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Blood, Vol. 96 No. 1 (July 1), 2000:
pp. 139-144
Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion
of primitive hematopoietic cells into stromal cell layers
Nobuaki Yanai,
Naoko Matsui,
Tadashi Furusawa,
Tadashi Okubo, and
Masuo Obinata
From the Department of Cell Biology, Institute of Development, Aging
and Cancer, Tohoku University, Sendai, Japan.
A new primitive hematopoietic cell line (THS119), exhibiting
Lin /Sca-1+/c-Kit+ a surface
phenotype, grew and survived underneath stromal cells (TBR59). The
ability of the THS119 cells to invade these stromal cell layers was
dependent on the inclusion of serum in the culture medium. This was
apparently due to a requirement for lipids contained in serum. Their
invasion of the stromal cell layers in serum-free cultures could be
triggered by addition of sphingosine-1-phosphate (S1P) or
lysophosphatidic acid (LPA) and was dependent on both Rho- and
Ras-signaling pathways. Between the 2 possible receptors of S1P and
LPA, edg-1 and edg-2, expression of edg-2 only
was found to be correlated with immaturity and/or invasive activity of
the primitive hematopoietic cells. These results suggest the importance
of specific lipids and their specific receptors on the invasive
activity of primitive hematopoietic cells in the hematopoietic microenvironment.
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