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Blood, 15 September 2000, Vol. 96, No. 6, pp. 2081-2083
HEMATOPOIESIS
Depressed immunity and impaired proliferation of hematopoietic
progenitor cells in patients with complete spinal cord injury
Per Ole Iversen,
Nils Hjeltnes,
Bjørn Holm,
Torun Flatebø,
Inger Strøm-Gundersen,
Wenche Rønning,
Johan Stanghelle, and
Haakon B. Benestad
From the Department of Physiology, Institute of Basic
Medical Sciences, University of Oslo; the Department of Medicine,
Lovisenberg Hospital, Oslo; and Sunnaas Hospital, Nesoddtangen, Norway.
The bone marrow is supplied with both sensory and autonomic
neurons, but their roles in regulating hematopoietic and
immunocompetent cells are unknown. Leukocyte growth and activity in
patients with stable and complete spinal cord injuries were studied.
The innervation of the bone marrow below the injury level lacked normal
supraspinal activity, that is, a decentralized bone marrow. Lymphocyte
functions were markedly decreased in injured patients. Long-term colony formation of all hematopoietic cell lineages, including dendritic cells, by decentralized bone marrow cells was substantially reduced. It
was concluded that nonspecific and adaptive lymphocyte-mediated immunity and growth of early hematopoietic progenitor cells are impaired in patients with spinal cord injuries. Possibly, this reflects
cellular defects caused by the malfunctioning neuronal regulation of
immune and bone marrow function.
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