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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maraskovsky, E. Articles by McKenna, H. J. Search for Related Content PubMed PubMed Citation Articles by Maraskovsky, E. Articles by McKenna, H. J. Related Collections Hematopoiesis and Stem Cells Immunobiology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 96 No. 3 (August 1), 2000: pp. 878-884 In vivo generation of human dendritic cell subsets by Flt3 ligand Eugene Maraskovsky, Elizabeth Daro, Eileen Roux, Mark Teepe, Charlie R. Maliszewski, Jeannie Hoek, Dania Caron, Mel E. Lebsack, and Hilary J. McKenna From Immunex Corporation, Seattle, WA. Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their use as vectors for immunotherapy vaccines. However, it is unclear whether and to what degree in vitro-generated DCs are representative of DCs that develop in vivo. Treatment of mice with human Flt3 ligand (FL) dramatically increases the number of DCs. We report here that administration of FL to healthy human volunteers increased the number of circulating CD11c+ IL-3Rlow DC (mean 44-fold) and CD11c IL-3Rhigh DC precursors (mean 12-fold). Moreover, the CD11c+ DCs were efficient stimulators of T cells in vitro. Thus, FL can expand the number of circulating, functionally competent human DCs in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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Wodnar-Filipowicz Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand Blood, May 15, 2004; 103(10): 3860 - 3868. [Abstract] [Full Text] [PDF] W. Chen, S. Antonenko, J. M. Sederstrom, X. Liang, A. S. H. Chan, H. Kanzler, B. Blom, B. R. Blazar, and Y.-J. Liu Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors Blood, April 1, 2004; 103(7): 2547 - 2553. [Abstract] [Full Text] [PDF] J. Taieb, K. Maruyama, C. Borg, M. Terme, L. Zitvogel, S. Appel, and P. Brossart Imatinib mesylate impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo Blood, March 1, 2004; 103(5): 1966 - 1967. [Full Text] [PDF] C. S. Higano, N. J. Vogelzang, J. A. Sosman, A. Feng, D. Caron, and E. J Small Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer Clin. Cancer Res., February 15, 2004; 10(4): 1219 - 1225. [Abstract] [Full Text] [PDF] A. Wodnar-Filipowicz Flt3 Ligand: Role in Control of Hematopoietic and Immune Functions of the Bone Marrow Physiology, December 1, 2003; 18(6): 247 - 251. [Abstract] [Full Text] [PDF] R. S. Freedman, S. Vadhan-Raj, C. Butts, C. Savary, B. Melichar, C. Verschraegen, J. J. Kavanagh, M. E. Hicks, L. B. Levy, J. K. Folloder, et al. Pilot Study of Flt3 Ligand Comparing Intraperitoneal with Subcutaneous Routes on Hematologic and Immunologic Responses in Patients with Peritoneal Carcinomatosis and Mesotheliomas Clin. Cancer Res., November 1, 2003; 9(14): 5228 - 5237. [Abstract] [Full Text] [PDF] P. T. H. Coates, S. M. Barratt-Boyes, L. Zhang, V. S. Donnenberg, P. J. O'Connell, A. J. Logar, F. J. Duncan, M. Murphey-Corb, A. D. Donnenberg, A. E. Morelli, et al. Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand Blood, October 1, 2003; 102(7): 2513 - 2521. [Abstract] [Full Text] [PDF] M. Jefford, M. Schnurr, T. Toy, K.-A. Masterman, A. Shin, T. Beecroft, T. Y. Tai, K. Shortman, M. Shackleton, I. D. Davis, et al. Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli Blood, September 1, 2003; 102(5): 1753 - 1763. [Abstract] [Full Text] [PDF] A. D'Amico and L. Wu The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3 J. Exp. Med., July 21, 2003; 198(2): 293 - 303. [Abstract] [Full Text] [PDF] T. E. Toliver-Kinsky, C. Y. Lin, D. N. Herndon, and E. R. Sherwood Stimulation of Hematopoiesis by the Fms-Like Tyrosine Kinase 3 Ligand Restores Bacterial Induction of Th1 Cytokines in Thermally Injured Mice Infect. Immun., June 1, 2003; 71(6): 3058 - 3067. [Abstract] [Full Text] [PDF] D. J. Manfra, S.-C. Chen, K. K. Jensen, J. S. Fine, M. T. Wiekowski, and S. A. Lira Conditional Expression of Murine Flt3 Ligand Leads to Expansion of Multiple Dendritic Cell Subsets in Peripheral Blood and Tissues of Transgenic Mice J. Immunol., March 15, 2003; 170(6): 2843 - 2852. [Abstract] [Full Text] [PDF] S. Vuckovic, M. Kim, D. Khalil, C. J. Turtle, G. V. Crosbie, N. Williams, L. Brown, K. Williams, C. Kelly, P. Stravos, et al. Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression Blood, March 15, 2003; 101(6): 2314 - 2317. [Abstract] [Full Text] [PDF] G. Sailaja, S. Husain, B. P. Nayak, and A. M. 