|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 9 (May 1), 2000:
pp. 2754-2759
The primacy of the gastrointestinal tract as a target organ of
acute graft-versus-host disease: rationale for the use of cytokine
shields in allogeneic bone marrow transplantation
Geoffrey R. Hill and
James L. M. Ferrara
From the Mater Medical Research Institute, Brisbane, Australia, and
the Departments of Internal Medicine and Pediatrics, Division of
Hematology and Oncology, University of Michigan Cancer Center,
MI.
Acute graft-versus-host disease (GVHD), the major complication of
allogeneic bone marrow transplantation (BMT), limits the application of
this curative but toxic therapy. Studies of inflammatory pathways
involved in GVHD in animals have shown that the gastrointestinal (GI) tract plays a major role in the amplification of
systemic disease. Damage to the GI tract increases the translocation of inflammatory stimuli such as endotoxin, which promotes further inflammation and additional GI tract damage. The GI tract is therefore critical to the propagation of the "cytokine storm"
characteristic of acute GVHD. Experimental approaches to the prevention
of GVHD include reducing the damage to the GI tract by fortification of the GI mucosal barrier through novel "cytokine shields" such as IL-11 or keratinocyte growth factor. Such strategies have reduced GVHD
while preserving a graft-versus-leukemia effect in animal models, and
they now deserve formal testing in carefully designed clinical trials.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. M. Cao, L. C. Lazzeroni, S. Tsai, W. W. Pang, A. Kao, N. J. Camp, A. Thomas, and J. A. Shizuru
Identification of a Major Susceptibility Locus for Lethal Graft-versus-Host Disease in MHC-Matched Mice
J. Immunol.,
July 1, 2009;
183(1):
462 - 469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Markey, T. Banovic, R. D. Kuns, S. D. Olver, A. L. J. Don, N. C. Raffelt, Y. A. Wilson, L. J. Raggatt, A. R. Pettit, J. S. Bromberg, et al.
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
Blood,
May 28, 2009;
113(22):
5644 - 5649.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Kim, R. Romero, C. J. Kim, A. L. Tarca, S. Chhauy, C. LaJeunesse, D.-C. Lee, S. Draghici, F. Gotsch, J. P. Kusanovic, et al.
Villitis of Unknown Etiology Is Associated with a Distinct Pattern of Chemokine Up-Regulation in the Feto-Maternal and Placental Compartments: Implications for Conjoint Maternal Allograft Rejection and Maternal Anti-Fetal Graft-versus-Host Disease
J. Immunol.,
March 15, 2009;
182(6):
3919 - 3927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Haniffa, F. Ginhoux, X.-N. Wang, V. Bigley, M. Abel, I. Dimmick, S. Bullock, M. Grisotto, T. Booth, P. Taub, et al.
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation
J. Exp. Med.,
February 16, 2009;
206(2):
371 - 385.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hahn, P. L. McCarthy Jr, M.-J. Zhang, D. Wang, M. Arora, H. Frangoul, R. P. Gale, G. A. Hale, J. Horan, L. Isola, et al.
Risk Factors for Acute Graft-Versus-Host Disease After Human Leukocyte Antigen-Identical Sibling Transplants for Adults With Leukemia
J. Clin. Oncol.,
December 10, 2008;
26(35):
5728 - 5734.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Calcaterra, L. Sfondrini, A. Rossini, M. Sommariva, C. Rumio, S. Menard, and A. Balsari
Critical Role of TLR9 in Acute Graft-versus-Host Disease
J. Immunol.,
November 1, 2008;
181(9):
6132 - 6139.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Stelljes, S. Hermann, J. Albring, G. Kohler, M. Loffler, C. Franzius, C. Poremba, V. Schlosser, S. Volkmann, C. Opitz, et al.
Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography
Blood,
March 1, 2008;
111(5):
2909 - 2918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Kim, T. H. Terwey, J. L. Zakrzewski, D. Suh, A. A. Kochman, M. E. Chen, C. G. King, C. Borsotti, J. Grubin, O. M. Smith, et al.
Organ-derived dendritic cells have differential effects on alloreactive T cells
Blood,
March 1, 2008;
111(5):
2929 - 2940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Talarn, A. Urbano-Ispizua, R. Martino, J. A. Perez-Simon, M. Batlle, C. Herrera, M. Granell, A. Gaya, M. Torrebadell, F. Fernandez-Aviles, et al.
Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome
Haematologica,
December 1, 2007;
92(12):
1655 - 1663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yoshida, T. Hirano, G. Son, Y. Iimuro, T. Imado, T. Iwasaki, and J. Fujimoto
Allogeneic bone marrow transplantation for hepatocellular carcinoma: hepatocyte growth factor suppresses graft-vs.-host disease
Am J Physiol Gastrointest Liver Physiol,
December 1, 2007;
293(6):
G1114 - G1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Choi, G. C. Hildebrandt, K. M. Olkiewicz, D. A. Hanauer, M. N. Chaudhary, I. A. Silva, C. E. Rogers, D. T. Deurloo, J. M. Fisher, C. Liu, et al.
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
Blood,
November 1, 2007;
110(9):
3447 - 3455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. C. Baumeister, K. Holig, M. Bornhauser, M. Meurer, E. P. Rieber, and K. Schakel
G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity
Blood,
October 15, 2007;
110(8):
3078 - 3081.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Paulos, A. Kaiser, C. Wrzesinski, C. S. Hinrichs, L. Cassard, A. Boni, P. Muranski, L. Sanchez-Perez, D. C. Palmer, Z. Yu, et al.
Toll-like Receptors in Tumor Immunotherapy
Clin. Cancer Res.,
September 15, 2007;
13(18):
5280 - 5289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Burman, T. Banovic, R. D. Kuns, A. D. Clouston, A. C. Stanley, E. S. Morris, V. Rowe, H. Bofinger, R. Skoczylas, N. Raffelt, et al.
IFN{gamma} differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
Blood,
August 1, 2007;
110(3):
1064 - 1072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Fukui, M. Inaba, Y. Ueda, T. Miyake, N. Hosaka, A-H. Kwon, Y. Sakaguchi, M. Tsuda, M. Omae, Y. Kamiyama, et al.
Prevention of Graft-Versus-Host Disease by Intra-Bone Marrow Injection of Donor T Cells
Stem Cells,
June 1, 2007;
25(6):
1595 - 1601.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Hockenbery, S. Cruickshank, T. C. Rodell, T. Gooley, F. Schuening, S. Rowley, D. David, M. Brunvand, B. Berryman, S. Abhyankar, et al.
A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
Blood,
May 15, 2007;
109(10):
4557 - 4563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Blijlevens and S Sonis
Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis
Ann. Onc.,
May 1, 2007;
18(5):
817 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ueha, M. Murai, H. Yoneyama, M. Kitabatake, T. Imai, T. Shimaoka, S. Yonehara, S. Ishikawa, and K. Matsushima
Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects
J. Leukoc. Biol.,
January 1, 2007;
81(1):
176 - 185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Turner
Molecular Basis of Epithelial Barrier Regulation: From Basic Mechanisms to Clinical Application
Am. J. Pathol.,
December 1, 2006;
169(6):
1901 - 1909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. W. Blaser, N. R. Schwind, S. Karol, D. Chang, S. Shin, S. Roychowdhury, B. Becknell, A. K. Ferketich, D. F. Kusewitt, B. R. Blazar, et al.
Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity
Blood,
October 1, 2006;
108(7):
2463 - 2469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Rowe, T. Banovic, K. P. MacDonald, R. Kuns, A. L. Don, E. S. Morris, A. C. Burman, H. M. Bofinger, A. D. Clouston, and G. R. Hill
Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation
Blood,
October 1, 2006;
108(7):
2485 - 2492.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Morris, K. P. A. MacDonald, and G. R. Hill
Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?
Blood,
May 1, 2006;
107(9):
3430 - 3435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Carnevale-Schianca, A. Cignetti, A. Capaldi, K. Vitaggio, A. Vallario, A. Ricchiardi, E. Sperti, R. Ferraris, M. Gatti, G. Grignani, et al.
Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD
Blood,
May 1, 2006;
107(9):
3795 - 3803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Copelan
Hematopoietic stem-cell transplantation.
N. Engl. J. Med.,
April 27, 2006;
354(17):
1813 - 1826.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Banovic, K. P. A. MacDonald, E. S. Morris, V. Rowe, R. Kuns, A. Don, J. Kelly, S. Ledbetter, A. D. Clouston, and G. R. Hill
TGF-{beta} in allogeneic stem cell transplantation: friend or foe?
