|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 96 No. 1 (July 1), 2000:
pp. 71-75
Fludarabine and cyclophosphamide with filgrastim support in
patients with previously untreated indolent lymphoid malignancies
Ian W. Flinn,
John C. Byrd,
Candis Morrison,
Janet Jamison,
Louis F. Diehl,
Timothy Murphy,
Steve Piantadosi,
Eric Seifter,
Richard F. Ambinder,
Georgia Vogelsang, and
Michael R. Grever
From Johns Hopkins Oncology Center, Baltimore, MD, and Walter Reed
Army Medical Center, Washington, DC.
To evaluate the response rate and potential toxicities, a phase II
trial was conducted of fludarabine and cyclophosphamide with filgrastim
support in patients with previously untreated low-grade and select
intermediate-grade lymphoid malignancies. Symptomatic patients with
preserved end organ function received cyclophosphamide 600 mg/m2 intravenous (iv) day 1 and fludarabine 20 mg/m2 iv days1 through 5, followed by filgrastim 5 µg/kg
subcutaneous starting approximately day 8. Treatment was repeated every
28 days until maximum response or a maximum of 6 cycles. Sixty
patients, median age 53.5 years, were enrolled. Thirty-seven
patients with non-Hodgkin lymphoma (NHL) were stage IV and
6 were stage III. Eleven of 17 patients with chronic lymphocytic
leukemia (CLL) were Rai intermediate risk and 6 were high risk. The
overall complete response (CR) rate was 51% and the partial response
(PR) rate was 41%. Of patients with CLL, 47% achieved a CR and the
remaining 53% achieved a PR. Of patients with follicular lymphoma,
60% achieved CR and 32% achieved a PR. Although the toxicity of this
regimen was mainly hematologic, significant nonhematologic
toxicities, including infections, were seen. Twenty-four
patients subsequently received an autologous or allogeneic stem
cell transplant. Engraftment was rapid, and there were no
noticeable procedure toxicities in the immediate posttransplant period
attributable to the fludarabine and cyclophosphamide regimen.
Fludarabine, cyclophosphamide, and filgrastim make up a highly
active and well-tolerated regimen in CLL and NHL.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. M. Tsimberidou, W. G. Wierda, W. Plunkett, R. Kurzrock, S. O'Brien, S. Wen, A. Ferrajoli, F. Ravandi-Kashani, G. Garcia-Manero, Z. Estrov, et al.
Phase I-II Study of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab Combination Therapy in Patients With Richter's Syndrome or Fludarabine-Refractory Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
January 10, 2008;
26(2):
196 - 203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Bosch, A. Ferrer, N. Villamor, M. Gonzalez, J. Briones, E. Gonzalez-Barca, E. Abella, S. Gardella, L. Escoda, E. Perez-Ceballos, et al.
Fludarabine, Cyclophosphamide, and Mitoxantrone as Initial Therapy of Chronic Lymphocytic Leukemia: High Response Rate and Disease Eradication
Clin. Cancer Res.,
January 1, 2008;
14(1):
155 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nimmanapalli, M.-A. Lyu, M. Du, M. J. Keating, M. G. Rosenblum, and V. Gandhi
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells
Blood,
March 15, 2007;
109(6):
2557 - 2564.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. W. Flinn, D. S. Neuberg, M. R. Grever, G. W. Dewald, J. M. Bennett, E. M. Paietta, M. A. Hussein, F. R. Appelbaum, R. A. Larson, D. F. Moore Jr, et al.
Phase III Trial of Fludarabine Plus Cyclophosphamide Compared With Fludarabine for Patients With Previously Untreated Chronic Lymphocytic Leukemia: US Intergroup Trial E2997
J. Clin. Oncol.,
March 1, 2007;
25(7):
793 - 798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Morrison
Management of Infectious Complications in Patients with Chronic Lymphocytic Leukemia
Hematology,
January 1, 2007;
2007(1):
332 - 338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Robak, J. Z. Blonski, J. Gora-Tybor, K. Jamroziak, J. Dwilewicz-Trojaczek, A. Tomaszewska, L. Konopka, B. Ceglarek, A. Dmoszynska, M. Kowal, et al.
Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2)
Blood,
July 15, 2006;
108(2):
473 - 479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hagenbeek, H. Eghbali, S. Monfardini, U. Vitolo, P. J. Hoskin, C. de Wolf-Peeters, K. MacLennan, E. Staab-Renner, J. Kalmus, A. Schott, et al.
