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Blood, Vol. 95 No. 4 (February 15), 2000:
pp. 1406-1412
HHV-8 is associated with a plasmablastic variant of Castleman
disease that is linked to HHV-8-positive plasmablastic lymphoma
Nicolas Dupin,
Tim L. Diss,
Paul Kellam,
Micheline Tulliez,
Ming-Qing Du,
Didier Sicard,
Robin A. Weiss,
Peter G. Isaacson, and
Chris Boshoff
From the Departments of Oncology, Molecular Pathology and
Histopathology, University College London, UK; Department of
Dermatology, NADER, Hopital Tarnier-Cochin, Paris; Department of
Histopathology and Internal Medicine, Hôpital Cochin, Paris,
France.
Castleman disease (CD) is a lymphoproliferative disorder of unknown
etiology that is associated with the development of secondary tumors,
including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's
sarcoma-associated herpesvirus) sequences have been described in some
cases of multicentric Castleman disease (MCD). Using a monoclonal
antibody against an HHV-8-latent nuclear antigen, we show that HHV-8
is specifically associated with a variant of MCD in which
HHV-8-positive plasmablasts that show  light-chain restriction
localize in the mantle zone of B-cell follicles and coalesce to form
microscopic lymphomas in some cases. Furthermore, we show that the
frank plasmablastic lymphoma that develops in patients with this
plasmablastic variant of MCD is also positive for HHV-8 and light
chain. Plasmablastic lymphoma associated with MCD is a new disease
entity associated with HHV-8 infection.
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