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Blood, 15 December 2000, Vol. 96, No. 13, pp. 4039-4045
CHEMOKINES
I-309 binds to and activates endothelial cell functions and
acts as an angiogenic molecule in vivo
Giovanni Bernardini,
Gaia Spinetti,
Domenico Ribatti,
Grazia Camarda,
Lucia Morbidelli,
Marina Ziche,
Angela Santoni,
Maurizio C. Capogrossi, and
Monica Napolitano
From the Laboratory of Vascular Pathology, Istituto
Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere
Scientifico (IRCCS), Rome, Italy; Institute of Human Anatomy,
University of Bari, Italy; Institute of Pharmacological Sciences,
University of Siena, Italy; and Department of Experimental Medicine and
Pathology, University of Rome, "La Sapienza," Italy.
Several chemokines have been shown to act as angiogenic
molecules or to modulate the activity of growth factors such as
fibroblast growth factor 2 (FGF-2) and vascular endothelial growth
factor (VEGF). The detection of the CC chemokine receptor (CCR) 8 message in human umbilical vein endothelial cells (HUVECs) by reverse transcription- polymerase chain reaction (RT-PCR) and RNase
protection assay (RPA), prompted us to investigate the potential role
exerted by the CC chemokine I-309, a known ligand of such receptor, in both in vitro and in vivo angiogenesis assays. We show here that I-309
binds to endothelial cells, stimulates chemotaxis and invasion of these
cells, and enhances HUVEC differentiation into capillary-like structures in an in vitro Matrigel assay. Furthermore, I-309 is an
inducer of angiogenesis in vivo in both the rabbit cornea and the
chick chorioallantoic membrane assay (CAM).
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