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Blood, 15 August 2000, Vol. 96, No. 4, pp. 1599-1601
BRIEF REPORT
Viral and cellular cytokines in AIDS-related malignant
lymphomatous effusions
Yoshiyasu Aoki,
Robert Yarchoan,
James Braun,
Aikichi Iwamoto, and
Giovanna Tosato
From the Medicine Branch and HIV and AIDS Malignancy
Branch, National Cancer Institute, National Institutes of Health,
Bethesda, MD; Department of Medicine, St Vincent's Hospital
and Medical Center, New York, NY; and the Department of Infectious
Disease, Institute of Medical Science, University of Tokyo, Tokyo,
Japan.
Kaposi sarcoma-associated herpesvirus encodes viral IL-6
(vIL-6). To investigate the potential role of vIL-6 in the pathogenesis of human immunodeficiency virus (HIV)- related primary effusion lymphomas (PEL), a sensitive enzyme-linked immunosorbent assay was
developed for vIL-6 and applied to the study of PEL. Whereas vIL-6 was
detectable in 6 of 8 PEL effusions (range, 1390-66 630 pg/mL), it was
not detectable in any of the control effusions. As expected, all PEL
effusions contained human IL-6 (range, 957-37 494 pg/mL), and 7 of 8 contained detectable human IL-10 (range, 66-2,521,297 pg/mL). Human and
vIL-6 have previously been shown to induce vascular endothelial growth
factor, which in turn can increase vascular permeability. The results
of the current study suggest that these cytokines play a central role
in the pathogenesis and manifestations of PEL.
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