Phase III Intergroup Study of Fludarabine Phosphate Compared With Cyclophosphamide, Vincristine, and Prednisone Chemotherapy in Newly Diagnosed Patients With Stage III and IV Low-Grade Malignant Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
April 1, 2006;
24(10):
1590 - 1596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Lamanna, M. Kalaycio, P. Maslak, J. G. Jurcic, M. Heaney, R. Brentjens, A. D. Zelenetz, D. Horgan, A. Gencarelli, K. S. Panageas, et al.
Pentostatin, Cyclophosphamide, and Rituximab Is an Active, Well-Tolerated Regimen for Patients With Previously Treated Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
April 1, 2006;
24(10):
1575 - 1581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. F. Eichhorst, R. Busch, G. Hopfinger, R. Pasold, M. Hensel, C. Steinbrecher, S. Siehl, U. Jager, M. Bergmann, S. Stilgenbauer, et al.
Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
Blood,
February 1, 2006;
107(3):
885 - 891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. G. Wierda
Current and Investigational Therapies for Patients with CLL
Hematology,
January 1, 2006;
2006(1):
285 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. L. Kasamon, I. W. Flinn, M. R. Grever, L. F. Diehl, E. Garrett-Mayer, S. N. Goodman, M. S. Lucas, and J. C. Byrd
Phase I Study of Low-Dose Interleukin-2, Fludarabine, and Cyclophosphamide for Previously Untreated Indolent Lymphoma and Chronic Lymphocytic Leukemia
Clin. Cancer Res.,
December 1, 2005;
11(23):
8413 - 8417.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Elter, P. Borchmann, H. Schulz, M. Reiser, S. Trelle, R. Schnell, M. Jensen, P. Staib, T. Schinkothe, H. Stutzer, et al.
Fludarabine in Combination With Alemtuzumab Is Effective and Feasible in Patients With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia: Results of a Phase II Trial
J. Clin. Oncol.,
October 1, 2005;
23(28):
7024 - 7031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Z. Pavletic, I. F. Khouri, M. Haagenson, R. J. King, P. J. Bierman, M. R. Bishop, M. Carston, S. Giralt, A. Molina, E. A. Copelan, et al.
Unrelated Donor Marrow Transplantation for B-Cell Chronic Lymphocytic Leukemia After Using Myeloablative Conditioning: Results From the Center for International Blood and Marrow Transplant Research
J. Clin. Oncol.,
August 20, 2005;
23(24):
5788 - 5794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Lin, M. R. Grever, and J. C. Byrd
Changing the Way We Think About Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
June 20, 2005;
23(18):
4009 - 4012.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Keating, S. O'Brien, M. Albitar, S. Lerner, W. Plunkett, F. Giles, M. Andreeff, J. Cortes, S. Faderl, D. Thomas, et al.
Early Results of a Chemoimmunotherapy Regimen of Fludarabine, Cyclophosphamide, and Rituximab As Initial Therapy for Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
June 20, 2005;
23(18):
4079 - 4088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Balakrishnan, C. M. Stellrecht, D. Genini, M. Ayres, W. G. Wierda, M. J. Keating, L. M. Leoni, and V. Gandhi
Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP
Blood,
June 1, 2005;
105(11):
4455 - 4462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Foussard, P. Colombat, H. Maisonneuve, C. Berthou, R. Gressin, M.-C. Rousselet, P. Rachieru, B. Pignon, B. Mahe, C. Ghandour, et al.
Long-term follow-up of a randomized trial of fludarabine-mitoxantrone, compared with cyclophosphamide, doxorubicin, vindesine, prednisone (CHVP), as first-line treatment of elderly patients with advanced, low-grade non-Hodgkin's lymphoma before the era of monoclonal antibodies
Ann. Onc.,
March 1, 2005;
16(3):
466 - 472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.S. Czuczman, A. Koryzna, A. Mohr, C. Stewart, K. Donohue, L. Blumenson, Z.P. Bernstein, P. McCarthy, A. Alam, F. Hernandez-Ilizaliturri, et al.
Rituximab in Combination With Fludarabine Chemotherapy in Low-Grade or Follicular Lymphoma
J. Clin. Oncol.,
February 1, 2005;
23(4):
694 - 704.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hallek and On Behalf Of The German CLL Study Group
Chronic Lymphocytic Leukemia (CLL): First-Line Treatment
Hematology,
January 1, 2005;
2005(1):
285 - 291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Solal-Celigny, P. Roy, P. Colombat, J. White, J. O. Armitage, R. Arranz-Saez, W. Y. Au, M. Bellei, P. Brice, D. Caballero, et al.
