|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 8 (April 15), 2000:
pp. 2505-2513
Stromal cell-derived factor-1 stimulates tyrosine
phosphorylation of multiple focal adhesion proteins and induces
migration of hematopoietic progenitor cells: roles of
phosphoinositide-3 kinase and protein kinase C
Jian-Feng Wang,
In-Woo Park, and
Jerome E. Groopman
From the Divisions of Experimental Medicine and Hematology/Oncology,
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston,
MA.
The stromal cell-derived factor-1 (SDF-1) is an alpha chemokine that
binds to the CXCR4 receptor. Knock-out studies in mice demonstrate that
this ligand-receptor pair is essential in hematopoiesis. One function
of SDF-1 appears to be the regulation of migration of hematopoietic
progenitor cells. We previously characterized signal transduction
pathways induced by SDF-1 in human hematopoietic progenitors and
found tyrosine phosphorylation of focal adhesion components, including
the related adhesion focal tyrosine kinase (RAFTK), the adaptor
molecule p130 Cas, and the cytoskeletal protein paxillin. To better
understand the functional role of signaling molecules connecting the
CXCR4 receptor to the process of hematopoietic migration, we studied
SDF-1-mediated pathways in a model hematopoietic progenitor cell
line (CTS), as well as in primary human bone marrow CD34+
cells. We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and
Crk-L, are phosphorylated on SDF-1 stimulation. Using a series of
specific small molecule inhibitors, both protein kinase C (PKC) and
phosphoinositide-3 kinase (PI-3K) appeared to be required for
SDF-1-mediated phosphorylation of focal adhesion proteins and the
migration of both CTS and primary marrow CD34+ cells,
whereas the mitogen-activated protein kinases ERK-1 and -2 were not.
These studies further delineate the molecular pathways mediating
hematopoietic progenitor migration and response to an essential
chemokine, SDF-1.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Kasorn, P. Alcaide, Y. Jia, K. K. Subramanian, B. Sarraj, Y. Li, F. Loison, H. Hattori, L. E. Silberstein, W. F. Luscinskas, et al.
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals
J. Immunol.,
July 15, 2009;
183(2):
1032 - 1043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sen, L. Lv, N. Bello, J. J. Ireland, and G. W. Smith
Cocaine- and Amphetamine-Regulated Transcript Accelerates Termination of Follicle-Stimulating Hormone-Induced Extracellularly Regulated Kinase 1/2 and Akt Activation by Regulating the Expression and Degradation of Specific Mitogen-Activated Protein Kinase Phosphatases in Bovine Granulosa Cells
Mol. Endocrinol.,
December 1, 2008;
22(12):
2655 - 2676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Lagane, K. Y. C. Chow, K. Balabanian, A. Levoye, J. Harriague, T. Planchenault, F. Baleux, N. Gunera-Saad, F. Arenzana-Seisdedos, and F. Bachelerie
CXCR4 dimerization and {beta}-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome
Blood,
July 1, 2008;
112(1):
34 - 44.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. J. de Gorter, R. M. Reijmers, E. A. Beuling, H. P. H. Naber, A. Kuil, M. J. Kersten, S. T. Pals, and M. Spaargaren
The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells
Blood,
April 1, 2008;
111(7):
3364 - 3372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E Corcoran, A. Malhotra, C. A Molina, and P. Rameshwar
Stromal-derived factor-1{alpha} induces a non-canonical pathway to activate the endocrine-linked Tac1 gene in non-tumorigenic breast cells
J. Mol. Endocrinol.,
March 1, 2008;
40(3):
113 - 123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Jin, Y. Tabe, S. Konoplev, Y. Xu, C. E. Leysath, H. Lu, S. Kimura, A. Ohsaka, M.-B. Rios, L. Calvert, et al.
