SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Salcedo, R. Articles by Murphy, W. J. Search for Related Content PubMed PubMed Citation Articles by Salcedo, R. Articles by Murphy, W. J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 96 No. 1 (July 1), 2000: pp. 34-40 Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression Rosalba Salcedo, Maria Lourdes Ponce, Howard A. Young, Ken Wasserman, Jerrold M. Ward, Hynda K. Kleinman, Joost J. Oppenheim, and William J. Murphy From the Laboratory of Molecular Immunoregulation, Laboratory of Experimental Immunology, Division of Basic Sciences; Intramural Research Support Program, SAIC; Veterinary and Tumor Pathology Section, Office of Laboratory Animal Resources, Frederick Cancer Research and Development Center, Frederick, MD; and Cell Biology Section, National Institute of Dental and Craniofacial Research, Bethesda, MD. Although several CXC chemokines have been shown to induce angiogenesis and play roles in tumor growth, to date, no member of the CC chemokine family has been reported to play a direct role in angiogenesis. Here we report that the CC chemokine, monocyte chemotactic protein 1 (MCP-1), induced chemotaxis of human endothelial cells at nanomolar concentrations. This chemotactic response was inhibited by a monoclonal antibody to MCP-1. MCP-1 also induced the formation of blood vessels in vivo as assessed by the chick chorioallantoic membrane and the matrigel plug assays. As expected, the angiogenic response induced by MCP-1 was accompanied by an inflammatory response. With the use of a rat aortic sprouting assay in the absence of leukocytic infiltrates, we ruled out the possibility that the angiogenic effect of MCP-1 depended on leukocyte products. Moreover, the direct effect of MCP-1 on angiogenesis was consistent with the expression of CCR2, the receptor for MCP-1, on endothelial cells. Assessment of supernatant from a human breast carcinoma cell line demonstrated the production of MCP-1. Treatment of immunodeficient mice bearing human breast carcinoma cells with a neutralizing antibody to MCP-1 resulted in significant increases in survival and inhibition of the growth of lung micrometastases. Taken together, our data indicate that MCP-1 can act as a direct mediator of angiogenesis. As a chemokine that is abundantly produced by some tumors, it can also directly contribute to tumor progression. Therefore, therapy employing antagonists of MCP-1 in combination with other inhibitors of angiogenesis may achieve more comprehensive inhibition of tumor growth. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. Zhang, M. Rojas, B. Lilly, N.-T. Tsai, T. Lemtalsi, G. I. Liou, R. W. Caldwell, and R. B. Caldwell NAD(P)H Oxidase-Dependent Regulation of CCL2 Production during Retinal Inflammation Invest. Ophthalmol. Vis. Sci., June 1, 2009; 50(6): 3033 - 3040. [Abstract] [Full Text] [PDF] D.-E. Lee, S. Kehlenbrink, H. Lee, M. Hawkins, and J. S. Yudkin Getting the message across: mechanisms of physiological cross talk by adipose tissue Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1210 - E1229. [Abstract] [Full Text] [PDF] X. Li, R. Loberg, J. Liao, C. Ying, L. A. Snyder, K. J. Pienta, and L. K. McCauley A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone Cancer Res., February 15, 2009; 69(4): 1685 - 1692. [Abstract] [Full Text] [PDF] E. C. Keeley, B. Mehrad, and R. M. Strieter Chemokines as Mediators of Neovascularization Arterioscler. Thromb. Vasc. Biol., November 1, 2008; 28(11): 1928 - 1936. [Abstract] [Full Text] [PDF] E Lozano, M