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Related Collections Neoplasia Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2000, Vol. 96, No. 5, pp. 1921-1925 NEOPLASIA Prognostic significance of survivin expression in diffuse large B-cell lymphomas Colette Adida, Corinne Haioun, Philippe Gaulard, Eric Lepage, Pierre Morel, Josette Briere, Hervé Dombret, Felix Reyes, Jacques Diebold, Christian Gisselbrecht, Gilles Salles, Dario C. Altieri, and Thierry J. Molina From the Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT; Service d'Hématologie, Département de Pathologie, and Unité d'Informatique Médicale, Hôpital Henri Mondor, AP-HP, Créteil, France; Service d'Hématologie, Centre Hospitalier du Dr Schaffner, Lens, France; Service d'Anatomie Pathologique, AP-HP, and Institut d'Hématologie, Hôpital Saint-Louis, Paris, France; Service d'Anatomie Pathologique, Hôtel-Dieu, AP-HP, Paris, France; and Service d'Hématologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France. Survivin is an inhibitor of apoptosis overexpressed in various human cancers but undetectable in normal differentiated tissues. A potential expression and prognostic significance of survivin was studied in 222 patients with diffuse large B-cell lymphomas (centroblastic, 96%; immunoblastic, 4%). All patients were enrolled between 1987 and 1993 (median follow-up, 7 years) in the LNH87 protocol of the Groupe d'Etudes des Lymphomes de l'Adulte (GELA) and treated either with the reference ACVBP arm (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)[AU3A] (n = 79) or other experimental anthracycline-containing regimens (n = 143). The characteristics of these patients were median age of 56 years; serum lactate dehydrogenase (LDH) greater than 1N, 60%; stage III-IV, 55%; performance status, according to the Eastern Cooperative Oncology Group (ECOG) scale, more than 1, 23%; extranodal sites more than 1, 29%; mass more than 10 cm, 44%; bone marrow involvement, 15%. Of the 222 patients studied, 134 (60%) revealed survivin expression in virtually all tumor cells by immunohistochemistry. The overall 5-year survival rate was significantly lower in patients with survivin expression than in those without (40% vs 54%, P = .02). Multivariate analysis incorporating prognostic factors from the International Prognostic Index (IPI) identified survivin expression as an independent predictive parameter on survival (P = .03, relative risk [RR] = 1.6) in addition to LDH (P = .02, RR = 1.6), stage (P = .03, RR = 1.7), and ECOG scale (P = .05, RR = 1.6). A second analysis incorporating IPI as a unique parameter demonstrated that survivin expression (P = .02, RR = 1.6) remained a prognostic factor for survival independently of IPI (P = .001, RR = 1.5). Survivin expression may be considered a new unfavorable prognostic factor of diffuse large B-cell lymphoma. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Lu, S. C. Verma, M. Murakami, Q. Cai, P. Kumar, B. Xiao, and E. S. Robertson Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation J. Virol., July 15, 2009; 83(14): 7129 - 7141. [Abstract] [Full Text] [PDF] D de Jong, W Xie, A Rosenwald, M Chhanabhai, P Gaulard, W Klapper, A Lee, B Sander, C Thorns, E Campo, et al. Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium) J. Clin. Pathol., February 1, 2009; 62(2): 128 - 138. [Abstract] [Full Text] [PDF] A. W. Tolcher, A. Mita, L. D. Lewis, C. R. Garrett, E. Till, A. I. Daud, A. Patnaik, K. Papadopoulos, C. Takimoto, P. Bartels, et al. Phase I and Pharmacokinetic Study of YM155, a Small-Molecule Inhibitor of Survivin J. Clin. Oncol., November 10, 2008; 26(32): 5198 - 5203. [Abstract] [Full Text] [PDF] A. C. 