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Blood, 15 December 2000, Vol. 96, No. 13, pp. 4357-4359
BRIEF REPORT
Frequency and kinetics of polyclonal and clonal B cells in the
peripheral blood of patients being treated for multiple
myeloma
Thomas Rasmussen,
Linda Jensen,
Lone Honoré, and
Hans Erik Johnsen
From the Department of Hematology L, Herlev Hospital,
University of Copenhagen, Herlev, Denmark.
Recent studies concerning the numbers of circulating clonal B cells
in patients with multiple myeloma (MM) have reported conflicting data
regarding the exact level and phenotype of clonal B cells and their
response to treatment. In this report we document that the peripheral
blood tumor burden at presentation was reduced by induction therapy to
a low level, regardless of the initial tumor burden. However, the
residual clonal compartment persisted before and after transplant.
The level of clonal cells showed no correlation with CD19+
cell levels. In a single patient with MM, high numbers of
phenotypically aberrant clonal cells with altered CD19 expression were identified.
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Related Letter in Blood Online:
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Clonotypic B cells in the peripheral blood of patients with multiple myeloma
- Friedrich W. Cremer, Hartmut Goldschmidt, Marion Moos, Thomas Rasmussen, and Hans Erik Johnsen
Blood 2001 97: 2913-2914.
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