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Related Collections Immunobiology Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2000, Vol. 96, No. 6, pp. 2069-2073 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients Eric Oksenhendler, Guislaine Carcelain, Yoshiyasu Aoki, Emmanuelle Boulanger, Anne Maillard, Jean-Pierre Clauvel, and Félix Agbalika From the Department of Immunology and Hematology, Laboratory of Virology, Hôpital Saint-Louis, Paris, France; Laboratory of Immunology, Hôpital Pitié-Salpétrière, Paris, France; and Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-induced clinical remission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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