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Blood, 15 September 2000, Vol. 96, No. 6, pp. 2037-2044
REVIEW ARTICLE
Solitary plasmacytoma of bone and asymptomatic multiple
myeloma
Meletios A. Dimopoulos,
Lia
A. Moulopoulos,
Alice Maniatis, and
Raymond Alexanian
From the Departments of Clinical Therapeutics and
Radiology, University of Athens School of Medicine, Athens, Greece; the
Department of Laboratory Hematology and Transfusion Medicine,
University of Patras School of Medicine, Patras, Greece; and the
Department of Lymphoma and Myeloma, University of Texas MD Anderson
Cancer Center, Houston, TX.
Most patients with multiple myeloma (MM) present with symptoms,
have evidence of generalized disease, and require chemotherapy promptly
to reduce the malignant clone. Some patients present with a local
symptom from a single plasmacytoma but no myeloma elsewhere. Such
patients usually become free of symptoms after local radiotherapy. In
patients with MM without symptoms, the diagnosis is made on the basis
of screening laboratory tests. In patients with either solitary
plasmacytoma of bone or asymptomatic MM, systemic treatment should
be deferred until there is evidence of disease progression.
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