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
Mol. Cancer Ther.,
January 1, 2008;
7(1):
48 - 58.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Fuhler, A. L. Drayer, S. G. M. Olthof, J. J. Schuringa, P. J. Coffer, and E. Vellenga
Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia
Blood,
January 1, 2008;
111(1):
359 - 368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Patrussi, C. Ulivieri, O. M. Lucherini, S. R. Paccani, A. Gamberucci, L. Lanfrancone, P. G. Pelicci, and C. T. Baldari
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells
Blood,
September 15, 2007;
110(6):
1730 - 1738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Bach, Q.-M. Chen, W. T. Kerr, Y. Wang, L. Lian, J. K. Choi, D. Wu, M. G. Kazanietz, G. A. Koretzky, S. Zigmond, et al.
Phospholipase Cbeta Is Critical for T Cell Chemotaxis
J. Immunol.,
August 15, 2007;
179(4):
2223 - 2227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Park, I. Park, D. Lee, Y. B. Choi, H. Lee, and Y. Yun
The adaptor protein Lad associates with the G protein {beta} subunit and mediates chemokine-dependent T-cell migration
Blood,
June 15, 2007;
109(12):
5122 - 5128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Corcoran and P. Rameshwar
Nuclear Factor-{kappa}B Accounts for the Repressor Effects of High Stromal Cell-Derived Factor-1{alpha} Levels on Tac1 Expression in Nontumorigenic Breast Cells
Mol. Cancer Res.,
April 1, 2007;
5(4):
373 - 381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Alsayed, H. Ngo, J. Runnels, X. Leleu, U. K. Singha, C. M. Pitsillides, J. A. Spencer, T. Kimlinger, J. M. Ghobrial, X. Jia, et al.
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
Blood,
April 1, 2007;
109(7):
2708 - 2717.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Callewaere, G. Banisadr, W. Rostene, and S. M. Parsadaniantz
Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation
J. Mol. Endocrinol.,
March 1, 2007;
38(3):
355 - 363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Forde, B. J. Tye, S. E. Newey, M. Roubelakis, J. Smythe, C. P. McGuckin, R. Pettengell, and S. M. Watt
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells
Blood,
March 1, 2007;
109(5):
1825 - 1833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. M. Pello, M. del Carmen Moreno-Ortiz, J. M. Rodriguez-Frade, L. Martinez-Munoz, D. Lucas, L. Gomez, P. Lucas, E. Samper, M. Aracil, C. Martinez-A, et al.
SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade
Blood,
December 1, 2006;
108(12):
3928 - 3937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Chunsong, H. Yuling, W. Li, X. Jie, Z. Gang, Z. Qiuping, G. Qingping, Z. Kejian, Q. Li, A. E. Chang, et al.
CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells
J. Immunol.,
November 15, 2006;
177(10):
6713 - 6722.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Luo, H. Pan, M. Mines, K. Watson, J. Zhang, and G.-H. Fan
CXCL12 Induces Tyrosine Phosphorylation of Cortactin, Which Plays a Role in CXC Chemokine Receptor 4-mediated Extracellular Signal-regulated Kinase Activation and Chemotaxis
J. Biol. Chem.,
October 6, 2006;
281(40):
30081 - 30093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Honczarenko, Y. Le, M. Swierkowski, I. Ghiran, A. M. Glodek, and L. E. Silberstein
Human Bone Marrow Stromal Cells Express a Distinct Set of Biologically Functional Chemokine Receptors
Stem Cells,
April 1, 2006;
24(4):
1030 - 1041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Foudi, P. Jarrier, Y. Zhang, M. Wittner, J.-F. Geay, Y. Lecluse, T. Nagasawa, W. Vainchenker, and F. Louache
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice
Blood,
March 15, 2006;
107(6):
2243 - 2251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Zhao, R. G. DiScipio, A. G. Wimmer, and I. U. Schraufstatter
