|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 95 No. 9 (May 1), 2000:
pp. 2869-2874
Role of IL-16 in delayed-type hypersensitivity reaction
Takayuki Yoshimoto,
Chrong-Reen Wang,
Toshihiko Yoneto,
Akio Matsuzawa,
William W. Cruikshank, and
Hideo Nariuchi
From the Department of Allergology and Animal Laboratory Research
Center, Institute of Medical Science, The University of Tokyo, Tokyo,
Japan; Intractable Disease Research Center, Tokyo Medical University,
Tokyo, Japan; and The Pulmonary Center, Boston University School of
Medicine, Boston, MA.
Interleukin (IL)-16 is a chemoattractant cytokine for
CD4+ leukocytes. Because delayed-type hypersensitivity
(DTH) reaction is mediated by T helper 1 (Th1) cells and
CD4+ T cells can be chemoattracted by IL-16, we have
investigated the involvement of IL-16 in the DTH reaction.
Immunohistochemical analysis revealed the IL-16 expression in
infiltrating cells and epithelial cells in the DTH footpads. The IL-16
expression was also detected intracellularly in the infiltrating cells.
In addition, markedly increased production of IL-16 was detected in the
DTH footpad extracts, but not in the control footpad extracts, by an
enzyme-linked immunosorbent assay and also by Western blot analysis.
The DTH footpad extracts exhibited a strong chemoattractant activity
toward splenic T cells, which was significantly inhibited by the
inclusion of neutralizing monoclonal antibody (mAb) against IL-16 in
the migration assay. Furthermore, treatment of sensitized mice in vivo
with the anti-IL-16 neutralizing mAb significantly suppressed the
footpad swelling induced by an antigen challenge, together with
decreased infiltration of leukocytes including not only
CD4+ T cells but also CD8+ T cells and
macrophages into the DTH footpads. Decreased production of
macrophage inflammatory protein 1 was also observed in the DTH
footpad extracts by the mAb treatment. These results suggest that IL-16
plays an important role in the recruitment of leukocytes presumably including antigen-specific Th1 cells, which secrete cytokines and
chemokines mediating the following hypersensitivity reaction after
activation by the interaction with Langerhans cells carrying the
antigenfor the elicitation of DTH response.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. McFadden, R. Morgan, S. Rahangdale, D. Green, H. Yamasaki, D. Center, and W. Cruikshank
Preferential Migration of T Regulatory Cells Induced by IL-16
J. Immunol.,
November 15, 2007;
179(10):
6439 - 6445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nambu, S. Nakae, and Y. Iwakura
IL-1{beta}, but not IL-1{alpha}, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
Int. Immunol.,
May 1, 2006;
18(5):
701 - 712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Rahangdale, R. Morgan, C. Heijens, T. C. Ryan, H. Yamasaki, E. Bentley, E. Sullivan, D. M. Center, and W. W. Cruikshank
Chemokine Receptor CXCR3 Desensitization by IL-16/CD4 Signaling Is Dependent on CCR5 and Intact Membrane Cholesterol
J. Immunol.,
February 15, 2006;
176(4):
2337 - 2345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Pritchard, S. Tsui, N. Horst, W. W. Cruikshank, and T. J. Smith
Synovial Fibroblasts from Patients with Rheumatoid Arthritis, Like Fibroblasts from Graves' Disease, Express High Levels of IL-16 When Treated with Igs against Insulin-Like Growth Factor-1 Receptor
J. Immunol.,
September 1, 2004;
173(5):
3564 - 3569.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M.B. Roman, P. I. Lobo, R. P. Taylor, D. A. Goodkin, J. LaBrecque, K. L. Powers, and W. K. Bolton
Prospective Study of the Immune Effects of Normalizing the Hemoglobin Concentration in Hemodialysis Patients Who Receive Recombinant Human Erythropoietin
J. Am. Soc. Nephrol.,
May 1, 2004;
15(5):
1339 - 1346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Reich, A. Heine, S. Hugo, V. Blaschke, P. Middel, A. Kaser, H. Tilg, S. Blaschke, C. Gutgesell, and C. Neumann
Engagement of the Fc{epsilon}RI Stimulates the Production of IL-16 in Langerhans Cell-Like Dendritic Cells
J. Immunol.,
December 1, 2001;
167(11):
6321 - 6329.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
