|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 4 (February 15), 2000:
pp. 1406-1412
HHV-8 is associated with a plasmablastic variant of Castleman
disease that is linked to HHV-8-positive plasmablastic lymphoma
Nicolas Dupin,
Tim L. Diss,
Paul Kellam,
Micheline Tulliez,
Ming-Qing Du,
Didier Sicard,
Robin A. Weiss,
Peter G. Isaacson, and
Chris Boshoff
From the Departments of Oncology, Molecular Pathology and
Histopathology, University College London, UK; Department of
Dermatology, NADER, Hopital Tarnier-Cochin, Paris; Department of
Histopathology and Internal Medicine, Hôpital Cochin, Paris,
France.
Castleman disease (CD) is a lymphoproliferative disorder of unknown
etiology that is associated with the development of secondary tumors,
including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's
sarcoma-associated herpesvirus) sequences have been described in some
cases of multicentric Castleman disease (MCD). Using a monoclonal
antibody against an HHV-8-latent nuclear antigen, we show that HHV-8
is specifically associated with a variant of MCD in which
HHV-8-positive plasmablasts that show  light-chain restriction
localize in the mantle zone of B-cell follicles and coalesce to form
microscopic lymphomas in some cases. Furthermore, we show that the
frank plasmablastic lymphoma that develops in patients with this
plasmablastic variant of MCD is also positive for HHV-8 and light
chain. Plasmablastic lymphoma associated with MCD is a new disease
entity associated with HHV-8 infection.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
Ly-1b cells and Castleman disease
- David M. Menke;, Peter G. Isaacson, and Chris Boshoff
Blood 2000 96: 1614-1616.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
B. Kelley-Clarke, E. De Leon-Vazquez, K. Slain, A. J. Barbera, and K. M. Kaye
Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence
J. Virol.,
May 1, 2009;
83(9):
4326 - 4337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Wang, M. Pietrek, M. M. Brinkmann, A. Havemeier, I. Fischer, B. Hillenbrand, O. Dittrich-Breiholz, M. Kracht, S. Chanas, D. J. Blackbourn, et al.
Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus
J. Gen. Virol.,
May 1, 2009;
90(5):
1190 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carbone, E. Cesarman, M. Spina, A. Gloghini, and T. F. Schulz
HIV-associated lymphomas and gamma-herpesviruses
Blood,
February 5, 2009;
113(6):
1213 - 1224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kojima, N. Nakamura, N. Tsukamoto, Y. Otuski, K. Shimizu, H. Itoh, S. Kobayashi, H. Kobayashi, T. Murase, N. Masawa, et al.
Clinical Implications of Idiopathic Multicentric Castleman Disease Among Japanese: A Report of 28 Cases
International Journal of Surgical Pathology,
October 1, 2008;
16(4):
391 - 398.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Bower, T. Powles, S. Williams, T. N. Davis, M. Atkins, S. Montoto, C. Orkin, A. Webb, M. Fisher, M. Nelson, et al.
