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Blood, Vol. 96 No. 3 (August 1), 2000:
pp. 1177-1179
BRIEF REPORT
 -Fibrinogen Thr312Ala polymorphism and venous
thromboembolism
Angela M. Carter,
Andrew J. Catto,
Hans P. Kohler,
Robert A. S. Ariëns,
Max H. Stickland, and
Peter J. Grant
From the Academic Unit of Molecular Vascular Medicine, Research
School of Medicine, University of Leeds, Leeds General Infirmary,
Leeds, England.
The A -fibrinogen Thr312Ala polymorphism, which occurs in a
region involved in factor XIII (FXIII)-dependent cross-linking processes, is associated with poststroke mortality in subjects with
atrial fibrillation, suggesting an influence either on intraatrial clot
formation or embolization. We have determined the association of
Thr312Ala with deep vein thrombosis (DVT) and pulmonary
embolism (PE) and have assessed the interaction of Thr312Ala
with the FXIII Val34Leu polymorphism in 122 patients with DVT, 99 patients with PE, and 254 healthy control subjects.
The genotype distribution of patients with PE
(TT = 49%, TA = 36%, AA = 15%), but not DVT (TT = 50%, TA = 42%, AA = 8%), differed significantly
from healthy control subjects (TT = 60%, TA = 34%,
AA = 6%, P = .02). A significant interaction of
Thr312Ala and Val34Leu was also identified (P = .01),
indicating an inverse association between Leu34 and Ala312. These
results support the hypothesis that Thr312Ala alters FXIII-dependent cross-linking, making formed fibrin clot more susceptible to embolization.
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