobald, T. Kawai, G. F. Linton, A. G. Rudikoff, U. Choi, M. F. Ryser, P. M. Murphy, J. M.G. Sechler, and H. L. Malech
CXCR4-Transgene Expression Significantly Improves Marrow Engraftment of Cultured Hematopoietic Stem Cells
Stem Cells,
December 1, 2004;
22(7):
1128 - 1133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Jaleel, A. C. Tsai, S. Sarkar, P. V. Freedman, and L. P. Rubin
Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival
Mol. Hum. Reprod.,
December 1, 2004;
10(12):
901 - 909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Mavier, N. Martin, D. Couchie, A.-M. Preaux, Y. Laperche, and E. S. Zafrani
Expression of Stromal Cell-Derived Factor-1 and of Its Receptor CXCR4 in Liver Regeneration from Oval Cells in Rat
Am. J. Pathol.,
December 1, 2004;
165(6):
1969 - 1977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Qiuping, X. Jei, J. Youxin, J. Wei, L. Chun, W. Jin, W. Qun, L. Yan, H. Chunsong, Y. Mingzhen, et al.
CC Chemokine Ligand 25 Enhances Resistance to Apoptosis in CD4+ T Cells from Patients with T-Cell Lineage Acute and Chronic Lymphocytic Leukemia by Means of Livin Activation
Cancer Res.,
October 15, 2004;
64(20):
7579 - 7587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-C. Shyu, S.-Z. Lin, H.-I Yang, Y.-S. Tzeng, C.-Y. Pang, P.-S. Yen, and H. Li
Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor-Stimulated Stem Cells
Circulation,
September 28, 2004;
110(13):
1847 - 1854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. C. Rombouts, B. Pavic, B. Lowenberg, and R. E. Ploemacher
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
Blood,
July 15, 2004;
104(2):
550 - 557.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kimura, A. M. Boehmler, G. Seitz, S. Kuci, T. Wiesner, V. Brinkmann, L. Kanz, and R. Mohle
The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells
Blood,
June 15, 2004;
103(12):
4478 - 4486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tavor, I. Petit, S. Porozov, A. Avigdor, A. Dar, L. Leider-Trejo, N. Shemtov, V. Deutsch, E. Naparstek, A. Nagler, et al.
CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice
Cancer Res.,
April 15, 2004;
64(8):
2817 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kahn, T. Byk, L. Jansson-Sjostrand, I. Petit, S. Shivtiel, A. Nagler, I. Hardan, V. Deutsch, Z. Gazit, D. Gazit, et al.
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation
Blood,
April 15, 2004;
103(8):
2942 - 2949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Avigdor, P. Goichberg, S. Shivtiel, A. Dar, A. Peled, S. Samira, O. Kollet, R. Hershkoviz, R. Alon, I. Hardan, et al.
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
Blood,
April 15, 2004;
103(8):
2981 - 2989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. C. Liles, H. E. Broxmeyer, E. Rodger, B. Wood, K. Hubel, S. Cooper, G. Hangoc, G. J. Bridger, G. W. Henson, G. Calandra, et al.
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
Blood,
October 15, 2003;
102(8):
2728 - 2730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Broxmeyer, L. Kohli, C. H. Kim, Y. Lee, C. Mantel, S. Cooper, G. Hangoc, M. Shaheen, X. Li, and D. W. Clapp
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G{alpha}i proteins and enhances engraftment of competitive, repopulating stem cells
J. Leukoc. Biol.,
May 1, 2003;
73(5):
630 - 638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ara, M. Itoi, K. Kawabata, T. Egawa, K. Tokoyoda, T. Sugiyama, N. Fujii, T. Amagai, and T. Nagasawa
A Role of CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1/Pre-B Cell Growth Stimulating Factor and Its Receptor CXCR4 in Fetal and Adult T Cell Development in Vivo
J. Immunol.,
May 1, 2003;
170(9):
4649 - 4655.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yahata, K. Ando, T. Sato, H. Miyatake, Y. Nakamura, Y. Muguruma, S. Kato, and T. Hotta
A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow
Blood,
April 15, 2003;
101(8):
2905 - 2913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Herodin, P. Bourin, J.-F. Mayol, J.-J. Lataillade, and M. Drouet
Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival
Blood,
April 1, 2003;
101(7):
2609 - 2616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-i. Yamaguchi, K. F. Kusano, O. Masuo, A. Kawamoto, M. Silver, S. Murasawa, M. Bosch-Marce, H. Masuda, D. W. Losordo, J. M. Isner, et al.
Stromal Cell-Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization
Circulation,
March 11, 2003;
107(9):
1322 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-C. Gu, J. Kortesmaa, K. Tryggvason, J. Persson, P. Ekblom, S.-E. Jacobsen, and M. Ekblom
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
Blood,
February 1, 2003;
101(3):
877 - 885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Broxmeyer, S. Cooper, L. Kohli, G. Hangoc, Y. Lee, C. Mantel, D. W. Clapp, and C. H. Kim
Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo
J. Immunol.,
January 1, 2003;
170(1):
421 - 429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Cottler-Fox, T. Lapidot, I. Petit, O. Kollet, J. F. DiPersio, D. Link, and S. Devine
Stem Cell Mobilization
Hematology,
January 1, 2003;
2003(1):
419 - 437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Murakami, W. Maki, A. R. Cardones, H. Fang, A. Tun Kyi, F. O. Nestle, and S. T. Hwang
Expression of CXC Chemokine Receptor-4 Enhances the Pulmonary Metastatic Potential of Murine B16 Melanoma Cells
Cancer Res.,
December 1, 2002;
62(24):
7328 - 7334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kijima, G. Maulik, P. C. Ma, E. V. Tibaldi, R. E. Turner, B. Rollins, M. Sattler, B. E. Johnson, and R. Salgia
Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells
Cancer Res.,
November 1, 2002;
62(21):
6304 - 6311.
[Abstract]
[Full Text]
[PDF]
|
|
< |
