|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 6 (March 15), 2000:
pp. 1891-1899
PLENARY PAPER
Evidence that tristetraprolin is a physiological regulator of
granulocyte-macrophage colony-stimulating factor messenger RNA
deadenylation and stability
Ester Carballo,
Wi S. Lai, and
Perry J. Blackshear
From the Office of Clinical Research and Laboratory of Signal
Transduction, National Institute of Environmental Health Sciences,
Research Triangle Park, NC, and Departments of Medicine and
Biochemistry, Duke University Medical Center, Durham, NC.
Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc
finger proteins, results in a complex inflammatory syndrome in mice.
Most aspects of the syndrome are secondary to excess circulating tumor
necrosis factor (TNF)- , a consequence of increased stability of
TNF- messenger RNA (mRNA) in TTP-deficient macrophages. TTP can bind
directly to the AU-rich element in TNF- mRNA, increasing its
lability. Here we show that TTP deficiency also results in increased
cellular production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and increased stability of its mRNA, apparently secondary to decreased deadenylation. Similar findings were observed in
mice also lacking both types of TNF- receptors, excluding excess
TNF- production as a cause of the increased GM-CSF mRNA levels and
stability. TTP appears to be a physiological regulator of GM-CSF mRNA
deadenylation and stability.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. M. Rowlett, C. A. Chrestensen, M. J. Schroeder, M. G. Harp, J. W. Pelo, J. Shabanowitz, R. DeRose, D. F. Hunt, T. W. Sturgill, and M. T. Worthington
Inhibition of tristetraprolin deadenylation by poly(A) binding protein
Am J Physiol Gastrointest Liver Physiol,
September 1, 2008;
295(3):
G421 - G430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Jalonen, E.-L. Paukkeri, and E. Moilanen
Compounds That Increase or Mimic Cyclic Adenosine Monophosphate Enhance Tristetraprolin Degradation in Lipopolysaccharide-Treated Murine J774 Macrophages
J. Pharmacol. Exp. Ther.,
August 1, 2008;
326(2):
514 - 522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. S. Hartz, B. Bauer, M. L. Block, J.-S. Hong, and D. S. Miller
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier
FASEB J,
August 1, 2008;
22(8):
2723 - 2733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. T. Ishmael, X. Fang, M. R. Galdiero, U. Atasoy, W. F. C. Rigby, M. Gorospe, C. Cheadle, and C. Stellato
Role of the RNA-Binding Protein Tristetraprolin in Glucocorticoid-Mediated Gene Regulation
J. Immunol.,
June 15, 2008;
180(12):
8342 - 8353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Emmons, W.H. D. Townley-Tilson, K. M. Deleault, S. J. Skinner, R. H. Gross, M. L. Whitfield, and S. A. Brooks
Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
RNA,
May 1, 2008;
14(5):
888 - 902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kandasamy and A. S. Kraft
Proteasome inhibitor PS-341 (VELCADE) induces stabilization of the TRAIL receptor DR5 mRNA through the 3'-untranslated region
Mol. Cancer Ther.,
May 1, 2008;
7(5):
1091 - 1100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cao, J. F. Urban Jr, and R. A. Anderson
Cinnamon Polyphenol Extract Affects Immune Responses by Regulating Anti- and Proinflammatory and Glucose Transporter Gene Expression in Mouse Macrophages
J. Nutr.,
May 1, 2008;
138(5):
833 - 840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Stoecklin, S. A. Tenenbaum, T. Mayo, S. V. Chittur, A. D. George, T. E. Baroni, P. J. Blackshear, and P. Anderson
Genome-wide Analysis Identifies Interleukin-10 mRNA as Target of Tristetraprolin
J. Biol. Chem.,
April 25, 2008;
283(17):
11689 - 11699.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Datta, R. Biswas, M. Novotny, P. G. Pavicic Jr., T. Herjan, P. Mandal, and T. A. Hamilton
Tristetraprolin Regulates CXCL1 (KC) mRNA Stability
J. Immunol.,
February 15, 2008;
180(4):
2545 - 2552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Cuthbertson, Y. Liao, L. Birnbaumer, and P. J. Blackshear
Characterization of zfs1 as an mRNA-binding and -destabilizing Protein in Schizosaccharomyces pombe
J. Biol. Chem.,
February 1, 2008;
283(5):
2586 - 2594.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Essafi-Benkhadir, C. Onesto, E. Stebe, C. Moroni, and G. Pages
