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Blood, Vol. 95 No. 8 (April 15), 2000:
pp. 2725-2727
BRIEF REPORT
Expression of Ig- (CD79b) by chronic lymphocytic leukemia B
cells that lack immunoglobulin heavy-chain allelic exclusion
Laura Z. Rassenti and
Thomas J. Kipps
From the Division of Hematology/Oncology, Department of Medicine,
University of California-San Diego, La Jolla, CA.
Because immunoglobulin (Ig)- (CD79b) is required for
immunoglobulin allelic exclusion, we examined the CD79b expressed by four chronic lymphocytic leukemia (CLL) samples that expressed more
than one immunoglobulin heavy-chain allele and five samples that had
normal immunoglobulin heavy-chain allelic exclusion. All leukemia cell
samples stained poorly with monoclonal antibodies specific for
extracellular epitopes of CD79b. However, all samples expressed
functional CD79b genes, regardless of whether they did or did not
express more than one immunoglobulin heavy-chain allele. We identified
variant CD79b genes that had conservative base substitutions restricted
to regions encoding the extracellular immunoglobulin-like domain of
CD79b. However, these variants were not restricted to samples lacking
immunoglobulin heavy-chain allelic exclusion and most likely reflect
genetic polymorphism. Collectively, these data indicate that the
unusual expression of more than one immunoglobulin heavy allele by CLL
B cells is not associated with structural, nonconservative mutations in
the signal-transduction domains of CD79b.
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