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Blood, 1 September 2000, Vol. 96, No. 5, pp. 1633-1637
PLENARY PAPER
Langerhans cells develop from a lymphoid-committed
precursor
Fabienne Anjuère,
Gloria Martínez del
Hoyo,
Pilar Martín, and
Carlos Ardavín
From the Department of Cell Biology, Faculty of
Biology, Complutense University, Madrid, Spain.
Langerhans cells (LCs) are specialized dendritic cells (DCs)
strategically located in stratified epithelia, such as those of the
skin, oral cavity, pharynx, esophagus, upper airways, urethra, and female reproductive tract, which are exposed to a wide variety of
microbial pathogens. LCs play an essential role in the induction of
T-lymphocyte responses against viruses, bacteria, and parasites that
gain access to those epithelial surfaces, due to their high antigen
capture and processing potential and their capacity to present antigen
peptides to T cells on migration to the lymph nodes.1
Although LCs have been classically considered of myeloid origin, recent
reports, which demonstrate the existence of lymphoid DCs derived from
multipotent lymphoid precursors devoid of myeloid differentiation
potential,2-5 raise the question of the lymphoid or
myeloid origin of LCs. The present study shows that mouse
lymphoid-committed CD4low precursors, with the capacity to
generate T cells, B cells, CD8+ lymphoid DCs, and natural
killer cells,26 also generate epidermal LCs on
intravenous transfer, supporting the view that LCs belong to the
lymphoid lineage.
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