|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 4 (February 15), 2000:
pp. 1158-1166
The CXC-chemokine platelet factor 4 promotes monocyte survival
and induces monocyte differentiation into macrophages
Barbara Scheuerer,
Martin Ernst,
Iris Dürrbaum-Landmann,
Jens Fleischer,
Evelin Grage-Griebenow,
Ernst Brandt,
Hans-Dieter Flad, and
Frank Petersen
From the Department of Immunology and Cell Biology, Research Center
Borstel, D23845 Borstel, Germany.
Unstimulated monocytes rapidly undergo physiological changes
resulting in programmed cell death (apoptosis) while stimuli promoting
differentiation of these cells into macrophages were shown to inhibit
apoptotic processes. In the present study, we report that the
platelet-derived  -chemokine platelet factor 4 (PF4) induces the
differentiation of monocytes into macrophages, as is evident from
morphological changes as well as from the up-regulation of
differentiation markers (carboxypeptidase M/MAX1 and CD71). Significant
alterations of the phenotype were observed after 72 hours of culture in
the presence of the chemokine and required a minimal concentration of
625 nmol/L PF4. PF4-induced macrophages were characterized
by a lack of HLA-DR antigen on their surface but showed a strong
increase in the expression of the CD28 ligand B7-2. Furthermore, PF4
stimulation prevented monocytes from undergoing spontaneous apoptosis
during 72 hours of culture as determined in an annexin-V-binding
assay. Although PF4 induced the secretion of relevant amounts of
TNF-, neutralizing antibodies directed against TNF- or
granulocyte-macrophage colony-stimulating factor (GM-CSF) did not
revert PF4-induced rescue from programmed cell death, suggesting that
PF4 exerts its antiapoptotic effects in a TNF-- or
GM-CSF-independent fashion. On the basis of these results, we propose
a novel role for PF4 in the control of monocyte differentiation during
an inflammatory process in vivo.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. I. Borissoff, H. M.H. Spronk, S. Heeneman, and H. ten Cate
Is thrombin a key player in the 'coagulation-atherogenesis' maze?
Cardiovasc Res,
June 1, 2009;
82(3):
392 - 403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. van Gils, J. J. Zwaginga, and P. L. Hordijk
Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases
J. Leukoc. Biol.,
February 1, 2009;
85(2):
195 - 204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.J.W. Evans, L.E. Jackman, J. Chamberlain, D.J. Crosdale, H.M. Judge, K. Jetha, K.E. Norman, S.E. Francis, and R.F. Storey
Platelet P2Y12 Receptor Influences the Vessel Wall Response to Arterial Injury and Thrombosis
Circulation,
January 6, 2009;
119(1):
116 - 122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Gleissner, P. von Hundelshausen, and K. Ley
Platelet Chemokines in Vascular Disease
Arterioscler. Thromb. Vasc. Biol.,
November 1, 2008;
28(11):
1920 - 1927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Woller, E. Brandt, J. Mittelstadt, C. Rybakowski, and F. Petersen
Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals
J. Leukoc. Biol.,
April 1, 2008;
83(4):
936 - 945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tougan, H. Onda, D. Okuzaki, S. Kobayashi, H. Hashimoto, and H. Nojima
Focused Microarray Analysis of Peripheral Mononuclear Blood Cells from Churg-Strauss Syndrome Patients
DNA Res,
April 1, 2008;
15(2):
103 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Vandercappellen, S. Noppen, H. Verbeke, W. Put, R. Conings, M. Gouwy, E. Schutyser, P. Proost, R. Sciot, K. Geboes, et al.
Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells
J. Leukoc. Biol.,
December 1, 2007;
82(6):
1519 - 1530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Kasper, E. Brandt, S. Brandau, and F. Petersen
Platelet Factor 4 (CXC Chemokine Ligand 4) Differentially Regulates Respiratory Burst, Survival, and Cytokine Expression of Human Monocytes by Using Distinct Signaling Pathways
J. Immunol.,
August 15, 2007;
179(4):
2584 - 2591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Cho, P. Shashkin, C. A. Gleissner, D. Dunson, N. Jain, J. K. Lee, Y. Miller, and K. Ley
Induction of dendritic cell-like phenotype in macrophages during foam cell formation
Physiol Genomics,
April 24, 2007;
29(2):
149 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Chunsong, H. Yuling, W. Li, X. Jie, Z. Gang, Z. Qiuping, G. Qingping, Z. Kejian, Q. Li, A. E. Chang, et al.
CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells
J. Immunol.,
November 15, 2006;
177(10):
6713 - 6722.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yang, G. Mailhot, C. A. MacKay, A. Mason-Savas, J. Aubin, and P. R. Odgren
Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1{gamma}) in osteoclastogenesis in vivo and in vitro
Blood,
March 15, 2006;
107(6):
2262 - 2270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Kasper, E. Brandt, M. Ernst, and F. Petersen
Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases
Blood,
March 1, 2006;
107(5):
1768 - 1775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Schaffner, P. Rhyn, G. Schoedon, and D. J. Schaer
Regulated expression of platelet factor 4 in human monocytes--role of PARs as a quantitatively important monocyte activation pathway
J. Leukoc. Biol.,
July 1, 2005;
78(1):
202 - 209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Yu, A. H. Rux, P. Ma, K. Bdeir, and B. S. Sachais
Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-{kappa}B-dependent manner
Blood,
May 1, 2005;
105(9):
3545 - 3551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Weber
Platelets and Chemokines in Atherosclerosis: Partners in Crime
Circ. Res.,
April 1, 2005;
96(6):
612 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Y. Liu, M. Battaglia, S. H. Lee, Q.-H. Sun, R. H. Aster, and G. P. Visentin
Platelet Factor 4 Differentially Modulates CD4+CD25+ (Regulatory) versus CD4+CD25- (Nonregulatory) T Cells
J. Immunol.,
March 1, 2005;
174(5):
2680 - 2686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Qiuping, X. Jei, J. Youxin, J. Wei, L. Chun, W. Jin, W. Qun, L. Yan, H. Chunsong, Y. Mingzhen, et al.