Brief Communication: Rituximab in HIV-Associated Multicentric Castleman Disease
Ann Intern Med,
December 18, 2007;
147(12):
836 - 839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Wilson, E. H. Tsao, B. L. J. Webb, H. Ye, L. Dalton-Griffin, C. Tsantoulas, C. V. Gale, M.-Q. Du, A. Whitehouse, and P. Kellam
X Box Binding Protein XBP-1s Transactivates the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF50 Promoter, Linking Plasma Cell Differentiation to KSHV Reactivation from Latency
J. Virol.,
December 15, 2007;
81(24):
13578 - 13586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M-Q Du, C M Bacon, and P G Isaacson
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders
J. Clin. Pathol.,
December 1, 2007;
60(12):
1350 - 1357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K L Grogg, R F Miller, and A Dogan
HIV infection and lymphoma
J. Clin. Pathol.,
December 1, 2007;
60(12):
1365 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Liu, H. J. Martin, G. Liao, and S. D. Hayward
The Kaposi's Sarcoma-Associated Herpesvirus LANA Protein Stabilizes and Activates c-Myc
J. Virol.,
October 1, 2007;
81(19):
10451 - 10459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Prakash and S. H Swerdlow
Nodal aggressive B-cell lymphomas: a diagnostic approach
J. Clin. Pathol.,
October 1, 2007;
60(10):
1076 - 1085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Kelley-Clarke, M. E. Ballestas, V. Srinivasan, A. J. Barbera, T. Komatsu, T.-A. Harris, M. Kazanjian, and K. M. Kaye
Determination of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal Latency-Associated Nuclear Antigen Residues Mediating Chromosome Association and DNA Binding
J. Virol.,
April 15, 2007;
81(8):
4348 - 4356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Verma, T. Choudhuri, and E. S. Robertson
The Minimal Replicator Element of the Kaposi's Sarcoma-Associated Herpesvirus Terminal Repeat Supports Replication in a Semiconservative and Cell-Cycle-Dependent Manner
J. Virol.,
April 1, 2007;
81(7):
3402 - 3413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Nascimento, V. A. de Souza, L. M. Sumita, W. Freire, F. Munoz, J. Kim, C. S. Pannuti, and P. Mayaud
Comparative Study of Kaposi's Sarcoma-Associated Herpesvirus Serological Assays Using Clinically and Serologically Defined Reference Standards and Latent Class Analysis
J. Clin. Microbiol.,
March 1, 2007;
45(3):
715 - 720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Verma, B. G. Bajaj, Q. Cai, H. Si, T. Seelhammer, and E. S. Robertson
Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Recruits Uracil DNA Glycosylase 2 at the Terminal Repeats and Is Important for Latent Persistence of the Virus
J. Virol.,
November 15, 2006;
80(22):
11178 - 11190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. T. Scadden, V. V. Muse, and R. P. Hasserjian
Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy.
N. Engl. J. Med.,
September 28, 2006;
355(13):
1358 - 1368.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Verma, K. Lan, T. Choudhuri, and E. S. Robertson
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Modulates K1 Expression through Its cis-Acting Elements within the Terminal Repeats.
J. Virol.,
April 1, 2006;
80(7):
3445 - 3458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Thaunat, M.-F. Mamzer-Bruneel, F. Agbalika, F. Valensi, M. Venditto, C. Lebbe, C. Frances, R. Kania, L. Chatenoud, C. Antoine, et al.
Severe human herpesvirus-8 primary infection in a renal transplant patient successfully treated with anti-CD20 monoclonal antibody.
Blood,
April 1, 2006;
107(7):
3009 - 3010.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cannon, E. Cesarman, and C. Boshoff
KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2
Blood,
January 1, 2006;
107(1):
277 - 284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dogan, M.-Q. Du, P. G. Isaacson, L. Dagna, J. Rosai, and P. Lusso
A relapsing inflammatory syndrome and HHV-8.
N. Engl. J. Med.,
October 20, 2005;
353(16):
1746 - 1747.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Trento, C. Castilletti, C. Ferraro, I. Lesnoni La Parola, A. Mussi, L. Muscardin, V. Bordignon, G. D'Agosto, A. Amantea, A. Mastroianni, et al.