Segarra, A Garcia-Martinez, J Hernandez-Rodriguez, and M C Cid Imatinib mesylate inhibits in vitro and ex vivo biological responses related to vascular occlusion in giant cell arteritis Ann Rheum Dis, November 1, 2008; 67(11): 1581 - 1588. [Abstract] [Full Text] [PDF] G. T. Stathopoulos, I. Psallidas, A. Moustaki, C. Moschos, A. Kollintza, S. Karabela, I. Porfyridis, S. Vassiliou, M. Karatza, Z. Zhou, et al. A Central Role for Tumor-derived Monocyte Chemoattractant Protein-1 in Malignant Pleural Effusion J Natl Cancer Inst, October 15, 2008; 100(20): 1464 - 1476. [Abstract] [Full Text] [PDF] M. H. Davies, A. J. Stempel, and M. R. Powers MCP-1 Deficiency Delays Regression of Pathologic Retinal Neovascularization in a Model of Ischemic Retinopathy Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 4195 - 4202. [Abstract] [Full Text] [PDF] B. J. Capoccia, A. D. Gregory, and D. C. Link Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion J. Leukoc. Biol., September 1, 2008; 84(3): 760 - 768. [Abstract] [Full Text] [PDF] L. Yahiaoui, D. Gvozdic, G. Danialou, M. Mack, and B. J. Petrof CC family chemokines directly regulate myoblast responses to skeletal muscle injury J. Physiol., August 15, 2008; 586(16): 3991 - 4004. [Abstract] [Full Text] [PDF] F.-Y. Wu, Z.-L. Ou, L.-Y. Feng, J.-M. Luo, L.-P. Wang, Z.-Z. Shen, and Z.-M. Shao Chemokine Decoy Receptor D6 Plays a Negative Role in Human Breast Cancer Mol. Cancer Res., August 1, 2008; 6(8): 1276 - 1288. [Abstract] [Full Text] [PDF] H. Morimoto, M. Hirose, M. Takahashi, M. Kawaguchi, H. Ise, P. E. Kolattukudy, M. Yamada, and U. Ikeda MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species Cardiovasc Res, June 1, 2008; 78(3): 554 - 562. [Abstract] [Full Text] [PDF] J. Niu, A. Azfer, O. Zhelyabovska, S. Fatma, and P. E. Kolattukudy Monocyte Chemotactic Protein (MCP)-1 Promotes Angiogenesis via a Novel Transcription Factor, MCP-1-induced Protein (MCPIP) J. Biol. Chem., May 23, 2008; 283(21): 14542 - 14551. [Abstract] [Full Text] [PDF] Y.-Y. Tsai, J.-M. Lin, L. Wan, H.-J. Lin, Y. Tsai, C.-C. Lee, C.-H. Tsai, F.-J. Tsai, and S.-H. Tseng Interleukin Gene Polymorphisms in Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 693 - 698. [Abstract] [Full Text] [PDF] M. Itaya, E. Sakurai, M. Nozaki, K. Yamada, S. Yamasaki, K. Asai, and Y. Ogura Upregulation of VEGF in Murine Retina via Monocyte Recruitment after Retinal Scatter Laser Photocoagulation Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5677 - 5683. [Abstract] [Full Text] [PDF] T. Kanayasu-Toyoda, A. Ishii-Watabe, T. Suzuki, T. Oshizawa, and T. Yamaguchi A New Role of Thrombopoietin Enhancing ex Vivo Expansion of Endothelial Precursor Cells Derived from AC133-positive Cells J. Biol. Chem., November 16, 2007; 282(46): 33507 - 33514. [Abstract] [Full Text] [PDF] J. Y. Kim, Y. Wu, and C. M. Smas Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes Physiol Genomics, October 19, 2007; 31(2): 328 - 342. [Abstract] [Full Text] [PDF] C. E. Brown, R. P. Vishwanath, B. Aguilar, R. Starr, J. Najbauer, K. S. Aboody, and M. C. Jensen Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T Cells J. Immunol., September 1, 2007; 179(5): 3332 - 3341. [Abstract] [Full Text] [PDF] R.M. Dwyer, S.M. Potter-Beirne, K.A. Harrington, A.J. Lowery, E. Hennessy, J.M. Murphy, F.P. Barry, T. O'Brien, and M.J. Kerin Monocyte Chemotactic Protein-1 Secreted by Primary Breast Tumors Stimulates Migration of Mesenchymal Stem Cells Clin. Cancer Res., September 1, 2007; 13(17): 5020 - 5027. [Abstract] [Full Text] [PDF] C. P. Baran, J. M. Opalek, S. McMaken, C. A. Newland, J. M. O'Brien Jr., M. G. Hunter, B. D. Bringardner, M. M. Monick, D. R. Brigstock, P. C. Stromberg, et al. Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 78 - 89. [Abstract] [Full Text] [PDF] P. E. Pellett Totally tubular: virally induced endothelial tube formation Blood, April 1, 2007; 109(7): 2669 - 2670. [Full Text] [PDF] E. Caselli, S. Fiorentini, C. Amici, D. Di Luca, A. Caruso, and M. G. Santoro Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-{kappa}B pathway Blood, April 1, 2007; 109(7): 2718 - 2726. [Abstract] [Full Text] [PDF] N. G. Frangogiannis, O. Dewald, Y. Xia, G. Ren, S. Haudek, T. Leucker, D. Kraemer, G. Taffet, B. J. Rollins, and M. L. Entman Critical Role of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 in the Pathogenesis of Ischemic Cardiomyopathy Circulation, February 6, 2007; 115(5): 584 - 592. [Abstract] [Full Text] [PDF] V. Contreras-Shannon, O. Ochoa, S. M. Reyes-Reyna, D. Sun, J. E. Michalek, W. A. Kuziel, L. M. McManus, and P. K. Shireman Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury Am J Physiol Cell Physiol, February 1, 2007; 292(2): C953 - C967. [Abstract] [Full Text] [PDF] T Ellingsen, N Hornung, B K Moller, J H Poulsen, and K Stengaard-Pedersen Differential effect of methotrexate on the increased CCR2 density on circulating CD4 T lymphocytes and monocytes in active chronic rheumatoid arthritis, with a down regulation only on monocytes in responders Ann Rheum Dis, February 1, 2007; 66(2): 151 - 157. [Abstract] [Full Text] [PDF] J. Ma, Q. Wang, T. Fei, J.-D. J. Han, and Y.-G. Chen MCP-1 mediates TGF-{beta}-induced angiogenesis by stimulating vascular smooth muscle cell migration Blood, February 1, 2007; 109(3): 987 - 994. [Abstract] [Full Text] [PDF] X. Li, E. Calvo, M. Cool, P. Chrobak, D. G. Kay, and P. Jolicoeur Overexpression of Notch1 Ectodomain in Myeloid Cells Induces Vascular Malformations through a Paracrine Pathway Am. J. Pathol., January 1, 2007; 170(1): 399 - 415. [Abstract] [Full Text] [PDF] M. C. Cid, M. P. Hoffman, J. Hernandez-Rodriguez, M. Segarra, M. Elkin, M. Sanchez, C. Vilardell, A. Garcia-Martinez, M. Pla-Campo, J. M. Grau, et al. Association between increased CCL2 (MCP-1) expression in lesions and persistence of disease activity in giant-cell arteritis Rheumatology, November 1, 2006; 45(11): 1356 - 1363. [Abstract] [Full Text] [PDF] H. Morimoto, M. Takahashi, A. Izawa, H. Ise, M. Hongo, P. E. Kolattukudy, and U. Ikeda Cardiac Overexpression of Monocyte Chemoattractant Protein-1 in Transgenic Mice Prevents Cardiac Dysfunction and Remodeling After Myocardial Infarction Circ. Res., October 13, 2006; 99(8): 891 - 899. [Abstract] [Full Text] [PDF] A. M. McCord, S. I. Resto-Ruiz, and B. E. Anderson Autocrine Role for Interleukin-8 in Bartonella henselae-Induced Angiogenesis Infect. Immun., September 1, 2006; 74(9): 5185 - 5190. [Abstract] [Full Text] [PDF] S. M. Stamatovic, R. F. Keep, M. Mostarica-Stojkovic, and A. V. Andjelkovic CCL2 Regulates Angiogenesis via Activation of Ets-1 Transcription Factor J. Immunol., August 15, 2006; 177(4): 2651 - 2661. [Abstract] [Full Text] [PDF] J.-S. Nam, M.-J. Kang, A. M. Suchar, T. Shimamura, E. A. Kohn, A. M. Michalowska, V. C. Jordan, S. Hirohashi, and L. M. Wakefield Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells. Cancer Res., July 15, 2006; 66(14): 7176 - 7184. [Abstract] [Full Text] [PDF] E. E. Brown, D. Fallin, I. Ruczinski, A. Hutchinson, B. Staats, F. Vitale, C. Lauria, D. Serraino, G. Rezza, G. Mbisa, et al. Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 926 - 934. [Abstract] [Full Text] [PDF] H. Sell, D. Dietze-Schroeder, U. Kaiser, and J. Eckel Monocyte Chemotactic Protein-1 Is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle Endocrinology, May 1, 2006; 147(5): 2458 - 2467. [Abstract] [Full Text] [PDF] L. Zentilin, S. Tafuro, S. Zacchigna, N. Arsic, L. Pattarini, M. Sinigaglia, and M. Giacca Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels Blood, May 1, 2006; 107(9): 3546 - 3554. [Abstract] [Full Text] [PDF] L. Waeckel, J. Bignon, J.-M. Liu, D. Markovits, T. G. Ebrahimian, J. Vilar, B. Mees, O. Blanc-Brude, V. Barateau, S. Le ricousse-Roussanne, et al. Tetrapeptide AcSDKP Induces Postischemic Neovascularization Through Monocyte Chemoattractant Protein-1 Signaling Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 773 - 779. [Abstract] [Full Text] [PDF] H. Mu, R. Ohashi, S. Yan, H. Chai, H. Yang, P. Lin, Q. Yao, and C. Chen Adipokine resistin promotes in vitro angiogenesis of human endothelial cells Cardiovasc Res, April 1, 2006; 70(1): 146 - 157. [Abstract] [Full Text] [PDF] Z. A. Dehqanzada, C. E. Storrer, M. T. Hueman, R. J. Foley, K. A. Harris, Y. H. Jama, T.-C. Kao, C. D. Shriver, S. Ponniah, and G. E. Peoples Correlations between Serum Monocyte Chemotactic Protein-1 Levels, Clinical Prognostic Factors, and HER-2/neu Vaccine-Related Immunity in Breast Cancer Patients Clin. Cancer Res., January 15, 2006; 12(2): 478 - 486. [Abstract] [Full Text] [PDF] E. Ryschich, P. Lizdenis, C. Ittrich, A. Benner, S. Stahl, A. Hamann, J. Schmidt, P. Knolle, B. Arnold, G. J. Hammerling, et al. Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma Cancer Res., January 1, 2006; 66(1): 198 - 211. [Abstract] [Full Text] [PDF] T. Nakayama, N. Mutsuga, L. Yao, and G. Tosato Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells J. Leukoc. Biol., January 1, 2006; 79(1): 95 - 104. [Abstract] [Full Text] [PDF] E. Zudaire, A. Martinez, M. Garayoa, R. Pio, G. Kaur, M. R. Woolhiser, D. D. Metcalfe, W. A. Hook, R. P. Siraganian, T. A. Guise, et al. Adrenomedullin Is a Cross-Talk Molecule that Regulates Tumor and Mast Cell Function during Human Carcinogenesis Am. J. Pathol., January 1, 2006; 168(1): 280 - 291. [Abstract] [Full Text] [PDF] H. Spring, T. Schuler, B. Arnold, G. J. Hammerling, and R. Ganss Chemokines direct endothelial progenitors into tumor neovessels PNAS, December 13, 2005; 102(50): 18111 - 18116. [Abstract] [Full Text] [PDF] T. Kuroda, Y. Kitadai, S. Tanaka, X. Yang, N. Mukaida, M. Yoshihara, and K. Chayama Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment Clin. Cancer Res., November 1, 2005; 11(21): 7629 - 7636. [Abstract] [Full Text] [PDF] J. P. Cullen, S. Sayeed, Y. Jin, N. G. Theodorakis, J. V. Sitzmann, P. A. Cahill, and E. M. Redmond Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1669 - H1675. [Abstract] [Full Text] [PDF] S. Li, F. Takeuchi, J.-a. Wang, C. Fuller, G. Pacheco-Rodriguez, J. Moss, and T. N. Darling MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development J. Exp. Med., September 6, 2005; 202(5): 617 - 624. [Abstract] [Full Text] [PDF] T. Sakamoto, T. Ishibashi, N. Sakamoto, K. Sugimoto, K. Egashira, H. Ohkawara, K. Nagata, K. Yokoyama, M. Kamioka, T. Ichiki, et al. Endogenous NO Blockade Enhances Tissue Factor Expression via Increased Ca2+ Influx Through MCP-1 in Endothelial Cells by Monocyte Adhesion Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 2005 - 2011. [Abstract] [Full Text] [PDF] M. Zareie, A. S. De Vriese, L. H. P. Hekking, P. M. ter