|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 December 2000, Vol. 96, No. 13, pp. 4328-4334
NEOPLASIA
BAL is a novel risk-related gene in diffuse large
B-cell lymphomas that enhances cellular migration
Ricardo C. T. Aguiar,
Yoshihiro Yakushijin,
Samir Kharbanda,
Ravi Salgia,
Jonathan A. Fletcher, and
Margaret A. Shipp
From the Department of Adult Oncology, Dana-Farber
Cancer Institute, and the Department of Pathology, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA.
Clinical risk factor models such as the International Prognostic
Index are used to identify diffuse large B-cell lymphoma (DLB-CL)
patients with different risks of death from their diseases. To
elucidate the molecular bases for these observed clinical differences in outcome, differential display was used to identify a novel gene,
termed BAL (B-aggressive
lymphoma), which is expressed at significantly higher
levels in fatal high-risk DLB-CLs than in cured low-risk tumors. The
major BAL complementary DNA encodes a previously
uncharacterized 88-kd nuclear protein with a duplicated N-terminal
domain homologous to the nonhistone portion of histone-macroH2A and a
C-terminal alpha-helical region with 2 short coiled-coil domains. Of
note, the BAL N-terminus and secondary structure resemble those of a
recently identified human protein, KIAA1268. In addition, both
BAL and KIAA1268 map to chromosome 3q21,
further suggesting that these genes belong to a newly identified
family. BAL is expressed at increased levels in DLB-CL cell lines with
an activated peripheral B cell, rather than a germinal center B cell,
phenotype. This observation and the characteristic dissemination of
high risk DLB-CLs prompted studies regarding the role of BAL in B-cell
migration. In classical transwell assays, stable BAL-overexpressing
B-cell lymphoma transfectants had significantly higher rates of
migration than vector-only transfectants, indicating that the
risk-related BAL gene promotes malignant B-cell migration.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Teotia and R. S. Lamb
The Paralogous Genes RADICAL-INDUCED CELL DEATH1 and SIMILAR TO RCD ONE1 Have Partially Redundant Functions during Arabidopsis Development
Plant Physiology,
September 1, 2009;
151(1):
180 - 198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Cho, S. Goenka, T. Henttinen, P. Gudapati, A. Reinikainen, C. M. Eischen, R. Lahesmaa, and M. Boothby
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells
Blood,
March 12, 2009;
113(11):
2416 - 2425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yanagawa, T. Funasaka, S. Tsutsumi, H. Hu, H. Watanabe, and A. Raz
Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Activities by the Poly(ADP-Ribose) Polymerase Family-14
Cancer Res.,
September 15, 2007;
67(18):
8682 - 8689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Goenka, S. H. Cho, and M. Boothby
Collaborator of Stat6 (CoaSt6)-associated Poly(ADP-ribose) Polymerase Activity Modulates Stat6-dependent Gene Transcription
J. Biol. Chem.,
June 29, 2007;
282(26):
18732 - 18739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. O. Hassa, S. S. Haenni, M. Elser, and M. O. Hottiger
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Microbiol. Mol. Biol. Rev.,
September 1, 2006;
70(3):
789 - 829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Juszczynski, J. L. Kutok, C. Li, J. Mitra, R. C. T. Aguiar, and M. A. Shipp
BAL1 and BBAP Are Regulated by a Gamma Interferon-Responsive Bidirectional Promoter and Are Overexpressed in Diffuse Large B-Cell Lymphomas with a Prominent Inflammatory Infiltrate.
Mol. Cell. Biol.,
July 1, 2006;
26(14):
5348 - 5359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. E. Chou, H. T. Chou, and S.-C. Lee
CDK-dependent Activation of Poly(ADP-ribose) Polymerase Member 10 (PARP10)
J. Biol. Chem.,
June 2, 2006;
281(22):
15201 - 15207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Goenka and M. Boothby
Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor.
PNAS,
March 14, 2006;
103(11):
4210 - 4215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. T. Aguiar, K. Takeyama, C. He, K. Kreinbrink, and M. A. Shipp
B-aggressive Lymphoma Family Proteins Have Unique Domains That Modulate Transcription and Exhibit Poly(ADP-ribose) Polymerase Activity
J. Biol. Chem.,
October 7, 2005;
280(40):
33756 - 33765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. Smith, F. Wang, K. N. Wilkinson, K. J. Savage, U. Klein, D. S. Neuberg, G. Bollag, M. A. Shipp, and R. C. T. Aguiar
The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma
Blood,
January 1, 2005;
105(1):
308 - 316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. De, C. Fata-Hartley, S. G. Sawicki, and D. L. Sawicki
Functional Analysis of nsP3 Phosphoprotein Mutants of Sindbis Virus
J. Virol.,
December 15, 2003;
77(24):
13106 - 13116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Shi, H.-L. Hsu, A. M. Evens, L. I. Gordon, and R. B. Gartenhaus
Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies
Blood,
July 1, 2003;
102(1):
297 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Takeyama, R. C. T. Aguiar, L. Gu, C. He, G. J. Freeman, J. L. Kutok, J. C. Aster, and M. A. Shipp
The BAL-binding Protein BBAP and Related Deltex Family Members Exhibit Ubiquitin-Protein Isopeptide Ligase Activity
J. Biol. Chem.,
June 6, 2003;
278(24):
21930 - 21937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. T. Aguiar, G. Cox, S. L. Pomeroy, and P. L. M. Dahia
Analysis of the SDHD Gene, the Susceptibility Gene for Familial Paraganglioma Syndrome (PGL1), in Pheochromocytomas
J. Clin. Endocrinol. Metab.,
June 1, 2001;
86(6):
2890 - 2894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
