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Blood, Vol. 95 No. 7 (April 1), 2000:
pp. 2346-2351
In vitro growth inhibition of a broad spectrum of tumor cell
lines by activated human dendritic cells
Andrei I. Chapoval,
Koji Tamada, and
Lieping Chen
From the Department of Immunology, Mayo Graduate and Medical
Schools, Mayo Clinic, Rochester, MN.
Dendritic cells (DCs) are critical subsets of leukocytes providing
antigen presentation for initiation of humoral and cellular immune
responses. Their role as effector cells in tumor resistance, however,
is less known. We report here that human DCs generated by culturing
plastic-adherent peripheral blood monocytes in the presence of granulocyte-monocyte colony-stimulating factor (GM-CSF) and interleukin-4 have potent growth-inhibition activity
in vitro on a wide spectrum of human tumor lines of
different tissue origin. Proinflammatory stimuli lipopolysaccharide
(LPS) and interferon- , but not tumor necrosis factor- and CD40
signaling, can further enhance DC-mediated inhibition of tumor growth.
The growth inhibition requires contact between DCs and tumor
cells while LPS treatment enhances the antitumor activity in DC
culture supernatants. Our results suggest that in addition to their
predominant role as regulatory cells, activated DCs are also potential
effector cells in tumor immunity.
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