Wee, C. G. Schalkwijk, B. A. J. Driesprong, I. L. Schadee-Eestermans, R. H. J. Beelen, N. Lameire, and J. van den Born Immunopathological changes in a uraemic rat model for peritoneal dialysis Nephrol. Dial. Transplant., July 1, 2005; 20(7): 1350 - 1361. [Abstract] [Full Text] [PDF] E. J. Harvey and D. P. Ramji Interferon-{gamma} and atherosclerosis: Pro- or anti-atherogenic? Cardiovasc Res, July 1, 2005; 67(1): 11 - 20. [Abstract] [Full Text] [PDF] O. Dewald, P. Zymek, K. Winkelmann, A. Koerting, G. Ren, T. Abou-Khamis, L. H. Michael, B. J. Rollins, M. L. Entman, and N. G. Frangogiannis CCL2/Monocyte Chemoattractant Protein-1 Regulates Inflammatory Responses Critical to Healing Myocardial Infarcts Circ. Res., April 29, 2005; 96(8): 881 - 889. [Abstract] [Full Text] [PDF] H. W. van Deventer, W. O'Connor Jr., W. J. Brickey, R. M. Aris, J. P.Y. Ting, and J. S. Serody C-C Chemokine Receptor 5 on Stromal Cells Promotes Pulmonary Metastasis Cancer Res., April 15, 2005; 65(8): 3374 - 3379. [Abstract] [Full Text] [PDF] S. K. Manna and G. T. Ramesh Interleukin-8 Induces Nuclear Transcription Factor-{kappa}B through a TRAF6-dependent Pathway J. Biol. Chem., February 25, 2005; 280(8): 7010 - 7021. [Abstract] [Full Text] [PDF] Y. Cao, A. Hong, H. Schulten, and M. J. Post Update on therapeutic neovascularization Cardiovasc Res, February 15, 2005; 65(3): 639 - 648. [Abstract] [Full Text] [PDF] K. H. Hong, J. Ryu, and K. H. Han Monocyte chemoattractant protein-1-induced angiogenesis is mediated by vascular endothelial growth factor-A Blood, February 15, 2005; 105(4): 1405 - 1407. [Abstract] [Full Text] [PDF] B. G. Galvez, L. Genis, S. Matias-Roman, S. A. Oblander, K. Tryggvason, S. S. Apte, and A. G. Arroyo Membrane Type 1-Matrix Metalloproteinase Is Regulated by Chemokines Monocyte-Chemoattractant Protein-1/CCL2 and Interleukin-8/CXCL8 in Endothelial Cells during Angiogenesis J. Biol. Chem., January 14, 2005; 280(2): 1292 - 1298. [Abstract] [Full Text] [PDF] C. L. Speyer, H. Gao, N. J. Rancilio, T. A. Neff, G. B. Huffnagle, J. V. Sarma, and P. A. Ward Novel Chemokine Responsiveness and Mobilization of Neutrophils during Sepsis Am. J. Pathol., December 1, 2004; 165(6): 2187 - 2196. [Abstract] [Full Text] [PDF] M. Ishibashi, K. Egashira, Q. Zhao, K.-i. Hiasa, K. Ohtani, Y. Ihara, I. F. Charo, S. Kura, T. Tsuzuki, A. Takeshita, et al. Bone Marrow-Derived Monocyte Chemoattractant Protein-1 Receptor CCR2 Is Critical in Angiotensin II-Induced Acceleration of Atherosclerosis and Aneurysm Formation in Hypercholesterolemic Mice Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): e174 - e178. [Abstract] [Full Text] [PDF] D. Piwnica, P. Touraine, I. Struman, S. Tabruyn, G. Bolbach, C. Clapp, J. A. Martial, P. A. Kelly, and V. Goffin Cathepsin D Processes Human Prolactin into Multiple 16K-Like N-Terminal Fragments: Study of Their Antiangiogenic Properties and Physiological Relevance Mol. Endocrinol., October 1, 2004; 18(10): 2522 - 2542. [Abstract] [Full Text] [PDF] G. M. Gordillo, D. Onat, M. Stockinger, S. Roy, M. Atalay, F. M. Beck, and C. K. Sen A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation Am J Physiol Cell Physiol, October 1, 2004; 287(4): C866 - C873. [Abstract] [Full Text] [PDF] J J Haringman, J Ludikhuize, and P P Tak Chemokines in joint disease: the key to inflammation? Ann Rheum Dis, October 1, 2004; 63(10): 1186 - 1194. [Abstract] [Full Text] [PDF] E. Khmelewski, A. Becker, T. Meinertz, and W. D. Ito Tissue Resident Cells Play a Dominant Role in Arteriogenesis and Concomitant Macrophage Accumulation Circ. Res., September 17, 2004; 95(6): e56 - e64. [Abstract] [Full