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Blood, 15 August 2000, Vol. 96, No. 4, pp. 1433-1437
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Platelet adhesion to collagen in healthy volunteers is influenced
by variation of both  2 1 density and
von Willebrand factor
Mark Roest,
Jan J. Sixma,
Ya-Ping Wu,
Martin J. W. Ijsseldijk,
Mariëlle Tempelman,
Pieter J. Slootweg,
Philip
G. de Groot, and
G. Henrita van Zanten
From the Laboratory of Thrombosis and Haemostasis,
Department of Hematology, Julius Center for Patient Oriented Research,
and Department of Pathology, University Medical Center Utrecht,
Utrecht, The Netherlands.
Platelet thrombus formation on collagen is initiated by platelet
GPIb interaction with von Willebrand factor (vWF) bound to collagen, followed by firm attachment of the platelet to collagen by
the integrin  2 1. Platelet and plasma vWF
levels and 21 density on the platelet
surface are highly variable among normal subjects; however, little is
known about the consequences of this variability on platelet adhesion
to collagen. A population of 32 normal subjects was studied to evaluate
the relation between genetic and phenotypic variations of
21 density on the platelet surface,
plasma vWF levels, platelet vWF levels, and adenosine diphosphate and
adenosine triphosphate concentrations on the one hand and platelet
adhesion to collagen under flow on the other hand. Platelet adhesion to
collagen types I and III under flow was correlated with plasma levels
of vWF (r2 = 0.45 and 0.42, respectively) and 21 density on the
platelet surface (r2 = 0.35 and
0.17, not significant). Platelet adhesion to collagen type IV under
flow was significantly correlated with platelet vWF levels
(r2 = 0.34) and
21 density on the platelet surface
(r2 = 0.42). Platelet adhesion to
collagen types I and III depends on both plasma levels of vWF and
21 density on the platelet surface,
whereas platelet adhesion to collagen type IV is mediated by both
platelet vWF levels and 21 density on the
platelet surface.
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