|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 96 No. 3 (August 1), 2000:
pp. 1064-1069
B-cell-autonomous somatic mutation deficit following bone marrow
transplant
Annuska M. Glas,
Erwin H. N. van Montfort,
Jan Storek,
Emily-Gene N. Green,
Roy P. M. Drissen,
Viviane J. Bechtold,
J. Zachary Reilly,
Monja A. Dawson, and
Eric C. B. Milner
From the Virginia Mason Research Center and the Fred Hutchinson
Cancer Research Center, Seattle, WA.
Hematopoietic stem cell transplantation is characterized by a
prolonged period of humoral immunodeficiency. We have previously shown
that the deficiencies are probably not due to the failure to utilize
the appropriate V regions in the pre-immune repertoire. However, a
striking observation, which correlated with the absence of
immunoglobulin IgD cells and was consistent with a
defect in antigen-driven responses, was that rearrangements in bone
marrow transplant (BMT) recipients exhibited much less somatic mutation
than did rearrangements obtained from healthy subjects. In this paper,
we present evidence suggesting that naive B cells obtained from BMT
recipients lack the capacity to accumulate somatic mutations in a
T-cell-dependent manner compared with healthy subjects. This appears
to be a B-cell-autonomous deficit because T cells from some patients,
which were not able to support the accumulation of mutations in
autologous naive B cells, were able to support accumulation of
mutations in heterologous healthy-subject naive B cells.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. M. Uttenreuther-Fischer, J. A. Kruger, and P. Fischer
Molecular Characterization of the Anti-Idiotypic Immune Response of a Relapse-Free Neuroblastoma Patient following Antibody Therapy: A Possible Vaccine against Tumors of Neuroectodermal Origin?
J. Immunol.,
June 15, 2006;
176(12):
7775 - 7786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. H. Sasso, M. Martinez, S. L. Yarfitz, P. Ghillani, L. Musset, J.-C. Piette, and P. Cacoub
Frequent Joining of Bcl-2 to a JH6 Gene in Hepatitis C Virus-Associated t(14;18)
J. Immunol.,
September 1, 2004;
173(5):
3549 - 3556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. F. Lausen, L. Hougs, L. Schejbel, C. Heilmann, and T. Barington
Human Memory B Cells Transferred by Allogenic Bone Marrow Transplantation Contribute Significantly to the Antibody Repertoire of the Recipient
J. Immunol.,
March 1, 2004;
172(5):
3305 - 3318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Storek, F. Viganego, M. A. Dawson, M. M. P. T. Herremans, M. Boeckh, M. E. D. Flowers, B. Storer, W. I. Bensinger, R. P. Witherspoon, and D. G. Maloney
Factors affecting antibody levels after allogeneic hematopoietic cell transplantation
Blood,
April 15, 2003;
101(8):
3319 - 3324.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Waldschmidt, A. Panoskaltsis-Mortari, R. T. McElmurry, L. T. Tygrett, P. A. Taylor, and B. R. Blazar
Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero
Blood,
December 15, 2002;
100(13):
4557 - 4564.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