Follicular Lymphoma International Prognostic Index
Blood,
September 1, 2004;
104(5):
1258 - 1265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Zinzani, A. Pulsoni, A. Perrotti, S. Soverini, F. Zaja, A. De Renzo, S. Storti, V. M. Lauta, L. Guardigni, P. Gentilini, et al.
Fludarabine Plus Mitoxantrone With and Without Rituximab Versus CHOP With and Without Rituximab As Front-Line Treatment for Patients With Follicular Lymphoma
J. Clin. Oncol.,
July 1, 2004;
22(13):
2654 - 2661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Mone, P. Huang, H. Pelicano, C. M. Cheney, J. M. Green, J. Y. Tso, A. J. Johnson, S. Jefferson, T. S. Lin, and J. C. Byrd
Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells
Blood,
March 1, 2004;
103(5):
1846 - 1854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Byrd, S. Stilgenbauer, and I. W. Flinn
Chronic Lymphocytic Leukemia
Hematology,
January 1, 2004;
2004(1):
163 - 183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Baldini, M. Brugiatelli, S. Luminari, M. Lombardo, F. Merli, S. Sacchi, P. Gobbi, M. Liberati, L. Cavanna, M. Colombi, et al.
Treatment of Indolent B-Cell Nonfollicular Lymphomas: Final Results of the LL01 Randomized Trial of the Gruppo Italiano per lo Studio dei Linfomi
J. Clin. Oncol.,
April 15, 2003;
21(8):
1459 - 1465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Weiss, P. G. Maslak, J. G. Jurcic, D. A. Scheinberg, T. B. Aliff, N. Lamanna, S. R. Frankel, S. E. Kossman, and D. Horgan
Pentostatin and Cyclophosphamide: An Effective New Regimen in Previously Treated Patients With Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
April 1, 2003;
21(7):
1278 - 1284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Keating, N. Chiorazzi, B. Messmer, R. N. Damle, S. L. Allen, K. R. Rai, M. Ferrarini, and T. J. Kipps
Biology and Treatment of Chronic Lymphocytic Leukemia
Hematology,
January 1, 2003;
2003(1):
153 - 175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Byrd, B. L. Peterson, V. A. Morrison, K. Park, R. Jacobson, E. Hoke, J. W. Vardiman, K. Rai, C. A. Schiffer, and R. A. Larson
Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)
Blood,
January 1, 2003;
101(1):
6 - 14.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Tsimberidou, P. McLaughlin, A. Younes, M. A. Rodriguez, F. B. Hagemeister, A. Sarris, J. Romaguera, M. Hess, T. L. Smith, Y. Yang, et al.
Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) regimen in patients with stage IV indolent lymphoma
Blood,
December 15, 2002;
100(13):
4351 - 4357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Schulz, S. K. Klein, U. Rehwald, M. Reiser, A. Hinke, W.-U. Knauf, W.-E. Aulitzky, M. Hensel, M. Herold, D. Huhn, et al.
Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
Blood,
October 16, 2002;
100(9):
3115 - 3120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Morrison, K. R. Rai, B. L. Peterson, J. E. Kolitz, L. Elias, F. R. Appelbaum, J. D. Hines, L. Shepherd, R. A. Larson, and C. A. Schiffer
Therapy-Related Myeloid Leukemias Are Observed in Patients With Chronic Lymphocytic Leukemia After Treatment With Fludarabine and Chlorambucil: Results of an Intergroup Study, Cancer and Leukemia Group B 9011
J. Clin. Oncol.,
September 15, 2002;
20(18):
3878 - 3884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. E. Kay, T. J. Hamblin, D. F. Jelinek, G. W. Dewald, J. C. Byrd, S. Farag, M. Lucas, and T. Lin
Chronic Lymphocytic Leukemia
Hematology,
January 1, 2002;
2002(1):
193 - 213.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. S. Copur, P. Ledakis, J. Muhvic, M. Erman, I. Celik, G. Tekuzman, M. Marchetti, G. Barosi, L. N. Liberato, S. J. Proctor, et al.
Fludarabine for Chronic Lymphocytic Leukemia
N. Engl. J. Med.,
April 12, 2001;
344(15):
1166 - 1168.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. O'Brien, H. M. Kantarjian, J. Cortes, M. Beran, C. A. Koller, F. J. Giles, S. Lerner, and M. Keating
Results of the Fludarabine and Cyclophosphamide Combination Regimen in Chronic Lymphocytic Leukemia
J. Clin. Oncol.,
March 1, 2001;
19(5):
1414 - 1420.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
