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Blood, Vol. 95 No. 4 (February 15), 2000:
pp. 1506-1508
BRIEF REPORT
The Exodus subfamily of CC chemokines inhibits the
proliferation of chronic myelogenous leukemia progenitors
Robert Hromas,
Larry Cripe,
Giao Hangoc,
Scott Cooper, and
Hal E. Broxmeyer
From Hematology/Oncology, Biochemistry/Molecular Biology,
Microbiology/Immunology, and the Walther Oncology Center, Indiana
University Medical Center, Indianapolis, Indiana.
Chemokines are a family of related proteins that regulate leukocyte
infiltration into inflamed tissue and play important roles in disease
processes. Among the biologic activities of chemokines is inhibition of
proliferation of normal hematopoietic progenitors. However, chemokines
that inhibit normal progenitors rarely inhibit proliferation of
hematopoietic progenitors from patients with chronic myelogenous
leukemia (CML). We and others recently cloned a subfamily of CC
chemokines that share similar amino-terminal peptide sequences and a
remarkable ability to chemoattract T cells. These chemokines,
Exodus-1/LARC/MIP-3 , Exodus-2/SLC/6Ckine/TCA4, and
Exodus-3/CK 11/MIP-3, were found to inhibit proliferation of
normal human marrow progenitors. The study described here found that
these chemokines also inhibited the proliferation of progenitors in
every sample of marrow from patients with CML that was tested. This
demonstration of consistent inhibition of CML progenitor proliferation
makes the 3 Exodus chemokines unique among chemokines.
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