SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bheekha-Escura, R. Articles by MacDonald, S. M. Search for Related Content PubMed PubMed Citation Articles by Bheekha-Escura, R. Articles by MacDonald, S. M. Related Collections Immunobiology Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2000, Vol. 96, No. 6, pp. 2191-2198 IMMUNOBIOLOGY Human recombinant histamine-releasing factor activates human eosinophils and the eosinophilic cell line, AML14-3D10 Roy Bheekha-Escura, Donald W. MacGlashan Jr, Jacqueline M. Langdon, and Susan M. MacDonald From The Johns Hopkins Asthma and Allergy Center, Baltimore, MD. The human recombinant histamine-releasing factor (HrHRF) was previously shown to induce histamine release from human basophils from a subset of donors. The ability of HrHRF to directly induce histamine release from only certain basophils was thought to involve interaction between HrHRF and a particular kind of IgE, termed IgE+, on the surface of these cells. Recent studies disproved the hypothesis that the IgE molecule or its high-affinity receptor, FcRI, is involved in secretion of histamine and cytokines by basophils stimulated with HrHRF. Rather, data suggest that HrHRF is a cytokine that stimulates basophils by binding to a cell-surface structure other than the IgE molecule. This report describes the effects of HrHRF on another inflammatory cell type: eosinophils from mildly allergic donors. In purified eosinophils primed with granulocyte-macrophage colony-stimulating factor, both tumor necrosis factor  (TNF-) and HrHRF induced increased secretion of interleukin (IL) 8. In addition, both HrHRF and IL-5 enhanced secretion of IL-8 stimulated by TNF-. Secretion of IL-8 reached a plateau level in less than 24 hours, was inhibited by cycloheximide, and required the presence of HrHRF throughout the culture period. In some eosinophil preparations, HrHRF induced calcium mobilization that was inhibited by pertussis toxin. Additionally, HrHRF caused secretion of IL-8 from the human eosinophilic cell line, AML14-3D10, which does not possess the  chain of FcRI. These data provide evidence that HrHRF contributes to activation of eosinophils and thus suggest an additional role for HrHRF in the pathophysiologic mechanisms of allergic disease. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Y. Feng, S. C. Johnson, T. S. Hori, M. Rise, J. R. Hall, A. K. Gamperl, S. Hubert, J. Kimball, S. Bowman, and M. L. Rise Identification and analysis of differentially expressed genes in immune tissues of Atlantic cod stimulated with formalin-killed, atypical Aeromonas salmonicida Physiol Genomics, May 13, 2009; 37(3): 149 - 163. [Abstract] [Full Text] [PDF] J. M. Langdon, J. T. Schroeder, B. M. Vonakis, A. P. Bieneman, K. Chichester, and S. M. MacDonald Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models J. Leukoc. Biol., October 1, 2008; 84(4): 1151 - 1158. [Abstract] [Full Text] [PDF] B. M. Vonakis, D. W. MacGlashan Jr, N. Vilarino, J. M. Langdon, R. S. Scott, and S. M. MacDonald Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced priming and activation of human basophils Blood, February 15, 2008; 111(4): 1789 - 1796. [Abstract] [Full Text] [PDF] C. E. Demeure, K. Brahimi, F. Hacini, F. Marchand, R. Peronet, M. Huerre, P. St.-Mezard, J.-F. Nicolas, P. Brey, G. Delespesse, et al. Anopheles Mosquito Bites Activate Cutaneous Mast Cells Leading to a Local Inflammatory Response and Lymph Node Hyperplasia J. Immunol., April 1, 2005; 174(7): 3932 - 3940. [Abstract] [Full Text] [PDF] K. Yoneda, K. Rokutan, Y. Nakamura, H. Yanagawa, S. Kondo-Teshima, and S. Sone Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L174 - L181. [Abstract] [Full Text] [PDF] B. M. Vonakis, R. Sora, J. M. Langdon, V. Casolaro, and S. M. MacDonald Inhibition of Cytokine Gene Transcription by the Human Recombinant Histamine-Releasing Factor in Human T Lymphocytes J. Immunol., October 1, 2003; 171(7): 3742 - 3750. [Abstract] [Full Text] [PDF] K. V. N. Rao, L. Chen, M. Gnanasekar, and K. Ramaswamy Cloning and Characterization of a Calcium-binding, Histamine-releasing Protein from Schistosoma mansoni J. Biol. Chem., August 16, 2002; 277(34): 31207 - 31213. [Abstract] [Full Text] [PDF] S. M. MacDonald, J. Bhisutthibhan, T. A. Shapiro, S. J. Rogerson, T. E. Taylor, M. Tembo, J. M. Langdon, and S. R. Meshnick Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo PNAS, September 4, 2001; (2001) 201191498. [Abstract] [Full Text] [PDF] S. M. MacDonald, J. Bhisutthibhan, T. A. Shapiro, S. J. Rogerson, T. E. Taylor, M. Tembo, J. M. Langdon, and S. R. Meshnick Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo PNAS, September 11, 2001; 98(19): 10829 - 10832. [Abstract] [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020