SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dawson, T. C. Articles by Peiper, S. C. Search for Related Content PubMed PubMed Citation Articles by Dawson, T. C. Articles by Peiper, S. C. Related Collections Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2000, Vol. 96, No. 5, pp. 1681-1684 Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC) Tracey C. Dawson, Alex B. Lentsch, Zixuan Wang, John E. Cowhig, Antal Rot, Nobuyo Maeda, and Stephen C. Peiper From the Department of Pathology, University of North Carolina, Chapel Hill, NC; Departments of Surgery and Pathology, J. G. Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY; and Novartis Forschungsinstitut, Vienna, Austria. Duffy antigen/receptor for chemokines (DARC) is a promiscuous receptor for chemokines that is required for Plasmodium vivax infection of erythroid cells. This receptor is expressed by subsets of endothelial, as well as erythroid cells. Selection for protection from malaria infection resulted in an erythroid-specific defect, suggesting that DARC may play a critical role in endothelial biology. Mice with targeted disruption of this gene were generated, and the function of DARC in inflammation was explored. RNA from spleens of homozygous mutant mice lacked DARC transcripts, which were abundant in wild-type (+/+) and heterozygote (+/) mice. DARC/ mice lacked developmental abnormalities and were healthy at 1 year. Whereas hematologic parameters were within normal ranges, erythrocytes from nullizygous mice lacked CXC and CC chemokine-binding activity. Challenge with lipopolysaccharide resulted in significantly increased inflammatory infiltrates in lung and liver of nullizygous mice. These results suggest that DARC modulates the intensity of inflammatory reactions as a sink for chemokines. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Zerfaoui, A. S. Naura, Y. Errami, C. P. Hans, B. M. Rezk, J. Park, W. Elsegeiny, H. Kim, K. Lord, J. G. Kim, et al. Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines J. Leukoc. Biol., December 1, 2009; 86(6): 1385 - 1392. [Abstract] [Full Text] [PDF] V. Vielhauer, R. Allam, M. T. Lindenmeyer, C. D. Cohen, D. Draganovici, J. Mandelbaum, N. Eltrich, P. J. Nelson, H.-J. Anders, M. Pruenster, et al. Efficient Renal Recruitment of Macrophages and T Cells in Mice Lacking the Duffy Antigen/Receptor for Chemokines Am. J. Pathol., July 1, 2009; 175(1): 119 - 131. [Abstract] [Full Text] [PDF] C. Vergara, Y. J. Tsai, A. V. Grant, N. Rafaels, L. Gao, T. Hand, M. Stockton, M. Campbell, D. Mercado, M. Faruque, et al. Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations Am. J. Respir. Crit. Care Med., November 15, 2008; 178(10): 1017 - 1022. [Abstract] [Full Text] [PDF] T. Yoshimura and J. J. Oppenheim Chemerin reveals its chimeric nature J. Exp. Med., September 29, 2008; 205(10): 2187 - 2190. [Abstract] [Full Text] [PDF] A. Chakera, R. M. Seeber, A. E. John, K. A. Eidne, and D. R. Greaves The Duffy Antigen/Receptor for Chemokines Exists in an Oligomeric Form in Living Cells and Functionally Antagonizes CCR5 Signaling through Hetero-Oligomerization Mol. Pharmacol., May 1, 2008; 73(5): 1362 - 1370. [Abstract] [Full Text] [PDF] J. S. Lee, M. M. Wurfel, G. Matute-Bello, C. W. Frevert, M. R. Rosengart, M. Ranganathan, V. W. Wong, T. Holden, S. Sutlief, A. Richmond, et al. The Duffy Antigen Modifies Systemic and Local Tissue Chemokine Responses following Lipopolysaccharide Stimulation J. Immunol., December 1, 2006; 177(11): 8086 - 8094. [Abstract] [Full Text] [PDF] H. Shen, R. Schuster, K. F. Stringer, S. E. Waltz, and A. B. Lentsch The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth FASEB J, January 1, 2006; 20(1): 59 - 64. [Abstract] [Full Text] [PDF] H. Bruhl, V. Vielhauer, M. Weiss, M. Mack, D. Schlondorff, and S. Segerer Expression of DARC, CXCR3 and CCR5 in giant cell arteritis Rheumatology, March 1, 2005; 44(3): 309 - 313. [Abstract] [Full Text] [PDF] E. Galliera, V. R. Jala, J. O. Trent, R. Bonecchi, P. Signorelli, R. J. Lefkowitz, A. Mantovani, M. Locati, and B. Haribabu {beta}-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6 J. Biol. Chem., June 11, 2004; 279(24): 25590 - 25597. [Abstract] [Full Text] [PDF] H. Shen and A. B. Lentsch Progressive dysregulation of transcription factors NF-{kappa}B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines Am J Physiol Cell Physiol, April 1, 2004; 286(4): C840 - C847. [Abstract] [Full Text] [PDF] M. Kashiwazaki, T. Tanaka, H. Kanda, Y. Ebisuno, D. Izawa, N. Fukuma, N. Akimitsu, K. Sekimizu, M. Monden, and M. Miyasaka A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions Int. Immunol., October 1, 2003; 15(10): 1219 - 1227. [Abstract] [Full Text] [PDF] J. S. Lee, C. W. Frevert, M. M. Wurfel, S. C. Peiper, V. A. Wong, K. K. Ballman, J. T. Ruzinski, J. S. Rhim, T. R. Martin, and R. B. Goodman Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In Vitro and In Vivo J. Immunol., May 15, 2003; 170(10): 5244 - 5251. [Abstract] [Full Text] [PDF] M. GOTTE Syndecans in inflammation FASEB J, April 1, 2003; 17(6): 575 - 591. [Abstract] [Full Text] [PDF] J. S. Lee, C. W. Frevert, D. R. Thorning, S. Segerer, C. E. Alpers, J.-P. Cartron, Y. Colin, V. A. Wong, T. R. Martin, and R. B. Goodman Enhanced Expression of Duffy Antigen in the Lungs During Suppurative Pneumonia J. Histochem. Cytochem., February 1, 2003; 51(2): 159 - 166. [Abstract] [Full Text] [PDF] J. Middleton, A. M. Patterson, L. Gardner, C. Schmutz, and B. A. Ashton Leukocyte extravasation: chemokine transport and presentation by the endothelium Blood, December 1, 2002; 100(12): 3853 - 3860. [Abstract] [Full Text] [PDF] A. B. LENTSCH The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white? FASEB J, July 1, 2002; 16(9): 1093 - 1095. [Abstract] [Full Text] [PDF] C. J. Swardson-Olver, T. C. Dawson, R. C. Burnett, S. C. Peiper, N. Maeda, and A. C. Avery Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion Blood, April 15, 2002; 99(8): 2677 - 2684. [Abstract] [Full Text] [PDF] J. Du, J. Luan, H. Liu, T. O. Daniel, S. Peiper, T. S. Chen, Y. Yu, L. W. Horton, L. B. Nanney, R. M. Strieter, et al. Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress J. Leukoc. Biol., January 1, 2002; 71(1): 141 - 153. [Abstract] [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020