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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Krzysiek, R. Articles by Richard, Y. Search for Related Content PubMed PubMed Citation Articles by Krzysiek, R. Articles by Richard, Y. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 October 2000, Vol. 96, No. 7, pp. 2338-2345 CHEMOKINES Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3/CCL20 in human B cells Roman Krzysiek, Eric A. Lefevre, Jérôme Bernard, Arnaud Foussat, Pierre Galanaud, Fawzia Louache, and Yolande Richard From the Institut National de la Santé et de la Recherche Médicale (INSERM) U 131, Institut Paris-Sud sur les Cytokines, Clamart, France; and INSERM U 362, Institut Gustave Roussy, Villejuif, France. The regulation of CCR6 (chemokine receptor 6) expression during B-cell ontogeny and antigen-driven B-cell differentiation was analyzed. None of the CD34+Lin hematopoietic stem cell progenitors or the CD34+CD19+ (pro-B) or the CD19+CD10+ (pre-B/immature B cells) B-cell progenitors expressed CCR6. CCR6 is acquired when CD10 is lost and B-cell progeny matures, entering into the surface immunoglobulin D+ (sIgD+) mature B-cell pool. CCR6 is expressed by all bone marrow-, umbilical cord blood-, and peripheral blood-derived naive and/or memory B cells but is absent from germinal center (GC) B cells of secondary lymphoid organs. CCR6 is down-regulated after B-cell antigen receptor triggering and remains absent during differentiation into immunoglobulin-secreting plasma cells, whereas it is reacquired at the stage of post-GC memory B cells. Thus, within the B-cell compartment, CCR6 expression is restricted to functionally mature cells capable of responding to antigen challenge. In transmigration chemotactic assays, macrophage inflammatory protein (MIP)-3/CC chemokine ligand 20 (CCL20) induced vigorous migration of B cells with differential chemotactic preference toward sIgD memory B cells. These data suggest that restricted patterns of CCR6 expression and MIP-3/CCL20 responsiveness are integral parts of the process of B-lineage maturation and antigen-driven B-cell differentiation. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Liston, R. E. Kohler, S. Townley, S. 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