|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 4 (February 15), 2000:
pp. 1317-1323
Leukocyte-leukocyte interactions mediated by platelet
microparticles under flow
Stephen B. Forlow,
Rodger P. McEver, and
Matthias
U. Nollert
From the School of Chemical Engineering and Materials Science,
University of Oklahoma, Norman, Oklahoma; the W. K. Warren Medical
Research Institute, Departments of Medicine and Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center,
Oklahoma City, Oklahoma; and the Cardiovascular Biology Research
Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Platelet microparticles (PMPs) are released from activated platelets
and express functional adhesion receptors, including P-selectin, on
their surface. PMP concentrations are elevated in many disorders, and
their role in accelerating coagulation has been studied. However, their
role in leukocyte aggregation has not been defined. We hypothesized
that P-selectin-expressing PMPs bridge leukocytes that express
P-selectin glycoprotein ligand-1 (PSGL-1), thereby allowing them to
interact under flow conditions. PMPs were isolated from platelet-rich
plasma or were generated by activating washed platelets with calcium
ionophore. PMPs increased transient adhesion of flowing
HL-60 cells or neutrophils to HL-60 cells or neutrophils
prebound to the surface of a parallel plate flow chamber. Homotypic
neutrophil interactions are initiated by the binding of L-selectin to
PSGL-1. However, even when L-selectin function was blocked, PMPs
allowed flowing neutrophils to aggregate and to interact with
PSGL-1-expressing cells prebound to the surface of the flow chamber.
The microparticle-mediated cell interactions occurred at lower shear
stresses than those mediated by L-selectin. PMPs may enhance
leukocyte aggregation and leukocyte accumulation on selectin-expressing
substrates, especially in diseases where the concentration of the
particles is elevated.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. C. Vedder, E. Biro, J. M. F. G. Aerts, R. Nieuwland, G. Sturk, and C. E. M. Hollak
Plasma markers of coagulation and endothelial activation in Fabry disease: impact of renal impairment
Nephrol. Dial. Transplant.,
June 10, 2009;
(2009)
gfp263v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Dasgupta, H. Abdel-Monem, P. Niravath, A. Le, R. V. Bellera, K. Langlois, S. Nagata, R. E. Rumbaut, and P. Thiagarajan
Lactadherin and clearance of platelet-derived microvesicles
Blood,
February 5, 2009;
113(6):
1332 - 1339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Montecucco and F. Mach
Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis
Rheumatology,
January 1, 2009;
48(1):
11 - 22.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Erdbruegger, M. Grossheim, B. Hertel, K. Wyss, T. Kirsch, A. Woywodt, H. Haller, and M. Haubitz
Diagnostic role of endothelial microparticles in vasculitis
Rheumatology,
December 1, 2008;
47(12):
1820 - 1825.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Xiao, G. P. Visentin, K. M. Dayananda, and S. Neelamegham
Immune complexes formed following the binding of anti-platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion
Blood,
August 15, 2008;
112(4):
1091 - 1100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Sprague, B. D. Elzey, S. A. Crist, T. J. Waldschmidt, R. J. Jensen, and T. L. Ratliff
Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles
Blood,
May 15, 2008;
111(10):
5028 - 5036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nolan, R. Dixon, K. Norman, P. Hellewell, and V. Ridger
Nitric Oxide Regulates Neutrophil Migration through Microparticle Formation
Am. J. Pathol.,
January 1, 2008;
172(1):
265 - 273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Salanova, M. Choi, S. Rolle, M. Wellner, F. C. Luft, and R. Kettritz
beta2-Integrins and Acquired Glycoprotein IIb/IIIa (GPIIb/IIIa) Receptors Cooperate in NF-{kappa}B Activation of Human Neutrophils
J. Biol. Chem.,
September 21, 2007;
282(38):
27960 - 27969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Othman, A. Labelle, I. Mazzetti, H. S. Elbatarny, and D. Lillicrap
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance
Blood,
April 1, 2007;
109(7):
2832 - 2839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Morel, F. Toti, B. Hugel, B. Bakouboula, L. Camoin-Jau, F. Dignat-George, and J.-M. Freyssinet
Procoagulant Microparticles: Disrupting the Vascular Homeostasis Equation?
Arterioscler. Thromb. Vasc. Biol.,
December 1, 2006;
26(12):
2594 - 2604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ichimura, K. Parthasarathi, A. C. Issekutz, and J. Bhattacharya
Pressure-induced leukocyte margination in lung postcapillary venules
Am J Physiol Lung Cell Mol Physiol,
September 1, 2005;
289(3):
L407 - L412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. F. Mause, P. von Hundelshausen, A. Zernecke, R. R. Koenen, and C. Weber
Platelet Microparticles: A Transcellular Delivery System for RANTES Promoting Monocyte Recruitment on Endothelium
Arterioscler. Thromb. Vasc. Biol.,
July 1, 2005;
25(7):
1512 - 1518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nomura, N. Inami, S. Kanazawa, T. Iwasaka, and S. Fukuhara
Elevation of Platelet Activation Markers and Chemokines during Peripheral Blood Stem Cell Harvest with G-CSF
Stem Cells,
September 1, 2004;
22(5):
696 - 703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Burdick and K. Konstantopoulos
Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow
Am J Physiol Cell Physiol,
August 1, 2004;
287(2):
C539 - C547.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hagihara, A. Higuchi, N. Tamura, Y. Ueda, K. Hirabayashi, Y. Ikeda, S. Kato, S. Sakamoto, T. Hotta, S. Handa, et al.
Platelets, after Exposure to a High Shear Stress, Induce IL-10-Producing, Mature Dendritic Cells In Vitro
J. Immunol.,
May 1, 2004;
172(9):
5297 - 5303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. VanWijk, E. VanBavel, A. Sturk, and R. Nieuwland
Microparticles in cardiovascular diseases
Cardiovasc Res,
August 1, 2003;
59(2):
277 - 287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. C. Burger and D. D. Wagner
Platelet P-selectin facilitates atherosclerotic lesion development
Blood,
April 1, 2003;
101(7):
2661 - 2666.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Preston, W. Jy, J. J. Jimenez, L. M. Mauro, L. L. Horstman, M. Valle, G. Aime, and Y. S. Ahn
Effects of Severe Hypertension on Endothelial and Platelet Microparticles
Hypertension,
February 1, 2003;
41(2):
211 - 217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kanamori, N. Kojima, K. Uchimura, T. Muramatsu, T. Tamatani, M. C. Berndt, G. S. Kansas, and R. Kannagi
Distinct Sulfation Requirements of Selectins Disclosed Using Cells That Support Rolling Mediated by All Three Selectins under Shear Flow. L-SELECTIN PREFERS CARBOHYDRATE 6-SULFATION TO TYROSINE SULFATION, WHEREAS P-SELECTIN DOES NOT
J. Biol. Chem.,
August 30, 2002;
277(36):
32578 - 32586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Huber, A. Vales, G. Mitulovic, M. Blumer, R. Schmid, J. L. Witztum, B. R. Binder, and N. Leitinger
Oxidized Membrane Vesicles and Blebs From Apoptotic Cells Contain Biologically Active Oxidized Phospholipids That Induce Monocyte-Endothelial Interactions
Arterioscler. Thromb. Vasc. Biol.,
January 1, 2002;
22(1):
101 - 107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Janowska-Wieczorek, M. Majka, J. Kijowski, M. Baj-Krzyworzeka, R. Reca, A. R. Turner, J. Ratajczak, S. G. Emerson, M. A. Kowalska, and M. Z. Ratajczak
Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment
Blood,
November 15, 2001;
98(10):
3143 - 3149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