Regulation of CXCR4-Mediated Nuclear Translocation of Extracellular Signal-Related Kinases 1 and 2
Mol. Pharmacol.,
January 1, 2006;
69(1):
66 - 75.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Dalakas, P. N. Newsome, D. J. Harrison, and J. N. Plevris
Hematopoietic stem cell trafficking in liver injury
FASEB J,
August 1, 2005;
19(10):
1225 - 1231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kucia, R. Reca, K. Miekus, J. Wanzeck, W. Wojakowski, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1-CXCR4 Axis
Stem Cells,
August 1, 2005;
23(7):
879 - 894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bendall, R. Baraz, J. Juarez, W. Shen, and K. F. Bradstock
Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1{alpha} in Acute Lymphoblastic Leukemia
Cancer Res.,
April 15, 2005;
65(8):
3290 - 3298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-B. Peng, V. Peek, Y. Zhai, D. C. Paul, Q. Lou, X. Xia, T. Eessalu, W. Kohn, and S. Tang
Akt Activation, but not Extracellular Signal-Regulated Kinase Activation, Is Required for SDF-1{alpha}/CXCR4-Mediated Migration of Epitheloid Carcinoma Cells
Mol. Cancer Res.,
April 1, 2005;
3(4):
227 - 236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Riol-Blanco, N. Sanchez-Sanchez, A. Torres, A. Tejedor, S. Narumiya, A. L. Corbi, P. Sanchez-Mateos, and J. L. Rodriguez-Fernandez
The Chemokine Receptor CCR7 Activates in Dendritic Cells Two Signaling Modules That Independently Regulate Chemotaxis and Migratory Speed
J. Immunol.,
April 1, 2005;
174(7):
4070 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Le, M. Honczarenko, A. M. Glodek, D. K. Ho, and L. E. Silberstein
CXC Chemokine Ligand 12-Induced Focal Adhesion Kinase Activation and Segregation into Membrane Domains Is Modulated by Regulator of G Protein Signaling 1 in Pro-B Cells
J. Immunol.,
March 1, 2005;
174(5):
2582 - 2590.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Ahr, M. Denizot, V. Robert-Hebmann, A. Brelot, and M. Biard-Piechaczyk
Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation
J. Biol. Chem.,
February 25, 2005;
280(8):
6692 - 6700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Okabe, S. Fukuda, Y.-J. Kim, M. Niki, L. M. Pelus, K. Ohyashiki, P. P. Pandolfi, and H. E. Broxmeyer
Stromal cell-derived factor-1{alpha}/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1
Blood,
January 15, 2005;
105(2):
474 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Weidt, B. Niggemann, W. Hatzmann, K. S. Zanker, and T. Dittmar
Differential Effects of Culture Conditions on the Migration Pattern of Stromal Cell-Derived Factor-Stimulated Hematopoietic Stem Cells
Stem Cells,
November 1, 2004;
22(6):
890 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, A. Foudi, J.-F. Geay, M. Berthebaud, D. Buet, P. Jarrier, A. Jalil, W. Vainchenker, and F. Louache
Intracellular Localization and Constitutive Endocytosis of CXCR4 in Human CD34+ Hematopoietic Progenitor Cells
Stem Cells,
November 1, 2004;
22(6):
1015 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Qiuping, X. Jei, J. Youxin, J. Wei, L. Chun, W. Jin, W. Qun, L. Yan, H. Chunsong, Y. Mingzhen, et al.
CC Chemokine Ligand 25 Enhances Resistance to Apoptosis in CD4+ T Cells from Patients with T-Cell Lineage Acute and Chronic Lymphocytic Leukemia by Means of Livin Activation
Cancer Res.,
October 15, 2004;
64(20):
7579 - 7587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Giebel, D. Corbeil, J. Beckmann, J. Hohn, D. Freund, K. Giesen, J. Fischer, G. Kogler, and P. Wernet
Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells
Blood,
October 15, 2004;
104(8):
2332 - 2338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Evans, R. Tonge, D. Blinco, A. Pierce, J. Shaw, Y. Lu, H. G. Hamzah, A. Gray, C. P. Downes, S. J. Gaskell, et al.
Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility
Blood,
May 15, 2004;
103(10):
3751 - 3759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Spiegel, O. Kollet, A. Peled, L. Abel, A. Nagler, B. Bielorai, G. Rechavi, J. Vormoor, and T. Lapidot
Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling
Blood,
April 15, 2004;
103(8):
2900 - 2907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Konakahara, K. Ohashi, K. Mizuno, K. Itoh, and T. Tsuji
CD29 integrin- and LIMK1/cofilin-mediated actin reorganization regulates the migration of haematopoietic progenitor cells underneath bone marrow stromal cells
Genes Cells,
April 1, 2004;
9(4):
345 - 358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zanin-Zhorov, R. Hershkoviz, I. Hecht, L. Cahalon, and O. Lider
Fibronectin-Associated Fas Ligand Rapidly Induces Opposing and Time-Dependent Effects on the Activation and Apoptosis of T Cells
J. Immunol.,
December 1, 2003;
171(11):
5882 - 5889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Jankowski, M. Kucia, M. Wysoczynski, R. Reca, D. Zhao, E. Trzyna, J. Trent, S. Peiper, M. Zembala, J. Ratajczak, et al.
Both Hepatocyte Growth Factor (HGF) and Stromal-Derived Factor-1 Regulate the Metastatic Behavior of Human Rhabdomyosarcoma Cells, But Only HGF Enhances Their Resistance to Radiochemotherapy
Cancer Res.,
November 15, 2003;
63(22):
7926 - 7935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sengupta, S. Caballero, R. N. Mames, J. M. Butler, E. W. Scott, and M. B. Grant
The Role of Adult Bone Marrow-Derived Stem Cells in Choroidal Neovascularization
Invest. Ophthalmol. Vis. Sci.,
November 1, 2003;
44(11):
4908 - 4913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-S. Bae, J. C. Park, R. He, R. D. Ye, J.-Y. Kwak, P.-G. Suh, and S. Ho Ryu
Differential Signaling of Formyl Peptide Receptor-Like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or Lipoxin A4 in Human Neutrophils
Mol. Pharmacol.,
September 1, 2003;
64(3):
721 - 730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Glodek, M. Honczarenko, Y. Le, J. J. Campbell, and L. E. Silberstein
Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis
J. Exp. Med.,
February 17, 2003;
197(4):
461 - 473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Roland, B. J. Murphy, B. Ahr, V. Robert-Hebmann, V. Delauzun, K. E. Nye, C. Devaux, and M. Biard-Piechaczyk
Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling
Blood,
January 15, 2003;
101(2):
399 - 406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Hwang, J. H. Hwang, H. K. Chung, D. W. Kim, E. S. Hwang, J. M. Suh, H. Kim, K.-H. You, O-Y. Kwon, H. K. Ro, et al.
CXC Chemokine Receptor 4 Expression and Function in Human Anaplastic Thyroid Cancer Cells
J. Clin. Endocrinol. Metab.,
January 1, 2003;
88(1):
408 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Hecht, L. Cahalon, R. Hershkoviz, A. Lahat, S. Franitza, and O. Lider
Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis
Int. Immunol.,
January 1, 2003;
15(1):
29 - 38.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. B. Adams, K. T. Chabner, R. B. Foxall, K. W. Weibrecht, N. P. Rodrigues, D. Dombkowski, R. Fallon, M. C. Poznansky, and D. T. Scadden
Heterologous cells cooperate to augment stem cell migration, homing, and engraftment
Blood,
January 1, 2003;
101(1):
45 - 51.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kijima, G. Maulik, P. C. Ma, E. V. Tibaldi, R. E. Turner, B. Rollins, M. Sattler, B. E. Johnson, and R. Salgia
Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells
Cancer Res.,
November 1, 2002;
62(21):
6304 - 6311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Libura, J. Drukala, M. Majka, O. Tomescu, J. M. Navenot, M. Kucia, L. Marquez, S. C. Peiper, F. G. Barr, A. Janowska-Wieczorek, et al.
CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
Blood,
September 18, 2002;
100(7):
2597 - 2606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ptasznik, E. Urbanowska, S. Chinta, M. A. Costa, B. A. Katz, M. A. Stanislaus, G. Demir, D. Linnekin, Z. K. Pan, and A. M. Gewirtz
Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells
J. Exp. Med.,
September 2, 2002;
196(5):
667 - 678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Dunussi-Joannopoulos, K. Zuberek, K. Runyon, R. G. Hawley, A. Wong, J. Erickson, S. Herrmann, and J. P. Leonard
Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses
Blood,
August 13, 2002;
100(5):
1551 - 1558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. F. Soriano, P. Hernanz-Falcon, J. M. Rodriguez-Frade, A. M. de Ana, R. Garzon, C. Carvalho-Pinto, A. J. Vila-Coro, A. Zaballos, D. Balomenos, C. Martinez-A., et al.
