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Blood, Vol. 95 No. 8 (April 15), 2000:
pp. 2559-2568
Identification and characterization of a bipotent (erythroid and
megakaryocytic) cell precursor from the spleen of
phenylhydrazine-treated mice
Alessandro Maria Vannucchi,
Francesco Paoletti,
Silvia Linari,
Cristina Cellai,
Roberto Caporale,
Pierluigi Rossi Ferrini,
Massimo Sanchez,
Giovanni Migliaccio, and
Anna Rita Migliaccio
From the Division of Hematology, University of Florence and Azienda
Ospedaliera Careggi, Florence, Italy; and the Laboratory of Cell
Biology and Laboratory of Clinical Biochemistry, Istituto Superiore di
Sanità, Rome, Italy.
We have identified a cell population expressing erythroid (TER-119)
and megakaryocyte (4A5) markers in the bone marrow of normal mice. This
population is present at high frequency in the marrows and in the
spleens involved in the erythroid expansion that occurs in mice
recovering from phenylhydrazine (PHZ)-induced hemolytic anemia.
TER-119+/4A5+ cells were isolated from the
spleen of PHZ-treated animals and were found to be blast-like
benzidine-negative cells that generate erythroid and megakaryocytic
cells within 24-48 hours of culture in the presence of erythropoietin
(EPO) or thrombopoietin (TPO). TER-119+/4A5+ cells represent a late
bipotent erythroid and megakaryocytic cell precursors that may exert an
important role in the recovery from PHZ-induced anemia.
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