Tristetraprolin Inhibits Ras-dependent Tumor Vascularization by Inducing Vascular Endothelial Growth Factor mRNA Degradation
Mol. Biol. Cell,
November 1, 2007;
18(11):
4648 - 4658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.S. Patil and K.L. Kirkwood
p38 MAPK Signaling in Oral-related Diseases
Journal of Dental Research,
September 1, 2007;
86(9):
812 - 825.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. David, R. Tanveer, and J. D. Port
FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1
RNA,
September 1, 2007;
13(9):
1453 - 1468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Sun, H. Jiang, Y. Xu, H. Li, X. Wu, Q. Xie, and C. Li
The CCCH-Type Zinc Finger Proteins AtSZF1 and AtSZF2 Regulate Salt Stress Responses in Arabidopsis
Plant Cell Physiol.,
August 1, 2007;
48(8):
1148 - 1158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Frasca, A. M. Landin, J. P. Alvarez, P. J. Blackshear, R. L. Riley, and B. B. Blomberg
Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA
J. Immunol.,
July 15, 2007;
179(2):
918 - 927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Korhonen, K. Linker, A. Pautz, U. Forstermann, E. Moilanen, and H. Kleinert
Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase
Mol. Pharmacol.,
May 1, 2007;
71(5):
1427 - 1434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Franks and J. Lykke-Andersen
TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements
Genes & Dev.,
March 15, 2007;
21(6):
719 - 735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakayama, N. Mutsuga, and G. Tosato
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc
Blood,
February 15, 2007;
109(4):
1363 - 1372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sun, G. Stoecklin, S. Van Way, V. Hinkovska-Galcheva, R.-F. Guo, P. Anderson, and T. P. Shanley
Tristetraprolin (TTP)-14-3-3 Complex Formation Protects TTP from Dephosphorylation by Protein Phosphatase 2a and Stabilizes Tumor Necrosis Factor-{alpha} mRNA
J. Biol. Chem.,
February 9, 2007;
282(6):
3766 - 3777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Lai, J. S. Parker, S. F. Grissom, D. J. Stumpo, and P. J. Blackshear
Novel mRNA Targets for Tristetraprolin (TTP) Identified by Global Analysis of Stabilized Transcripts in TTP-Deficient Fibroblasts
Mol. Cell. Biol.,
December 15, 2006;
26(24):
9196 - 9208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Smoak and J. A. Cidlowski
Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling
Mol. Cell. Biol.,
December 1, 2006;
26(23):
9126 - 9135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Esnault, Z.-J. Shen, E. Whitesel, and J. S. Malter
The Peptidyl-Prolyl Isomerase Pin1 Regulates Granulocyte-Macrophage Colony-Stimulating Factor mRNA Stability in T Lymphocytes
J. Immunol.,
November 15, 2006;
177(10):
6999 - 7006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Lu, N. Sadri, and R. J. Schneider
Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs
Genes & Dev.,
November 15, 2006;
20(22):
3174 - 3184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Fawal, F. Armstrong, S. Ollier, H. Dupont, C. Touriol, B. Monsarrat, G. Delsol, B. Payrastre, and D. Morello
A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK
Blood,
October 15, 2006;
108(8):
2780 - 2788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Kritikou, S. Milstein, P.-O. Vidalain, G. Lettre, E. Bogan, K. Doukoumetzidis, P. Gray, T. G. Chappell, M. Vidal, and M. O. Hengartner
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival.
Genes & Dev.,
August 15, 2006;
20(16):
2279 - 2292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Kong, M. Li, W. Yang, W. Xu, and Y. Xue
A Novel Nuclear-Localized CCCH-Type Zinc Finger Protein, OsDOS, Is Involved in Delaying Leaf Senescence in Rice
Plant Physiology,
August 1, 2006;
141(4):
1376 - 1388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Sauer, B. Schaljo, C. Vogl, I. Gattermeier, T. Kolbe, M. Muller, P. J. Blackshear, and P. Kovarik
Interferons limit inflammatory responses by induction of tristetraprolin
Blood,
June 15, 2006;
107(12):
4790 - 4797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Giembycz and R. Newton
Beyond the dogma: novel {beta}2-adrenoceptor signalling in the airways.