Functional Inactivation of CXC Chemokine Receptor 4-mediated Responses through SOCS3 Up-regulation
J. Exp. Med.,
August 5, 2002;
196(3):
311 - 321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. McLeod, A. H. Y. Li, R. L. Lee, A. E. Burgess, and M. R. Gold
The Rap GTPases Regulate B Cell Migration Toward the Chemokine Stromal Cell-Derived Factor-1 (CXCL12): Potential Role for Rap2 in Promoting B Cell Migration
J. Immunol.,
August 1, 2002;
169(3):
1365 - 1371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Fox, K. Ung, S. G. Tanlimco, and F. R. Jirik
Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1
J. Immunol.,
July 1, 2002;
169(1):
49 - 54.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Lee, A. Gotoh, H.-J. Kwon, M. You, L. Kohli, C. Mantel, S. Cooper, G. Hangoc, K. Miyazawa, K. Ohyashiki, et al.
Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines
Blood,
May 29, 2002;
99(12):
4307 - 4317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Inngjerdingen, K. M. Torgersen, and A. A. Maghazachi
Lck is required for stromal cell-derived factor 1alpha (CXCL12)-induced lymphoid cell chemotaxis
Blood,
May 29, 2002;
99(12):
4318 - 4325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Jiang, Y. Jia, and I. Cohen
Fibronectin- and protein kinase C-mediated activation of ERK/MAPK are essential for proplateletlike formation
Blood,
May 15, 2002;
99(10):
3579 - 3584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hideshima, D. Chauhan, T. Hayashi, K. Podar, M. Akiyama, D. Gupta, P. Richardson, N. Munshi, and K. C. Anderson
The Biological Sequelae of Stromal Cell-derived Factor-1{alpha} in Multiple Myeloma
Mol. Cancer Ther.,
May 1, 2002;
1(7):
539 - 544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ticchioni, C. Charvet, N. Noraz, L. Lamy, M. Steinberg, A. Bernard, and M. Deckert
Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration
Blood,
May 1, 2002;
99(9):
3111 - 3118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Li, J. Regezi, F. P. Ross, S. Blystone, D. Ilic, S. P. L. Leong, and D. M. Ramos
Integrin {alpha}v{beta}3 mediates K1735 murine melanoma cell motility in vivo and in vitro
J. Cell Sci.,
March 9, 2002;
114(14):
2665 - 2672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. Lataillade, D. Clay, P. Bourin, F. Herodin, C. Dupuy, C. Jasmin, and M.-C. Le Bousse-Kerdiles
Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism
Blood,
February 15, 2002;
99(4):
1117 - 1129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nishita, H. Aizawa, and K. Mizuno
Stromal Cell-Derived Factor 1{alpha} Activates LIM Kinase 1 and Induces Cofilin Phosphorylation for T-Cell Chemotaxis
Mol. Cell. Biol.,
February 1, 2002;
22(3):
774 - 783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Flaishon, F. Lantner, R. Hershkoviz, Y. Levo, and I. Shachar
Low Levels of IFN-gamma Down-regulate the Integrin-dependent Adhesion of B Cells by Activating a Pathway That Interferes with Cytoskeleton Rearrangement
J. Biol. Chem.,
December 7, 2001;
276(50):
46701 - 46706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Tanaka, A. Yoshida, T. Murakami, E. Baba, J. Lichtenfeld, T. Omori, T. Kimura, N. Tsurutani, N. Fujii, Z.-X. Wang, et al.