Text] [PDF] J. F. Grosso, L. M. Herbert, J. L. Owen, and D. M. Lopez MUC1/sec-Expressing Tumors Are Rejected In Vivo by a T Cell-Dependent Mechanism and Secrete High Levels of CCL2 J. Immunol., August 1, 2004; 173(3): 1721 - 1730. [Abstract] [Full Text] [PDF] G. Spinetti, M. Wang, R. Monticone, J. Zhang, D. Zhao, and E. G. Lakatta Rat Aortic MCP-1 and Its Receptor CCR2 Increase With Age and Alter Vascular Smooth Muscle Cell Function Arterioscler. Thromb. Vasc. Biol., August 1, 2004; 24(8): 1397 - 1402. [Abstract] [Full Text] [PDF] Z.-M. Bian, S. G. Elner, A. Yoshida, and V. M. Elner Differential Involvement of Phosphoinositide 3-Kinase/Akt in Human RPE MCP-1 and IL-8 Expression Invest. Ophthalmol. Vis. Sci., June 1, 2004; 45(6): 1887 - 1896. [Abstract] [Full Text] [PDF] M. Heil, T. Ziegelhoeffer, S. Wagner, B. Fernandez, A. Helisch, S. Martin, S. Tribulova, W. A. Kuziel, G. Bachmann, and W. Schaper Collateral Artery Growth (Arteriogenesis) After Experimental Arterial Occlusion Is Impaired in Mice Lacking CC-Chemokine Receptor-2 Circ. Res., March 19, 2004; 94(5): 671 - 677. [Abstract] [Full Text] [PDF] K. Johrer, K. Janke, J. Krugmann, M. Fiegl, and R. Greil Transendothelial Migration of Myeloma Cells Is Increased by Tumor Necrosis Factor (TNF)-{alpha} via TNF Receptor 2 and Autocrine Up-Regulation of MCP-1 Clin. Cancer Res., March 15, 2004; 10(6): 1901 - 1910. [Abstract] [Full Text] [PDF] G. C. Hildebrandt, U. A. Duffner, K. M. Olkiewicz, L. A. Corrion, N. E. Willmarth, D. L. Williams, S. G. Clouthier, C. M. Hogaboam, P. R. Reddy, B. B. Moore, et al. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation Blood, March 15, 2004; 103(6): 2417 - 2426. [Abstract] [Full Text] [PDF] J. Oostendorp, M. N. Hylkema, M. Luinge, M. Geerlings, H. Meurs, W. Timens, J. Zaagsma, D. S. Postma, H. W. Boddeke, and K. Biber Localization and Enhanced mRNA Expression of the Orphan Chemokine Receptor L-CCR in the Lung in a Murine Model of Ovalbumin-induced Airway Inflammation J. Histochem. Cytochem., March 1, 2004; 52(3): 401 - 410. [Abstract] [Full Text] [PDF] A. Babiak, A.-M. Schumm, C. Wangler, M. Loukas, J. Wu, S. Dombrowski, C. Matuschek, J. Kotzerke, C. Dehio, and J. Waltenberger Coordinated activation of VEGFR-1 and VEGFR-2 is a potent arteriogenic stimulus leading to enhancement of regional perfusion Cardiovasc Res, March 1, 2004; 61(4): 789 - 795. [Abstract] [Full Text] [PDF] M. Strasly, G. Doronzo, P. Capello, D. Valdembri, M. Arese, S. Mitola, P. Moore, G. Alessandri, M. Giovarelli, and F. Bussolino CCL16 activates an angiogenic program in vascular endothelial cells Blood, January 1, 2004; 103(1): 40 - 49. [Abstract] [Full Text] [PDF] S. M. Stamatovic, R. F. Keep, S. L. Kunkel, and A. V. Andjelkovic Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase J. Cell Sci., November 15, 2003; 116(22): 4615 - 4628. [Abstract] [Full Text] [PDF] S. Fujiyama, K. Amano, K. Uehira, M. Yoshida, Y. Nishiwaki, Y. Nozawa, D. Jin, S. Takai, M. Miyazaki, K. Egashira, et al. Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1-Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells Circ. Res., November 14, 2003; 93(10): 980 - 989. [Abstract] [Full Text] [PDF] C. A.U. Heilmann, T. Attmann, A. Thiem, E. Haffner, F. Beyersdorf, and G. Lutter Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia Eur. J. Cardiothorac. Surg., November 1, 2003; 24(5): 785 - 793. [Abstract] [Full Text] [PDF] P. Monti, B. E. Leone, F. Marchesi, G. Balzano, A. Zerbi, F. Scaltrini, C. Pasquali, G. Calori, F. Pessi, C. Sperti, et al. The CC Chemokine