Human Herpesvirus 8 Infection in Patients With Cutaneous Lymphoproliferative Diseases
Arch Dermatol,
October 1, 2005;
141(10):
1235 - 1242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Carbone, A Gloghini, E Vaccher, G Marchetti, G Gaidano, and U Tirelli
KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype
J. Clin. Pathol.,
October 1, 2005;
58(10):
1039 - 1045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. O. Willer and S. H. Speck
Establishment and Maintenance of Long-Term Murine Gammaherpesvirus 68 Latency in B Cells in the Absence of CD40
J. Virol.,
March 1, 2005;
79(5):
2891 - 2899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carbone, A. Gloghini, E. Vaccher, M. Cerri, G. Gaidano, R. Dalla-Favera, and U. Tirelli
Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus Type 8-Positive Solid Lymphomas: A Tissue-Based Variant of Primary Effusion Lymphoma
J. Mol. Diagn.,
February 1, 2005;
7(1):
17 - 27.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Meads and P. G. Medveczky
Kaposi's Sarcoma-associated Herpesvirus-encoded Viral Interleukin-6 Is Secreted and Modified Differently Than Human Interleukin-6: EVIDENCE FOR A UNIQUE AUTOCRINE SIGNALING MECHANISM
J. Biol. Chem.,
December 10, 2004;
279(50):
51793 - 51803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Teruya-Feldstein, E. Chiao, D. A. Filippa, O. Lin, R. Comenzo, M. Coleman, C. Portlock, and A. Noy
CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients
Ann. Onc.,
November 1, 2004;
15(11):
1673 - 1679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Borah, S. C. Verma, and E. S. Robertson
ORF73 of Herpesvirus Saimiri, a Viral Homolog of Kaposi's Sarcoma-Associated Herpesvirus, Modulates the Two Cellular Tumor Suppressor Proteins p53 and pRb
J. Virol.,
October 1, 2004;
78(19):
10336 - 10347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Guasparri, S. A. Keller, and E. Cesarman
KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells
J. Exp. Med.,
April 5, 2004;
199(7):
993 - 1003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. McClain, Y. Natkunam, and S. H. Swerdlow
Atypical Cellular Disorders
Hematology,
January 1, 2004;
2004(1):
283 - 296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Verma and E. S. Robertson
ORF73 of Herpesvirus Saimiri Strain C488 Tethers the Viral Genome to Metaphase Chromosomes and Binds to cis-Acting DNA Sequences in the Terminal Repeats
J. Virol.,
December 1, 2003;
77(23):
12494 - 12506.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Goedert
Multicentric Castleman disease: viral and cellular targets for intervention
Blood,
October 15, 2003;
102(8):
2710 - 2711.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-G. Marcelin, L. Aaron, C. Mateus, E. Gyan, I. Gorin, J.-P. Viard, V. Calvez, and N. Dupin
Rituximab therapy for HIV-associated Castleman disease
Blood,
October 15, 2003;
102(8):
2786 - 2788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Jenner, K. Maillard, N. Cattini, R. A. Weiss, C. Boshoff, R. Wooster, and P. Kellam
Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
PNAS,
September 2, 2003;
100(18):
10399 - 10404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Tomescu, W. K. Law, and D. H. Kedes
Surface Downregulation of Major Histocompatibility Complex Class I, PE-CAM, and ICAM-1 following De Novo Infection of Endothelial Cells with Kaposi's Sarcoma-Associated Herpesvirus
J. Virol.,
September 1, 2003;
77(17):
9669 - 9684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I.-J. Kim, E. Flano, D. L. Woodland, F. E. Lund, T. D. Randall, and M. A. Blackman
Maintenance of Long Term {gamma}-Herpesvirus B Cell Latency Is Dependent on CD40-Mediated Development of Memory B Cells
J. Immunol.,
July 15, 2003;
171(2):
886 - 892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Volberding, K. R. Baker, and A. M. Levine
Human Immunodeficiency Virus Hematology
Hematology,
January 1, 2003;
2003(1):
294 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cannon, N. J. Philpott, and E. Cesarman
The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells
J. Virol.,
December 6, 2002;
77(1):
57 - 67.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shinohara, M. Fukushi, M. Higuchi, M. Oie, O. Hoshi, T. Ushiki, J.-I. Hayashi, and M. Fujii
Chromosome Binding Site of Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Is Essential for Persistent Episome Maintenance and Is Functionally Replaced by Histone H1
J. Virol.,
November 13, 2002;
76(24):
12917 - 12924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-Q. Du, T. C. Diss, H. Liu, H. Ye, R. A. Hamoudi, J. Cabecadas, H. Y. Dong, N. L. Harris, J. K. C. Chan, J. W. Rees, et al.
KSHV- and EBV-associated germinotropic lymphoproliferative disorder
Blood,
October 16, 2002;
100(9):
3415 - 3418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Krithivas, M. Fujimuro, M. Weidner, D. B. Young, and S. D. Hayward
Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes
J. Virol.,
October 11, 2002;
76(22):
11596 - 11604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Garber, J. Hu, and R. Renne
Latency-associated Nuclear Antigen (LANA) Cooperatively Binds to Two Sites within the Terminal Repeat, and Both Sites Contribute to the Ability of LANA to Suppress Transcription and to Facilitate DNA Replication
J. Biol. Chem.,
July 19, 2002;
277(30):
27401 - 27411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Oksenhendler, E. Boulanger, L. Galicier, M.-Q. Du, N. Dupin, T. C. Diss, R. Hamoudi, M.-T. Daniel, F. Agbalika, C. Boshoff, et al.