Eur. Respir. J.,
June 1, 2006;
27(6):
1286 - 1306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Lu, N. Bergman, N. Sadri, and R. J. Schneider
Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay
RNA,
May 1, 2006;
12(5):
883 - 893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jurado, F. Rodriguez-Pascual, J. Sanchez-Prieto, F. M. Reimunde, S. Lamas, and M. Torres
NMDA induces post-transcriptional regulation of {alpha}2-guanylyl-cyclase-subunit expression in cerebellar granule cells
J. Cell Sci.,
April 15, 2006;
119(8):
1622 - 1631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Brook, C. R. Tchen, T. Santalucia, J. McIlrath, J. S. C. Arthur, J. Saklatvala, and A. R. Clark
Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways.
Mol. Cell. Biol.,
March 1, 2006;
26(6):
2408 - 2418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Wang, M. Collinge, V. Ramgolam, O. Ayalon, X. C. Fan, R. Pardi, and J. R. Bender
LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation
J. Immunol.,
February 15, 2006;
176(4):
2105 - 2113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Barreau, L. Paillard, and H. B. Osborne
AU-rich elements and associated factors: are there unifying principles?
Nucleic Acids Res.,
January 3, 2006;
33(22):
7138 - 7150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Lai, D. M. Carrick, and P. J. Blackshear
Influence of Nonameric AU-rich Tristetraprolin-binding Sites on mRNA Deadenylation and Turnover
J. Biol. Chem.,
October 7, 2005;
280(40):
34365 - 34377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-L. Hsu, H. A. Saffran, and J. R. Smiley
Herpes Simplex Virus Infection Stabilizes Cellular IEX-1 mRNA
J. Virol.,
April 1, 2005;
79(7):
4090 - 4098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bardin, F. Moll, R. Margueron, C. Delfour, M. L. Chu, T. Maudelonde, V. Cavailles, and P. Pujol
Transcriptional and Posttranscriptional Regulation of Fibulin-1 by Estrogens Leads to Differential Induction of Messenger Ribonucleic Acid Variants in Ovarian and Breast Cancer Cells
Endocrinology,
February 1, 2005;
146(2):
760 - 768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Ogilvie, M. Abelson, H. H. Hau, I. Vlasova, P. J. Blackshear, and P. R. Bohjanen
Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay
J. Immunol.,
January 15, 2005;
174(2):
953 - 961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. R. Tchen, M. Brook, J. Saklatvala, and A. R. Clark
The Stability of Tristetraprolin mRNA Is Regulated by Mitogen-activated Protein Kinase p38 and by Tristetraprolin Itself
J. Biol. Chem.,
July 30, 2004;
279(31):
32393 - 32400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Stumpo, N. A. Byrd, R. S. Phillips, S. Ghosh, R. R. Maronpot, T. Castranio, E. N. Meyers, Y. Mishina, and P. J. Blackshear
Chorioallantoic Fusion Defects and Embryonic Lethality Resulting from Disruption of Zfp36L1, a Gene Encoding a CCCH Tandem Zinc Finger Protein of the Tristetraprolin Family
Mol. Cell. Biol.,
July 15, 2004;
24(14):
6445 - 6455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Anderson, K. Phillips, G. Stoecklin, and N. Kedersha
Post-transcriptional regulation of proinflammatory proteins
J. Leukoc. Biol.,
July 1, 2004;
76(1):
42 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Brooks, J. E. Connolly, and W. F. C. Rigby
The Role of mRNA Turnover in the Regulation of Tristetraprolin Expression: Evidence for an Extracellular Signal-Regulated Kinase-Specific, AU-Rich Element-Dependent, Autoregulatory Pathway
J. Immunol.,
June 15, 2004;
172(12):
7263 - 7271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cao, J. S. Tuttle, and P. J. Blackshear
Immunological Characterization of Tristetraprolin as a Low Abundance, Inducible, Stable Cytosolic Protein
J. Biol. Chem.,
May 14, 2004;
279(20):
21489 - 21499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