Blood,
September 15, 2005;
106(6):
2206 - 2214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Lipkin, P. Lenssen, and B. J. Dickson
Nutrition Issues in Hematopoietic Stem Cell Transplantation: State of the Art
Nutr Clin Pract,
August 1, 2005;
20(4):
423 - 439.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. M. Ferrara
GVHD: in vivo veritas
Blood,
August 1, 2005;
106(3):
772 - 773.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Beilhack, S. Schulz, J. Baker, G. F. Beilhack, C. B. Wieland, E. I. Herman, E. M. Baker, Y.-A. Cao, C. H. Contag, and R. S. Negrin
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets
Blood,
August 1, 2005;
106(3):
1113 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Hill
Host {gamma}{delta} T cells: an innate bridge to the epithelial targets of GVHD?
Blood,
July 15, 2005;
106(2):
393 - 394.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Maeda, P. Reddy, K. P. Lowler, C. Liu, D. K. Bishop, and J. L. M. Ferrara
Critical role of host {gamma}{delta} T cells in experimental acute graft-versus-host disease
Blood,
July 15, 2005;
106(2):
749 - 755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Wysocki, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody
Leukocyte migration and graft-versus-host disease
Blood,
June 1, 2005;
105(11):
4191 - 4199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Flierman, H. J. Witteveen, E. I. H. van der Voort, T. W. J. Huizinga, R. R. P. de Vries, W. E. Fibbe, R. E. M. Toes, and J. M. van Laar
Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation
Blood,
April 1, 2005;
105(7):
2991 - 2994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yada, N. Takamura, K. Inagaki-Ohara, M. K. O'Leary, C. Wasem, T. Brunner, D. R. Green, T. Lin, and M. J. Pinkoski
The Role of p53 and Fas in a Model of Acute Murine Graft-versus-Host Disease
J. Immunol.,
February 1, 2005;
174(3):
1291 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Hashimoto, S. Asakura, S. Miyake, T. Yamamura, L. Van Kaer, C. Liu, M. Tanimoto, and T. Teshima
Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T Cells
J. Immunol.,
January 1, 2005;
174(1):
551 - 556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-K. Min, Y. Maeda, K. Lowler, C. Liu, S. Clouthier, D. Lofthus, E. Weisiger, J. L. M. Ferrara, and P. Reddy
Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation
Blood,
November 15, 2004;
104(10):
3393 - 3399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Bendle, A. Holler, L.-K. Pang, S. Hsu, M. Krampera, E. Simpson, and H. J. Stauss
Induction of Unresponsiveness Limits Tumor Protection by Adoptively Transferred MDM2-Specific Cytotoxic T Lymphocytes
Cancer Res.,
November 1, 2004;
64(21):
8052 - 8056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Iwasaki
Recent Advances in the Treatment of Graft-Versus-Host Disease
Clin. Med. Res.,
November 1, 2004;
2(4):
243 - 252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Rettig, J. K. Ritchey, J. L. Prior, J. S. Haug, D. Piwnica-Worms, and J. F. DiPersio
Kinetics of In Vivo Elimination of Suicide Gene-Expressing T Cells Affects Engraftment, Graft-versus-Host Disease, and Graft-versus-Leukemia after Allogeneic Bone Marrow Transplantation
J. Immunol.,
September 15, 2004;
173(6):
3620 - 3630.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Holler, G. Rogler, H. Herfarth, J. Brenmoehl, P. J. Wild, J. Hahn, G. Eissner, J. Scholmerich, and R. Andreesen
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
Blood,
August 1, 2004;
104(3):
889 - 894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. A. Duffner, Y. Maeda, K. R. Cooke, P. Reddy, R. Ordemann, C. Liu, J. L. M. Ferrara, and T. Teshima
Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease
J. Immunol.,
June 15, 2004;
172(12):
7393 - 7398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Morris, K. P. A. MacDonald, V. Rowe, D. H. Johnson, T. Banovic, A. D. Clouston, and G. R. Hill
Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance
Blood,
May 1, 2004;
103(9):
3573 - 3581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Reddy, Y. Maeda, K. Hotary, C. Liu, L. L. Reznikov, C. A. Dinarello, and J. L. M. Ferrara
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
PNAS,
March 16, 2004;
101(11):
3921 - 3926.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Y. Mapara and M. Sykes
Tolerance and Cancer: Mechanisms of Tumor Evasion and Strategies for Breaking Tolerance
J. Clin. Oncol.,
March 15, 2004;
22(6):
1136 - 1151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. C. Hildebrandt, U. A. Duffner, K. M. Olkiewicz, L. A. Corrion, N. E. Willmarth, D. L. Williams, S. G. Clouthier, C. M. Hogaboam, P. R. Reddy, B. B. Moore, et al.