High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease
Blood,
April 1, 2002;
99(7):
2331 - 2336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. V. Sharp, H.-W. Wang, A. Koumi, D. Hollyman, Y. Endo, H. Ye, M.-Q. Du, and C. Boshoff
K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus Is Latently Expressed and Binds to HAX-1, a Protein with Antiapoptotic Function
J. Virol.,
January 15, 2002;
76(2):
802 - 816.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Corbellino, G. Bestetti, C. Scalamogna, S. Calattini, M. Galazzi, L. Meroni, D. Manganaro, M. Fasan, M. Moroni, M. Galli, et al.
Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy
Blood,
December 1, 2001;
98(12):
3473 - 3475.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E Caussinus, F Meggetto, G Delsol, and P Brousset
Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event?
J. Clin. Pathol.,
October 1, 2001;
54(10):
790 - 791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Garber, M. A. Shu, J. Hu, and R. Renne
DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
J. Virol.,
September 1, 2001;
75(17):
7882 - 7892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Gomez-Brouchet, M B Delisle, A Vital, and P Brousset
Immunohistochemical assessment of human herpesvirus 8 infection in primary central nervous system large B cell lymphomas
J. Clin. Pathol.,
August 1, 2001;
54(8):
617 - 618.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Piolot, M. Tramier, M. Coppey, J.-C. Nicolas, and V. Marechal
Close but Distinct Regions of Human Herpesvirus 8 Latency-Associated Nuclear Antigen 1 Are Responsible for Nuclear Targeting and Binding to Human Mitotic Chromosomes
J. Virol.,
April 15, 2001;
75(8):
3948 - 3959.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M.-Q. Du, H. Liu, T. C. Diss, H. Ye, R. A. Hamoudi, N. Dupin, V. Meignin, E. Oksenhendler, C. Boshoff, and P. G. Isaacson
Kaposi sarcoma-associated herpesvirus infects monotypic (IgM{lambda}) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders
Blood,
April 1, 2001;
97(7):
2130 - 2136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Low, M. Harries, H. Ye, M.-Q. Du, C. Boshoff, and M. Collins
Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein
J. Virol.,
March 15, 2001;
75(6):
2938 - 2945.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Pan, L. Milligan, J. Michaeli, E. Cesarman, and D. M. Knowles
Polymerase Chain Reaction Detection of Kaposi's Sarcoma-Associated Herpesvirus-Optimized Protocols and Their Application to Myeloma
J. Mol. Diagn.,
February 1, 2001;
3(1):
32 - 38.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. G. Jenner, M. M. Albà, C. Boshoff, and P. Kellam
Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays
J. Virol.,
January 15, 2001;
75(2):
891 - 902.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Krithivas, D. B. Young, G. Liao, D. Greene, and S. D. Hayward
Human Herpesvirus 8 LANA Interacts with Proteins of the mSin3 Corepressor Complex and Negatively Regulates Epstein-Barr Virus Gene Expression in Dually Infected PEL Cells
J. Virol.,
October 15, 2000;
74(20):
9637 - 9645.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Powles, G. Matthews, and M. Bower
AIDS related systemic non-Hodgkin's lymphoma
Sex Transm Inf,
October 1, 2000;
76(5):
335 - 341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Oksenhendler, G. Carcelain, Y. Aoki, E. Boulanger, A. Maillard, J.-P. Clauvel, and F. Agbalika
High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients
Blood,
September 15, 2000;
96(6):
2069 - 2073.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Menke;, P. G. Isaacson, and C. Boshoff
Ly-1b cells and Castleman disease
Blood,
August 15, 2000;
96(4):
1614 - 1616.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Weiss and C. Boshoff
Addressing Controversies Over Kaposi's Sarcoma
J Natl Cancer Inst,
May 3, 2000;
92(9):
677 - 679.
[Full Text]
[PDF]
|
|
|
|
|