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Immunol., December 15, 2002; 169(12): 6711 - 6719. [Abstract] [Full Text] [PDF] W. Mwangi, W. C. Brown, H. A. Lewin, C. J. Howard, J. C. Hope, T. V. Baszler, P. Caplazi, J. Abbott, and G. H. Palmer DNA-Encoded Fetal Liver Tyrosine Kinase 3 Ligand and Granulocyte Macrophage-Colony-Stimulating Factor Increase Dendritic Cell Recruitment to the Inoculation Site and Enhance Antigen-Specific CD4+ T Cell Responses Induced by DNA Vaccination of Outbred Animals J. Immunol., October 1, 2002; 169(7): 3837 - 3846. [Abstract] [Full Text] [PDF] P. J Mosca, A. C. Hobeika, K. Colling, T. M. Clay, E. K. Thomas, D. Caron, H. K. Lyerly, and M. A. Morse Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand J. Leukoc. Biol., September 1, 2002; 72(3): 546 - 553. [Abstract] [Full Text] [PDF] D. G. Gilliland and J. D. Griffin The roles of FLT3 in hematopoiesis and leukemia Blood, August 13, 2002; 100(5): 1532 - 1542. [Abstract] [Full Text] [PDF] T. Luft, M. Jefford, P. Luetjens, T. Toy, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E2 regulates the migratory capacity of specific DC subsets Blood, July 30, 2002; 100(4): 1362 - 1372. [Abstract] [Full Text] [PDF] M. R. Comeau, A.-R. Van der Vuurst de Vries, C. R. Maliszewski, and L. Galibert CD123bright Plasmacytoid Predendritic Cells: Progenitors Undergoing Cell Fate Conversion? J. Immunol., July 1, 2002; 169(1): 75 - 83. [Abstract] [Full Text] [PDF] R. J. Steptoe, J. M. Ritchie, and L. C. Harrison Increased Generation of Dendritic Cells from Myeloid Progenitors in Autoimmune-Prone Nonobese Diabetic Mice J. Immunol., May 15, 2002; 168(10): 5032 - 5041. [Abstract] [Full Text] [PDF] M. L. Disis, K. Rinn, K. L. Knutson, D. Davis, D. Caron, C. dela Rosa, and K. Schiffman Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers Blood, April 15, 2002; 99(8): 2845 - 2850. [Abstract] [Full Text] [PDF] M. O'Keeffe, H. Hochrein, D. Vremec, J. Pooley, R. Evans, S. Woulfe, and K. Shortman Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice Blood, March 15, 2002; 99(6): 2122 - 2130. [Abstract] [Full Text] [PDF] J. M. Timmerman, D. K. Czerwinski, T. A. Davis, F. J. Hsu, C. Benike, Z. M. Hao, B. Taidi, R. Rajapaksa, C. B. Caspar, C. Y. Okada, et al. Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients Blood, March 1, 2002; 99(5): 1517 - 1526. [Abstract] [Full Text] [PDF] T. Luft, M. Jefford, P. Luetjens, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky IL-1{beta} Enhances CD40 Ligand-Mediated Cytokine Secretion by Human Dendritic Cells (DC): A Mechanism for T Cell-Independent DC Activation J. Immunol., January 15, 2002; 168(2): 713 - 722. [Abstract] [Full Text] [PDF] M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF] P. J. O'Connell, W. Li, Z. Wang, S. M. Specht, A. J. Logar, and A. W. Thomson Immature and Mature CD8{alpha}+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts J. Immunol., January 1, 2002; 168(1): 143 - 154. [Abstract] [Full Text] [PDF] H. Donaghy, A. Pozniak, B. Gazzard, N. Qazi, J. Gilmour, F. Gotch, and S. Patterson Loss of blood CD11c+ myeloid and CD11c{-} plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load Blood, October 15, 2001; 98(8): 2574 - 2576. [Abstract] [Full Text] [PDF] V. Soumelis, I. Scott, F. Gheyas, D. Bouhour, G. Cozon, L. Cotte, L. Huang, J. A. Levy, and Y.-J. Liu Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients Blood, August 15, 2001; 98(4): 906 - 912. [Abstract] [Full Text] [PDF] S. R. Riddell Progress in cancer vaccines by enhanced self-presentation PNAS, July 31, 2001; 98(16): 8933 - 8935. [Full Text] [PDF] G.B. Toews Cytokines and the lung Eur. Respir. J., July 2, 2001; 18(34_suppl): 3S - 17s. [Abstract] [Full Text] [PDF] A. Curti, M. Fogli, M. Ratta, S. Tura, and R. M. Lemoli Stem Cell Factor and FLT3-Ligand Are Strictly Required to Sustain the Long-Term Expansion of Primitive CD34+DR- Dendritic Cell Precursors J. Immunol., January 15, 2001; 166(2): 848 - 854. [Abstract] [Full Text] [PDF] J. Banchereau, B. Pulendran, R. Steinman, and K. Palucka Will the Making of Plasmacytoid Dendritic Cells in Vitro Help Unravel Their Mysteries? J. Exp. Med., December 18, 2000; 192(12): f39 - f44. [Full Text] [PDF] J. Baggers, G. Ratzinger, and J. W. Young Dendritic Cells as Immunologic Adjuvants for the Treatment of Cancer J. Clin. Oncol., December 1, 2000; 18(23): 3879 - 3882. [Full Text] [PDF] L. Fong, Y. Hou, A. Rivas, C. Benike, A. Yuen, G. A. Fisher, M. M. Davis, and E. G. Engleman Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy PNAS, July 17, 2001; 98(15): 8809 - 8814. [Abstract] [Full Text] [PDF]

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