MCP-1/CCL2 in Pancreatic Cancer Progression: Regulation of Expression and Potential Mechanisms of Antimalignant Activity Cancer Res., November 1, 2003; 63(21): 7451 - 7461. [Abstract] [Full Text] [PDF] M. Yamada, S. Kim, K. Egashira, M. Takeya, T. Ikeda, O. Mimura, and H. Iwao Molecular Mechanism and Role of Endothelial Monocyte Chemoattractant Protein-1 Induction by Vascular Endothelial Growth Factor Arterioscler. Thromb. Vasc. Biol., November 1, 2003; 23(11): 1996 - 2001. [Abstract] [Full Text] [PDF] R. Salcedo, X. Zhang, H. A. Young, N. Michael, K. Wasserman, W.-H. Ma, M. Martins-Green, W. J. Murphy, and J. J. Oppenheim Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells Blood, September 15, 2003; 102(6): 1966 - 1977. [Abstract] [Full Text] [PDF] N. G. Frangogiannis, L. H. Mendoza, G. Ren, S. Akrivakis, P. L. Jackson, L. H. Michael, C. W. Smith, and M. L. Entman MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H483 - H492. [Abstract] [Full Text] [PDF] P. Sartipy and D. J. Loskutoff Monocyte chemoattractant protein 1 in obesity and insulin resistance PNAS, June 10, 2003; 100(12): 7265 - 7270. [Abstract] [Full Text] [PDF] J. Hernandez-Rodriguez, M. Segarra, C. Vilardell, M. Sanchez, A. Garcia-Martinez, M.-J. Esteban, J. M. Grau, A. Urbano-Marquez, D. Colomer, H. K. Kleinman, et al. Elevated Production of Interleukin-6 Is Associated With a Lower Incidence of Disease-Related Ischemic Events in Patients With Giant-Cell Arteritis: Angiogenic Activity of Interleukin-6 as a Potential Protective Mechanism Circulation, May 20, 2003; 107(19): 2428 - 2434. [Abstract] [Full Text] [PDF] P. G. Lloyd, B. M. Prior, H. T. Yang, and R. L. Terjung Angiogenic growth factor expression in rat skeletal muscle in response to exercise training Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1668 - H1678. [Abstract] [Full Text] [PDF] G. T. Higgins, J. H. Wang, P. Dockery, P. E. Cleary, and H. P. Redmond Induction of Angiogenic Cytokine Expression in Cultured RPE by Ingestion of Oxidized Photoreceptor Outer Segments Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1775 - 1782. [Abstract] [Full Text] [PDF] P. Lu, Y. Nakamoto, Y. Nemoto-Sasaki, C. Fujii, H. Wang, M. Hashii, Y. Ohmoto, S. Kaneko, K. Kobayashi, and N. Mukaida Potential Interaction between CCR1 and Its Ligand, CCL3, Induced by Endogenously Produced Interleukin-1 in Human Hepatomas Am. J. Pathol., April 1, 2003; 162(4): 1249 - 1258. [Abstract] [Full Text] [PDF] A. Li, S. Dubey, M. L. Varney, B. J. Dave, and R. K. Singh IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis J. Immunol., March 15, 2003; 170(6): 3369 - 3376. [Abstract] [Full Text] [PDF] J. Guo, M. Van Eck, J. Twisk, N. Maeda, G. M. Benson, P. H.E. Groot, and T. J.C. Van Berkel Transplantation of Monocyte CC-Chemokine Receptor 2-Deficient Bone Marrow Into ApoE3-Leiden Mice Inhibits Atherogenesis Arterioscler. Thromb. Vasc. Biol., March 1, 2003; 23(3): 447 - 453. [Abstract] [Full Text] [PDF] S. Yoshida, A. Yoshida, T. Ishibashi, S. G. Elner, and V. M. Elner Role of MCP-1 and MIP-1{alpha} in retinal neovascularization during postischemic inflammation in a mouse model of retinal neovascularization J. Leukoc. Biol., January 1, 2003; 73(1): 137 - 144. [Abstract] [Full Text] [PDF] C. Lubeseder-Martellato, E. Guenzi, A. Jorg, K. Topolt, E. Naschberger, E. Kremmer, C. Zietz, E. Tschachler, P. Hutzler, M. Schwemmle, et al. Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases Am. J. Pathol., November 1, 2002; 161(5): 1749 - 1759. [Abstract] [Full Text] [PDF] M. C. Cid, J. Hernandez-Rodriguez, M.