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Blood, 1 September 2000, Vol. 96, No. 5, pp. 1853-1856

IMMUNOBIOLOGY

Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4+ T lymphocytes

Reinhard Maier, María Matilde Bartolomé-Rodríguez, Corinne Moulon, Hans Ulrich Weltzien, and Andreas Meyerhans

From the Department of Virology, Institute of Medical Microbiology and Hygiene, Homburg, Germany; and Max-Planck Institute of Immunbiology, Freiburg, Germany.

The chemokine receptors CCR5 and CXCR4 are coreceptors for the human immunodeficiency virus (HIV) and determine the cell tropism of different HIV strains. Previous studies on their regulation were performed under conditions of unspecific T-lymphocyte stimulation and provided conflicting results. To mimick physiologic conditions, highly purified primary Staphylococcus enterotoxin B (SEB)-reactive CD4 T lymphocytes were stimulated in the presence of autologous antigen-presenting cells and the kinetics of CCR5 and CXCR4 surface expression and HIV replication were studied. Both chemokine receptors were transiently up-regulated with maximal expression at day 3 after stimulation. The stimulated T cells were equally susceptible to productive infection with R5-and X4-tropic virus strains. Thus, antigenic stimulation of T cells promotes efficient replication of both, T cell-tropic and macrophage-tropic HIV.

© 2000 by The American Society of Hematology.
 

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