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Blood, Vol. 96 No. 3 (August 1), 2000:
pp. 1180-1183
BRIEF REPORT
Splenectomy selectively affects the distribution and mobility of
the recirculating lymphocyte pool
Tim J. Seabrook,
Wayne R. Hein,
Lisbeth Dudler, and
Alan J. Young
From the Basel Institute for Immunology, Basel, Switzerland.
The spleen plays a major role in immune surveillance, but the impact
that splenectomy exerts on the immune competence of an individual is
not fully resolved. Here we show that neonatal splenectomy in sheep
does not abrogate the development of a large, nonrecirculating pool of
lymphocytes and that it has no effect on the acquisition of a normal
blood lymphocyte profile. Splenectomy did, however, result in a
significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating
lymphocytes in lymph nodes. Furthermore, nonrecirculating peripheral
blood lymphocytes were less likely to migrate to the lung, possibly because of saturation of the marginal pool by recirculating
lymphocytes. Although splenectomy has little effect on the development
or distribution of lymphocyte subsets in blood and lymph, it has marked
effects on the rate of recirculation of lymphocytes, which may have
significant implications for peripheral immune surveillance in patients
who undergo splenectomy.
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