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Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines Blood, June 15, 2006; 107(12): 4880 - 4887. [Abstract] [Full Text] [PDF] H. Kojima, M. Iida, Y. Yaguchi, R. Suzuki, N. Hayashi, H. Moriyama, and Y. Manome Enhancement of Cisplatin sensitivity in squamous cell carcinoma of the head and neck transfected with a survivin antisense gene. Arch Otolaryngol Head Neck Surg, June 1, 2006; 132(6): 682 - 685. [Abstract] [Full Text] [PDF] S. Fukuda and L. M. Pelus Survivin, a cancer target with an emerging role in normal adult tissues Mol. Cancer Ther., May 1, 2006; 5(5): 1087 - 1098. [Abstract] [Full Text] [PDF] I. S. Lossos and D. Morgensztern Prognostic Biomarkers in Diffuse Large B-Cell Lymphoma J. Clin. Oncol., February 20, 2006; 24(6): 995 - 1007. [Abstract] [Full Text] [PDF] B. Z. Carter, D. H. Mak, W. D. Schober, M. Cabreira-Hansen, M. Beran, T. McQueen, W. Chen, and M. 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B. de Kok Survivin Is an Independent Prognostic Marker for Risk Stratification of Breast Cancer Patients Clin. Chem., November 1, 2004; 50(11): 1986 - 1993. [Abstract] [Full Text] [PDF] K. H. Emami, C. Nguyen, H. Ma, D. H. Kim, K. W. Jeong, M. Eguchi, R. T. Moon, J.-L. Teo, S. W. Oh, H. Y. Kim, et al. A small molecule inhibitor of {beta}-catenin/CREB-binding protein transcription PNAS, August 24, 2004; 101(34): 12682 - 12687. [Abstract] [Full Text] [PDF] I. Tamm, S. Richter, D. Oltersdorf, U. Creutzig, J. Harbott, F. Scholz, L. Karawajew, W.-D. Ludwig, and C. Wuchter High Expression Levels of X-Linked Inhibitor of Apoptosis Protein and Survivin Correlate with Poor Overall Survival in Childhood de Novo Acute Myeloid Leukemia Clin. Cancer Res., June 1, 2004; 10(11): 3737 - 3744. [Abstract] [Full Text] [PDF] E. J. Schlette, L. J. Medeiros, A. Goy, R. Lai, and G. Z. Rassidakis Survivin Expression Predicts Poorer Prognosis in Anaplastic Large-Cell Lymphoma J. Clin. 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Pelus Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34+ cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis Blood, October 1, 2001; 98(7): 2091 - 2100. [Abstract] [Full Text] [PDF] D. S. Rickman, M. P. Bobek, D. E. Misek, R. Kuick, M. Blaivas, D. M. Kurnit, J. Taylor, and S. M. Hanash Distinctive Molecular Profiles of High-Grade and Low-Grade Gliomas Based on Oligonucleotide Microarray Analysis Cancer Res., September 1, 2001; 61(18): 6885 - 6891. [Abstract] [Full Text] [PDF] I. S. Lossos, C. D. Jones, R. Warnke, Y. Natkunam, H. Kaizer, J. L. Zehnder, R. Tibshirani, and R. Levy Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma Blood, August 15, 2001; 98(4): 945 - 951. [Abstract] [Full Text] [PDF] M. H. Andersen, L. O. Pedersen, B. Capeller, E.-B. Brocker, J. C. Becker, and P. thor Straten Spontaneous Cytotoxic T-Cell Responses against Survivin-derived MHC Class I-restricted T-Cell Epitopes in Situ As Well As ex Vivo in Cancer Patients Cancer Res., August 1, 2001; 61(16): 5964 - 5968. [Abstract] [Full Text] [PDF] C. G. Ferreira, P. van der Valk, S. W. Span, I. Ludwig, E. F. Smit, F. A. E. Kruyt, H. M. Pinedo, H. van Tinteren, and G. Giaccone Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients Clin. Cancer Res., August 1, 2001; 7(8): 2468 - 2474. [Abstract] [Full Text] [PDF] L. Granziero, P. Ghia, P. Circosta, D. Gottardi, G. Strola, M. Geuna, L. Montagna, P. Piccoli, M. Chilosi, and F. Caligaris-Cappio Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia Blood, May 1, 2001; 97(9): 2777 - 2783. [Abstract] [Full Text] [PDF]

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