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Blood, Vol. 95 No. 8 (April 15), 2000:
pp. 2722-2724
BRIEF REPORT
Presence of clone-specific antigen receptor gene rearrangements
at birth indicates an in utero origin of diverse types of early
childhood acute lymphoblastic leukemia
Karin Fasching,
Simon Panzer,
Oskar A. Haas,
Rolf Marschalek,
Helmut Gadner, and
E.
Renate Panzer-Grümayer
From the Children's Cancer Research Institute (CCRI), St. Anna
Kinderspital, Vienna; the Clinic for Blood Group Serology, University
of Vienna, Vienna, Austria; and the Chair of Genetics, University of
Erlangen, Erlangen, Germany.
There is strong evidence that infant leukemias with a t(4;11)
translocation originate in utero. To test whether other subtypes of
childhood leukemias are also initiated during fetal life, we used
clone-specific genetic markers for the analysis of neonatal blood spots
from 5 children aged 6 months to 4 years 8 months at diagnosis of
pro-B, common acute lymphoblastic leukemia (ALL), and T-ALL. In all
children, the clonotypic antigen receptor gene rearrangements were
already present at birth. The estimated amount of clonotypic cells was
in the range of 10 to 100 cells per blood spot. In 2 infants with a
t(4;11) positive ALL, we detected similar amounts of the fusion gene
sequences compared with the clonal antigen receptor gene
rearrangements, suggesting the presence of both markers in the same
cells. Our data indicate that the first leukemogenic event of diverse
types of childhood ALL may already occur in utero.
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