Unique Monoclonal Antibody Recognizing the Third Extracellular Loop of CXCR4 Induces Lymphocyte Agglutination and Enhances Human Immunodeficiency Virus Type 1-Mediated Syncytium Formation and Productive Infection
J. Virol.,
December 1, 2001;
75(23):
11534 - 11543.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Christopherson II and R. Hromas
Chemokine Regulation of Normal and Pathologic Immune Responses
Stem Cells,
September 1, 2001;
19(5):
388 - 396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kijowski, M. Baj-Krzyworzeka, M. Majka, R. Reca, L. A. Marquez, M. Christofidou-Solomidou, A. Janowska-Wieczorek, and M. Z. Ratajczak
The SDF-1-CXCR4 Axis Stimulates VEGF Secretion and Activates Integrins but does not Affect Proliferation and Survival in Lymphohematopoietic Cells
Stem Cells,
September 1, 2001;
19(5):
453 - 466.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Ottoson, J. T. Pribila, A. S. H. Chan, and Y. Shimizu
Cutting Edge: T Cell Migration Regulated by CXCR4 Chemokine Receptor Signaling to ZAP-70 Tyrosine Kinase
J. Immunol.,
August 15, 2001;
167(4):
1857 - 1861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-S. Youn, Y. J. Kim, C. Mantel, K.-Y. Yu, and H. E. Broxmeyer
Blocking of c-FLIPL-independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction
Blood,
August 15, 2001;
98(4):
925 - 933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-F. Zhang, J.-F. Wang, E. Matczak, J. Proper, and J. E. Groopman
Janus kinase 2 is involved in stromal cell-derived factor-1{alpha}-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells
Blood,
June 1, 2001;
97(11):
3342 - 3348.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bautz, C. Denzlinger, L. Kanz, and R. Mohle
Chemotaxis and transendothelial migration of CD34+ hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1
Blood,
June 1, 2001;
97(11):
3433 - 3440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shen, T. Cheng, I. Olszak, E. Garcia-Zepeda, Z. Lu, S. Herrmann, R. Fallon, A. D. Luster, and D. T. Scadden
CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells
J. Immunol.,
April 15, 2001;
166(8):
5027 - 5033.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. Cherla and R. K. Ganju
Stromal Cell-Derived Factor 1{{alpha}}-Induced Chemotaxis in T Cells Is Mediated by Nitric Oxide Signaling Pathways
J. Immunol.,
March 1, 2001;
166(5):
3067 - 3074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Colamussi, P. Secchiero, A. Gonelli, M. Marchisio, G. Zauli, and S. Capitani
Stromal derived factor-1{alpha} (SDF-1{alpha}) induces CD4+ T cell apoptosis via the functional up-regulation of the Fas (CD95)/Fas ligand (CD95L) pathway
J. Leukoc. Biol.,
February 1, 2001;
69(2):
263 - 270.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. D. Chernock, R. P. Cherla, and R. K. Ganju
SHP2 and cbl participate in {alpha}-chemokine receptor CXCR4-mediated signaling pathways
Blood,
February 1, 2001;
97(3):
608 - 615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Sanz-Rodriguez, A. Hidalgo, and J. Teixido
Chemokine stromal cell-derived factor-1{alpha} modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
Blood,
January 15, 2001;
97(2):
346 - 351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Haddad, J. L. Zugaza, F. Louache, N. Debili, C. Crouin, K. Schwarz, A. Fischer, W. Vainchenker, and J. Bertoglio
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis
Blood,
January 1, 2001;
97(1):
33 - 38.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Majka, A. Janowska-Wieczorek, J. Ratajczak, M. A. Kowalska, G. Vilaire, Z. K. Pan, M. Honczarenko, L. A. Marquez, M. Poncz, and M. Z. Ratajczak
Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis
Blood,
December 15, 2000;
96(13):
4142 - 4151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Watson, T. W. Harding, V. Golubovskaya, J. S. Morris, D. Hunter, X. Li, J. S. Haskill, and H. S. Earp
Inhibition of the Calcium-dependent Tyrosine Kinase (CADTK) Blocks Monocyte Spreading and Motility
J. Biol. Chem.,
January 26, 2001;
276(5):
3536 - 3542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wang, E. Guan, G. Roderiquez, V. Calvert, R. Alvarez, and M. A. Norcross
Role of Tyrosine Phosphorylation in Ligand-independent Sequestration of CXCR4 in Human Primary Monocytes-Macrophages
J. Biol. Chem.,
December 21, 2001;
276(52):
49236 - 49243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
