|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 December 2000, Vol. 96, No. 12, pp. 3866-3871
IMMUNOBIOLOGY
T-lymphocyte maturation abnormalities in uninfected newborns and
children with vertical exposure to HIV
Mario Clerici,
Marina Saresella,
Fulvia Colombo,
Sabrina Fossati,
Natascia Sala,
Dorella Bricalli,
Maria Luisa Villa,
Pasquale Ferrante,
Len Dally, and
Alessandra Vigano'
From the Cattedra di Immunologia, Università di
Milano, DISP LITA Vialba, Milano; Laboratorio di Biologia, Fondazione
Don C. Gnocchi, IRCCS, Via Capecelatro, Milano; Cattedra di Pediatria
IV, Università di Milano, Ospedale Luigi Sacco, Milano; and
Laboratorio di Virologia, Istituto Superiore di Sanità, Roma,
Italy.
Cell-mediated immunity and T-lymphocyte maturation are impaired in
HIV-infected children. These abnormalities would be detected in
HIV-uninfected offspring of HIV women (seroreverters [SR]) if HIV or
its soluble proteins could cross the placental barrier. Immunophenotypic analyses were performed in 20 healthy HIV-uninfected newborns of HIV-infected mothers (SR), and in 14 healthy newborns of
HIV-negative women (UC). The same analyses were performed in 3 groups
of older children: SR (n = 41); UC (n = 15); and HIV-infected children (n = 25). Antigen-specific cells were evaluated with ELISpot
and fluorimetric analyses; IL-7 serum concentration was measured by
enzyme-linked immunosorbent assay (ELISA). Results showed that in SR
newborns: (1) the CD4/CD8 ratio was reduced, (2) CD4+ and
CD8+ naive T-cell percentages were decreased, (3)
percentage of activated CD8+ T cells was increased, and (4)
percentages of CD3+/4 /8 (DN)
and DN/25/44+ were augmented. These
abnormalities were partially retained in older SR children.
CD4+ and CD8+ HIV-specific cells were detected
in a portion of newborn SRs but not in older SRs. Serum IL-7 was
augmented both in newborn and older SRs. Cell-mediated immunity and
T-cell maturation are altered even in HIV-uninfected newborns of
HIV-infected mothers; these abnormalities persist over time. The
biologic significance of these observations and potential subsequent
clinical events should be investigated in larger cohorts of seroreverters.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. B. Schramm, S. Meddows-Taylor, G. E. Gray, L. Kuhn, and C. T. Tiemessen
Low Maternal Viral Loads and Reduced Granulocyte-Macrophage Colony-Stimulating Factor Levels Characterize Exposed, Uninfected Infants Who Develop Protective Human Immunodeficiency Virus Type 1-Specific Responses
Clin. Vaccine Immunol.,
April 1, 2007;
14(4):
348 - 354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Rouet, A. Inwoley, D. K. Ekouevi, I. Viho, R. Becquet, C. Sakarovitch, L. Bequet, B. Tonwe-Gold, M.-L. Chaix, V. Leroy, et al.
CD4 Percentages and Total Lymphocyte Counts as Early Surrogate Markers for Pediatric HIV-1 Infection in Resource-Limited Settings
J Trop Pediatr,
October 1, 2006;
52(5):
346 - 354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Shalekoff, G. E. Gray, and C. T. Tiemessen
Age-Related Changes in Expression of CXCR4 and CCR5 on Peripheral Blood Leukocytes from Uninfected Infants Born to Human Immunodeficiency Virus Type 1-Infected Mothers
Clin. Vaccine Immunol.,
January 1, 2004;
11(1):
229 - 234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Steffens, E. Z. Managlia, A. Landay, and L. Al-Harthi
Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1
Blood,
May 1, 2002;
99(9):
3310 - 3318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Nielsen, D. L. Jeppesen, L. Kolte, D. R. Clark, T. U. Sorensen, A.-M. Dreves, A. K. Ersboll, L. P. Ryder, N. H. Valerius, and J. O. Nielsen
Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts
Blood,
July 15, 2001;
98(2):
398 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