CC Chemokine Ligand 25 Enhances Resistance to Apoptosis in CD4+ T Cells from Patients with T-Cell Lineage Acute and Chronic Lymphocytic Leukemia by Means of Livin Activation
Cancer Res.,
October 15, 2004;
64(20):
7579 - 7587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Akbiyik, D. M. Ray, K. F. Gettings, N. Blumberg, C. W. Francis, and R. P. Phipps
Human bone marrow megakaryocytes and platelets express PPAR{gamma}, and PPAR{gamma} agonists blunt platelet release of CD40 ligand and thromboxanes
Blood,
September 1, 2004;
104(5):
1361 - 1368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Pervushina, B. Scheuerer, N. Reiling, L. Behnke, Jens.-M. Schroder, B. Kasper, E. Brandt, S. Bulfone-Paus, and F. Petersen
Platelet Factor 4/CXCL4 Induces Phagocytosis and the Generation of Reactive Oxygen Metabolites in Mononuclear Phagocytes Independently of Gi Protein Activation or Intracellular Calcium Transients
J. Immunol.,
August 1, 2004;
173(3):
2060 - 2067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Kasper, E. Brandt, S. Bulfone-Paus, and F. Petersen
Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase
Blood,
March 1, 2004;
103(5):
1602 - 1610.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. T. Kozma, G. Losonczy, M. Keszei, Z. Komlosi, E. Buzas, E. Pallinger, J. Appel, T. Szabo, P. Magyar, A. Falus, et al.
Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE
Int. Immunol.,
August 1, 2003;
15(8):
963 - 973.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Q. Xia and K.-J. Kao
Effect of CXC chemokine platelet factor 4 on differentiation and function of monocyte-derived dendritic cells
Int. Immunol.,
August 1, 2003;
15(8):
1007 - 1015.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. van Grevenynghe, S. Rion, E. Le Ferrec, M. Le Vee, L. Amiot, R. Fauchet, and O. Fardel
Polycyclic Aromatic Hydrocarbons Inhibit Differentiation of Human Monocytes into Macrophages
J. Immunol.,
March 1, 2003;
170(5):
2374 - 2381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nassar, B. S. Sachais, S.'e. Akkawi, M. A. Kowalska, K. Bdeir, E. Leitersdorf, E. Hiss, L. Ziporen, M. Aviram, D. Cines, et al.
Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells
J. Biol. Chem.,
February 14, 2003;
278(8):
6187 - 6193.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Sulpice, M. Bryckaert, J. Lacour, J.-O. Contreres, and G. Tobelem
Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway
Blood,
October 16, 2002;
100(9):
3087 - 3094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Marti, E. Bertran, M. Llucia, E. Villen, M. Peiro, J. Garcia, and F. Rueda
Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8
J. Leukoc. Biol.,
September 1, 2002;
72(3):
590 - 597.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Fleischer, E. Grage-Griebenow, B. Kasper, H. Heine, M. Ernst, E. Brandt, H.-D. Flad, and F. Petersen
Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells
J. Immunol.,
July 15, 2002;
169(2):
770 - 777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Lang, F. Dohle, M. Terstesse, P. Bangen, C. August, H.-G. Pauels, and S. Heidenreich
Down-Regulation of Monocyte Apoptosis by Phagocytosis of Platelets: Involvement of a Caspase-9, Caspase-3, and Heat Shock Protein 70-Dependent Pathway
J. Immunol.,
June 15, 2002;
168(12):
6152 - 6158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Sachais, A. Kuo, T. Nassar, J. Morgan, K. Kariko, K. J. Williams, M. Feldman, M. Aviram, N. Shah, L. Jarett, et al.
Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic itinerary, resulting in retention of low-density lipoprotein on the cell surface
Blood,
May 15, 2002;
99(10):
3613 - 3622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-S. Bae, Y. Kim, J. C. Park, P.-G. Suh, and S. H. Ryu
The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation
J. Leukoc. Biol.,
February 1, 2002;
71(2):
329 - 338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Baran, K. Weglarczyk, M. Mysiak, K. Guzik, M. Ernst, H.-D. Flad, and J. Pryjma
Fas (CD95)-Fas Ligand Interactions Are Responsible for Monocyte Apoptosis Occurring as a Result of Phagocytosis and Killing of Staphylococcus aureus
Infect. Immun.,
March 1, 2001;
69(3):
1287 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Clemetson, J. M. Clemetson, A. E. I. Proudfoot, C. A. Power, M. Baggiolini, and T. N. C. Wells
Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
Blood,
December 15, 2000;
96(13):
4046 - 4054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
