|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 December 2000, Vol. 96, No. 12, pp. 3872-3879
IMMUNOBIOLOGY
Thymomas alter the T-cell subset composition in the blood: a
potential mechanism for thymoma-associated autoimmune disease
Viola Hoffacker,
Anja Schultz,
James J. Tiesinga,
Ralf Gold,
Berthold Schalke,
Wilfred Nix,
Reinhard Kiefer,
Hans Konrad Müller-Hermelink, and
Alexander Marx
From the Institute of Pathology, University of
Würzburg, Würzburg, Germany; New York University
Medical Center, Tisch Hospital, New York, NY; Department of
Neurology, University of Würzburg, Würzburg, Germany;
Institute of Neurology, University of Regensburg, Regensburg,
Germany; Department of Neurology, University of Mainz, Mainz,
Germany; Department of Neurology, University of Münster,
Münster, Germany.
Thymomas are the only tumors that are proven to generate mature T
cells from immature precursors. It is unknown, however, whether
intratumorous thymopoiesis has an impact on the peripheral T-cell pool
and might thus be related to the high frequency of thymoma-associated
myasthenia gravis. This study shows, using fluorescence-activated cell
sorting-based analyses and T-cell proliferation assays, that
thymopoiesis and T-cell function in thymomas correspond with
immunologic alterations in the blood. Specifically, the proportion
of circulating CD45RA+CD8+ T cells is
significantly increased in patients with thymoma compared with normal
controls, in accordance with intratumorous T-cell development that
is abnormally skewed toward the CD8+ phenotype. Moreover,
it is primarily the proportion of circulating CD45RA+CD8+ T cells that decreases after
thymectomy. The results also demonstrate that T cells reactive toward
recombinant autoantigens are distributed equally between thymomas
and blood, whereas T-cell responses to foreign antigen (ie, tetanus
toxoid) are seen only among circulating T cells and not among
thymoma-derived T cells. These functional studies support the
hypothesis that thymopoiesis occurring within thymomas alters the
peripheral T-cell repertoire. Because many thymomas are enriched with
autoantigen-specific T cells, a disturbance of circulating T-cell
subset composition by export of intratumorous T cells may contribute to
paraneoplastic autoimmune disease arising in patients with thymoma.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E R Hammond, C A Pardo, and D A Kerr
Thymic hyperplasia in a patient with recurrent transverse myelitis with clinical resolution after thymectomy
J. Neurol. Neurosurg. Psychiatry,
March 1, 2008;
79(3):
334 - 335.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Amdahl, E. H. Alseth, N. E. Gilhus, H. L. Nakkestad, and G. O. Skeie
Polygenic Disease Associations in Thymomatous Myasthenia Gravis
Arch Neurol,
December 1, 2007;
64(12):
1729 - 1733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Ferri, M. Colaci, L. Battolla, D. Giuggioli, and M. Sebastiani
Thymus alterations and systemic sclerosis
Rheumatology,
January 1, 2006;
45(1):
72 - 75.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kondo and Y. Monden
Myasthenia gravis appearing after thymectomy for thymoma
Eur. J. Cardiothorac. Surg.,
July 1, 2005;
28(1):
22 - 25.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Karras, V. de Montpreville, F. Fakhouri, J.-P. Grunfeld, P. Lesavre, and for the Groupe d'Etudes des Nephropathies Associee
Renal and thymic pathology in thymoma-associated nephropathy: report of 21 cases and review of the literature
Nephrol. Dial. Transplant.,
June 1, 2005;
20(6):
1075 - 1082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Okumura, M. Ohta, Y. Takeuchi, H. Shiono, M. Inoue, K. Fukuhara, Y. Kadota, S. Miyoshi, Y. Fujii, and H. Matsuda
The immunologic role of thymectomy in the treatment of myasthenia gravis: implication of thymus-associated B-lymphocyte subset in reduction of the anti-acetylcholine receptor antibody titer
J. Thorac. Cardiovasc. Surg.,
December 1, 2003;
126(6):
1922 - 1928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shiono, Y. L. Wong, I. Matthews, J.-L. Liu, W. Zhang, G. Sims, A. Meager, D. Beeson, A. Vincent, and N. Willcox
Spontaneous production of anti-IFN-{alpha} and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor
Int. Immunol.,
August 1, 2003;
15(8):
903 - 913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Inoue, P. Starostik, A. Zettl, P. Strobel, S. Schwarz, F. Scaravilli, K. Henry, N. Willcox, H.-K. Muller-Hermelink, and A. Marx
Correlating Genetic Aberrations with World Health Organization-defined Histology and Stage across the Spectrum of Thymomas
Cancer Res.,
July 1, 2003;
63(13):
3708 - 3715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Masci, G. Palmieri, L. Vitiello, L. Montella, F. Perna, P. Orlandi, G. Abbate, S. Zappacosta, R. De Palma, and L. Racioppi
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia
Blood,
April 15, 2003;
101(8):
3106 - 3108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Evoli, C. Minisci, C. Di Schino, F. Marsili, C. Punzi, A. P. Batocchi, P. A. Tonali, G. B. Doglietto, P. Granone, L. Trodella, et al.
Thymoma in patients with MG: Characteristics and long-term outcome
Neurology,
December 24, 2002;
59(12):
1844 - 1850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. E. Somnier and P. J.H. Engel
The occurrence of anti-titin antibodies and thymomas: A population survey of MG 1970-1999
Neurology,
July 9, 2002;
59(1):
92 - 98.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Strobel, M. Helmreich, G. Menioudakis, S. R. Lewin, T. Rudiger, A. Bauer, V. Hoffacker, R. Gold, W. Nix, B. Schalke, et al.
Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas
Blood,
June 17, 2002;
100(1):
159 - 166.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