A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
Blood,
March 15, 2004;
103(6):
2417 - 2426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-W. Kim, Y.-J. Chung, T.-G. Kim, Y.-L. Kim, and I.-H. Oh
Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation
Blood,
March 1, 2004;
103(5):
1941 - 1948.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Holler
Early gastrointestinal GvHD: apoptosis but no donor repair?
Blood,
January 1, 2004;
103(1):
4 - 4.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Socie, J.-Y. Mary, M. Lemann, M. Daneshpouy, P. Guardiola, V. Meignin, L. Ades, H. Esperou, P. Ribaud, A. Devergie, et al.
Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression
Blood,
January 1, 2004;
103(1):
50 - 57.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Papadimitriou, C. B. Cangro, A. Lustberg, A. Khaled, J. Nogueira, A. Wiland, E. Ramos, D. K. Klassen, and C. B. Drachenberg
Histologic Features of Mycophenolate Mofetil-Related Colitis: A Graft-Versus-Host Disease-Like Pattern
International Journal of Surgical Pathology,
October 1, 2003;
11(4):
295 - 302.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Mielcarek, P. J. Martin, W. Leisenring, M. E. D. Flowers, D. G. Maloney, B. M. Sandmaier, M. B. Maris, and R. Storb
Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation
Blood,
July 15, 2003;
102(2):
756 - 762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ichiba, T. Teshima, R. Kuick, D. E. Misek, C. Liu, Y. Takada, Y. Maeda, P. Reddy, D. L. Williams, S. M. Hanash, et al.
Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays
Blood,
July 15, 2003;
102(2):
763 - 771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Reddy, T. Teshima, G. Hildebrandt, D. L. Williams, C. Liu, K. R. Cooke, and J. L.M. Ferrara
Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects
Blood,
April 1, 2003;
101(7):
2877 - 2885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. A. MacDonald, V. Rowe, C. Filippich, R. Thomas, A. D. Clouston, J. K. Welply, D. N. J. Hart, J. L. M. Ferrara, and G. R. Hill
Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation
Blood,
March 1, 2003;
101(5):
2033 - 2042.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ratzinger, J. L. Reagan, G. Heller, K. J. Busam, and J. W. Young
Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation
Blood,
February 15, 2003;
101(4):
1422 - 1429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. O'Brien, N. M.A. Blijlevens, T. H. Mahfouz, and E. J. Anaissie
Infections in Patients with Hematological Cancer: Recent Developments
Hematology,
January 1, 2003;
2003(1):
438 - 472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Cooke, K. Olkiewicz, N. Erickson, and J. L.M. Ferrara
The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease
Innate Immunity,
December 1, 2002;
8(6):
441 - 448.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Akpek, J. K. Boitnott, L. A. Lee, J. P. Hallick, M. Torbenson, D. A. Jacobsohn, S. Arai, V. Anders, and G. B. Vogelsang
Hepatitic variant of graft-versus-host disease after donor lymphocyte infusion
Blood,
December 1, 2002;
100(12):
3903 - 3907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Hoffmann, J. Ermann, M. Edinger, C. G. Fathman, and S. Strober
Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation
J. Exp. Med.,
August 5, 2002;
196(3):
389 - 399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Daneshpouy, G. Socie, M. Lemann, J. Rivet, E. Gluckman, and A. Janin
Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease
Blood,
April 15, 2002;
99(8):
3033 - 3040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Reddy, T. Teshima, M. Kukuruga, R. Ordemann, C. Liu, K. Lowler, and J. L.M. Ferrara
Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis
J. Exp. Med.,
November 12, 2001;
194(10):
1433 - 1440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Cooke, G. R. Hill, A. Gerbitz, L. Kobzik, T. R. Martin, J. M. Crawford, J. P. Brewer, and J. L. M. Ferrara
Hyporesponsiveness of Donor Cells to Lipopolysaccharide Stimulation Reduces the Severity of Experimental Idiopathic Pneumonia Syndrome: Potential Role for a Gut-Lung Axis of Inflammation
J. Immunol.,
December 1, 2000;
165(11):
6612 - 6619.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Reddy
Granulocyte colony-stimulating factor mobilization alters dendritic cell cytokine production and initiates T helper 2 polarization prior to host alloantigen presentation
Blood,
October 1, 2000;
96(7):
2635 - 2635.
[Full Text]
[PDF]
|
|
|
|
|