-J. Esteban, M. Cebrian, Y. S. Gho, C. Font, A. Urbano-Marquez, J. M. Grau, and H. K. Kleinman Tissue and Serum Angiogenic Activity Is Associated With Low Prevalence of Ischemic Complications in Patients With Giant-Cell Arteritis Circulation, September 24, 2002; 106(13): 1664 - 1671. [Abstract] [Full Text] [PDF] R. Salcedo, M. Martins-Green, B. Gertz, J. J. Oppenheim, and W. J. Murphy Combined Administration of Antibodies to Human Interleukin 8 and Epidermal Growth Factor Receptor Results in Increased Antimetastatic Effects on Human Breast Carcinoma Xenografts Clin. Cancer Res., August 1, 2002; 8(8): 2655 - 2665. [Abstract] [Full Text] [PDF] W. I. de Boer Cytokines and Therapy in COPD* : A Promising Combination? Chest, May 1, 2002; 121(5_suppl): 209S - 218S. [Abstract] [Full Text] [PDF] E. Azenshtein, G. Luboshits, S. Shina, E. Neumark, D. Shahbazian, M. Weil, N. Wigler, I. Keydar, and A. Ben-Baruch The CC Chemokine RANTES in Breast Carcinoma Progression: Regulation of Expression and Potential Mechanisms of Promalignant Activity Cancer Res., February 1, 2002; 62(4): 1093 - 1102. [Abstract] [Full Text] [PDF] D. H. Townson, C. L. O'Connor, and J. K. Pru Expression of Monocyte Chemoattractant Protein-1 and Distribution of Immune Cell Populations in the Bovine Corpus Luteum Throughout the Estrous Cycle Biol Reprod, February 1, 2002; 66(2): 361 - 366. [Abstract] [Full Text] [PDF] K. A. Dzenko, A. V. Andjelkovic, W. A. Kuziel, and J. S. Pachter The Chemokine Receptor CCR2 Mediates the Binding and Internalization of Monocyte Chemoattractant Protein-1 along Brain Microvessels J. Neurosci., December 1, 2001; 21(23): 9214 - 9223. [Abstract] [Full Text] [PDF] T. O. Nossuli, N. G. Frangogiannis, P. Knuefermann, V. Lakshminarayanan, O. Dewald, A. J. Evans, J. Peschon, D. L. Mann, L. H. Michael, and M. L. Entman Brief murine myocardial I/R induces chemokines in a TNF-alpha -independent manner: role of oxygen radicals Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2549 - H2558. [Abstract] [Full Text] [PDF] Y. Yu, J. Varughese, L. F. Brown, J. B. Mulliken, and J. Bischoff Increased Tie2 Expression, Enhanced Response to Angiopoietin-1, and Dysregulated Angiopoietin-2 Expression in Hemangioma-Derived Endothelial Cells Am. J. Pathol., December 1, 2001; 159(6): 2271 - 2280. [Abstract] [Full Text] [PDF] R. T. Palframan, S. Jung, G. Cheng, W. Weninger, Y. Luo, M. Dorf, D. R. Littman, B. J. Rollins, H. Zweerink, A. Rot, et al. Inflammatory Chemokine Transport and Presentation in HEV: A Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues J. Exp. Med., November 5, 2001; 194(9): 1361 - 1374. [Abstract] [Full Text] [PDF] R. Salcedo, H. A. Young, M. L. Ponce, J. M. Ward, H. K. Kleinman, W. J. Murphy, and J. J. Oppenheim Eotaxin (CCL11) Induces In Vivo Angiogenic Responses by Human CCR3+ Endothelial Cells J. Immunol., June 15, 2001; 166(12): 7571 - 7578. [Abstract] [Full Text] [PDF] M. Nesbit, H. Schaider, T. H. Miller, and M. Herlyn Low-Level Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontumorigenic Melanoma Cells J. Immunol., June 1, 2001; 166(11): 6483 - 6490. [Abstract] [Full Text] [PDF] R. Gillitzer and M. Goebeler Chemokines in cutaneous wound healing J. Leukoc. Biol., April 1, 2001; 69(4): 513 - 521. [Abstract] [Full Text] G. Bernardini, G. Spinetti, D. Ribatti, G. Camarda, L. Morbidelli, M. Ziche, A. Santoni, M. C. Capogrossi, and M. Napolitano I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo Blood, December 15, 2000; 96(13): 4039 - 4045. [Abstract] [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020