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Blood, 15 September 2000, Vol. 96, No. 6, pp. 2069-2073
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
High levels of human herpesvirus 8 viral load, human
interleukin-6, interleukin-10, and C reactive protein correlate with
exacerbation of multicentric Castleman disease in
HIV-infected patients
Eric Oksenhendler,
Guislaine Carcelain,
Yoshiyasu Aoki,
Emmanuelle Boulanger,
Anne Maillard,
Jean-Pierre Clauvel, and
Félix Agbalika
From the Department of Immunology and Hematology,
Laboratory of Virology, Hôpital Saint-Louis, Paris, France;
Laboratory of Immunology, Hôpital
Pitié-Salpétrière, Paris, France; and Medicine
Branch, National Cancer Institute, National Institutes of Health,
Bethesda, MD.
Multicentric Castleman disease (MCD) is a distinct type of
lymphoproliferative disorder associated with inflammatory symptoms and
interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human
herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present
at 45 visits, whereas patients were in chemotherapy-induced clinical
remission at 50 visits. Symptoms were associated with a high level of
serum C reactive protein, high HHV8 viral load in peripheral blood
mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong
correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral
load suggest that both cytokines may be involved in the pathogenesis of
this virus-associated lymphoproliferative disorder.
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