SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liyanage, M. Articles by Ried, T. Search for Related Content PubMed PubMed Citation Articles by Liyanage, M. Articles by Ried, T. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2000, Vol. 96, No. 5, pp. 1940-1946 NEOPLASIA Abnormal rearrangement within the / T-cell receptor locus in lymphomas from Atm-deficient mice Marek Liyanage, Zoë Weaver, Carrolee Barlow, Allen Coleman, Daniel G. Pankratz, Stacie Anderson, Anthony Wynshaw-Boris, and Thomas Ried From the Genome Technology Branch and Genetic Disease Research Branch, National Human Genome Research Institute; and the Genetics Department, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD. Atm-deficient mice (Atm/) recapitulate many aspects of the ataxia telangiectasia (AT) syndrome, including the susceptibility to tumors of lymphoid origin. To investigate the mechanism of tumorigenesis, we have examined a panel of 8 thymic lymphomas from Atm/ mice. All Atm/ tumors are of thymic lymphoblastoid origin, display an immature CD3 and CD4+/CD8+ phenotype, and arise coincident with V(D)J recombination. Cytogenetically, all tumors are diploid or near diploid but exhibit multiple chromosome aberrations with an average of 4 abnormal chromosomes per tumor. All the tumors revealed chromosome 14 rearrangements precisely at the T-cell receptor/ (Tcr/) locus, suggesting the involvement of V(D)J recombination in these translocations. In addition, 11.5% of Atm/ peripheral T cells showed chromosome 14 translocations, suggesting that rearrangements at the Tcr/ locus occur early during tumor development in the absence of ATM. However, additional genetic aberrations are required for tumorigenesis. For example, translocations involving chromosome 12, often with chromosome 14 (more than 60%), and partial or complete trisomy of chromosome 15, with copy number increases of the c-myc oncogene were frequently observed. These observations suggest that ATM is required for normal rearrangement of the Tcr/ locus but not for V(D)J recombination at other loci. The mechanisms that lead to tumorigenesis may be due to the involvement of ATM in monitoring double-stranded DNA breaks. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Yin, V. Savic, M. M. Juntilla, A. L. Bredemeyer, K. S. Yang-Iott, B. A. Helmink, G. A. Koretzky, B. P. Sleckman, and C. H. Bassing Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination J. Exp. Med., November 11, 2009; (2009) jem.20091320v3. [Abstract] [Full Text] G. K. Mahowald, J. M. Baron, M. A. Mahowald, S. Kulkarni, A. L. Bredemeyer, C. H. Bassing, and B. P. Sleckman Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis PNAS, October 27, 2009; 106(43): 18339 - 18344. [Abstract] [Full Text] [PDF] M. Reimann, C. Loddenkemper, C. Rudolph, I. Schildhauer, B. Teichmann, H. Stein, B. Schlegelberger, B. Dorken, and C. A. Schmitt The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo Blood, October 15, 2007; 110(8): 2996 - 3004. [Abstract] [Full Text] [PDF] Y. Dorsett, D. F. Robbiani, M. Jankovic, B. Reina-San-Martin, T. R. Eisenreich, and M. C. Nussenzweig A role for AID in chromosome translocations between c-myc and the IgH variable region J. Exp. Med., September 3, 2007; 204(9): 2225 - 2232. [Abstract] [Full Text] [PDF] K. H. Maclean, M. B. Kastan, and J. L. Cleveland Atm Deficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis Mol. Cancer Res., July 1, 2007; 5(7): 705 - 711. [Abstract] [Full Text] [PDF] M. F. Lavin, N. Gueven, S. Bottle, and R. A. Gatti Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia Br. Med. Bull., June 23, 2007; (2007) ldm012v1. [Abstract] [Full Text] [PDF] C.-Y. Huang, G. G. Sharma, L. M. Walker, C. H. Bassing, T. K. Pandita, and B. P. Sleckman Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes J. Exp. Med., June 11, 2007; 204(6): 1371 - 1381. [Abstract] [Full Text] [PDF] M. S. Vacchio, A. Olaru, F. Livak, and R. J. Hodes ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor {alpha} locus coding end breaks PNAS, April 10, 2007; 104(15): 6323 - 6328. [Abstract] [Full Text] [PDF] I. R. Matei, R. A. Gladdy, L. M. J. Nutter, A. Canty, C. J. Guidos, and J. S. Danska ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes Blood, March 1, 2007; 109(5): 1887 - 1896. [Abstract] [Full Text] [PDF] K. Ito, K. Takubo, F. Arai, H. Satoh, S. Matsuoka, M. Ohmura, K. Naka, M. Azuma, K. Miyamoto, K. Hosokawa, et al. Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes J. Immunol., January 1, 2007; 178(1): 103 - 110. [Abstract] [Full Text] [PDF] R. Reliene and R. H. Schiestl Antioxidants Suppress Lymphoma and Increase Longevity in Atm-Deficient Mice J. Nutr., January 1, 2007; 137(1): 229S - 232S. [Abstract] [Full Text] [PDF] R. V. Pusapati, R. J. Rounbehler, S. Hong, J. T. Powers, M. Yan, K. Kiguchi, M. J. McArthur, P. K. Wong, and D. G. Johnson ATM promotes apoptosis and suppresses tumorigenesis in response to Myc PNAS, January 31, 2006; 103(5): 1446 - 1451. [Abstract] [Full Text] [PDF] T.J. Bowen, H. Yakushiji, C. Montagna, S. Jain, T. Ried, and A. Wynshaw-Boris Atm Heterozygosity Cooperates with Loss of Brca1 to Increase the Severity of Mammary Gland Cancer and Reduce Ductal Branching Cancer Res., October 1, 2005; 65(19): 8736 - 8746. [Abstract] [Full Text] [PDF] C. J. Winrow, D. G. Pankratz, C. R. T. Vibat, T.J. Bowen, M. A. Callahan, A. J. Warren, B. S. Hilbush, A. Wynshaw-Boris, K. W. Hasel, Z. Weaver, et al. Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas Hum. Mol. Genet., September 15, 2005; 14(18): 2671 - 2684. [Abstract] [Full Text] [PDF] L. Erker, R. Schubert, H. Yakushiji, C. Barlow, D. Larson, J. B. Mitchell, and A. Wynshaw-Boris Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor Hum. Mol. Genet., June 15, 2005; 14(12): 1699 - 1708. [Abstract] [Full Text] [PDF] J. M. Lumsden, T. McCarty, L. K. Petiniot, R. Shen, C. Barlow, T. A. Wynn, H. C. Morse III, P. J. Gearhart, A. Wynshaw-Boris, E. E. Max, et al. Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice J. Exp. Med., November 1, 2004; 200(9): 1111 - 1121. [Abstract] [Full Text] [PDF] D. Marinkovic, T. Marinkovic, E. Kokai, T. Barth, P. Moller, and T. Wirth Identification of novel Myc target genes with a potential role in lymphomagenesis Nucleic Acids Res., October 11, 2004; 32(18): 5368 - 5378. [Abstract] [Full Text] [PDF] R. Schubert, L. Erker, C. Barlow, H. Yakushiji, D. Larson, A. Russo, J. B. Mitchell, and A. Wynshaw-Boris Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice Hum. Mol. Genet., August 15, 2004; 13(16): 1793 - 1802. [Abstract] [Full Text] [PDF] L. Qi, M. A. Strong, B. O. Karim, M. Armanios, D. L. Huso, and C. W. Greider Short Telomeres and Ataxia-Telangiectasia Mutated Deficiency Cooperatively Increase Telomere Dysfunction and Suppress Tumorigenesis Cancer Res., December 1, 2003; 63(23): 8188 - 8196. [Abstract] [Full Text] [PDF] Q. Pan-Hammarstrom, S. Dai, Y. Zhao, I. F. van Dijk-Hard, R. A. Gatti, A.-L. Borresen-Dale, and L. Hammarstrom ATM Is Not Required in Somatic Hypermutation of VH, but Is Involved in the Introduction of Mutations in the Switch {micro} Region J. Immunol., April 1, 2003; 170(7): 3707 - 3716. [Abstract] [Full Text] [PDF] M. Yan, X. Kuang, W. Qiang, J. Shen, K. Claypool, W. S. Lynn, and P. K. Y. Wong Prevention of Thymic Lymphoma Development in Atm-/- Mice by Dexamethasone Cancer Res., September 15, 2002; 62(18): 5153 - 5157. [Abstract] [Full Text] [PDF] M. J. Difilippantonio, S. Petersen, H. T. Chen, R. Johnson, M. Jasin, R. Kanaar, T. Ried, and A. Nussenzweig Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification J. Exp. Med., August 19, 2002; 196(4): 469 - 480. [Abstract] [Full Text] [PDF] L. K. Petiniot, Z. Weaver, M. Vacchio, R. Shen, D. Wangsa, C. Barlow, M. Eckhaus, S. M. Steinberg, A. Wynshaw-Boris, T. Ried, et al. RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice Mol. Cell. Biol., May 1, 2002; 22(9): 3174 - 3177. [Abstract] [Full Text] [PDF] E. J. Perkins, A. Nair, D. O. Cowley, T. Van Dyke, Y. Chang, and D. A. Ramsden Sensing of intermediates in V(D)J recombination by ATM Genes & Dev., January 15, 2002; 16(2): 159 - 164. [Abstract] [Full Text] [PDF] T. Stankovic, G. S. Stewart, C. Fegan, P. Biggs, J. Last, P. J. Byrd, R. D. Keenan, P. A. H. Moss, and A. M. R. Taylor Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage Blood, January 1, 2002; 99(1): 300 - 309. [Abstract] [Full Text] [PDF] M. YAN, W. QIANG, N. LIU, J. SHEN, W. S. LYNN, and P. K. Y. WONG The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes FASEB J, May 1, 2001; 15(7): 1132 - 1138. [Abstract] [Full Text] [PDF] L. Resor, T. J. Bowen, and A. Wynshaw-Boris Unraveling human cancer in the mouse: recent refinements to modeling and analysis Hum. Mol. Genet., April 1, 2001; 10(7): 669 - 675. [Abstract] [Full Text] [PDF] D. M. Allen, H. van Praag, J. Ray, Z. Weaver, C. J. Winrow, T. A. Carter, R. Braquet, E. Harrington, T. Ried, K. D. Brown, et al. Ataxia telangiectasia mutated is essential during adult neurogenesis Genes & Dev., March 1, 2001; 15(5): 554 - 566. [Abstract] [Full Text] H. T. Chen, A. Bhandoola, M. J. Difilippantonio, J. Zhu, M. J. Brown, X. Tai, E. P. Rogakou, T. M. Brotz, W. M. Bonner, T. Ried, et al. Response to RAG-Mediated V(D)J Cleavage by NBS1 and {gamma}-H2AX Science, December 8, 2000; 290(5498): 1962 - 1964. [Abstract] [Full Text]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020