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Blood, 1 October 2000, Vol. 96, No. 7, pp. 2543-2549
NEOPLASIA
New recurring cytogenetic abnormalities and association of blast
cell karyotypes with prognosis in childhood T-cell acute lymphoblastic
leukemia: a Pediatric Oncology Group report of 343 cases
Nancy R. Schneider,
Andrew
J. Carroll,
Jonathan J. Shuster,
D. Jeanette Pullen,
Michael P. Link,
Michael J. Borowitz,
Bruce
M. Camitta,
Julie A. Katz, and
Michael D. Amylon
From the University of Texas Southwestern Medical
Center, Dallas, TX; the University of Alabama, Birmingham, AL; The
Pediatric Oncology Group Statistical Office at The University of
Florida, Gainesville, FL; the University of Mississippi Medical Center,
Jackson, MS; Lucille Packard Children's Hospital, Stanford University
Medical Center, Stanford, CA; Johns Hopkins University Medical School,
Baltimore, MD; the Midwest Children's Cancer Center at the Medical
College of Wisconsin, Milwaukee, WI.
To further define the cytogenetic differences between B-cell
lineage (B-lineage) acute lymphoblastic leukemia (ALL) and T-cell lineage ALL (T-ALL) and to determine the prognostic value of
cytogenetics in childhood T-ALL, the blast cell karyotypes of 343 cases
of pediatric T-ALL, the largest series reported to date, were
evaluated. Cytogenetics were performed in a single central laboratory,
and the children were treated using a single Pediatric Oncology Group protocol. Clear differences between the karyotypic characteristics of
B-lineage ALL and T-ALL were confirmed. This study
suggests that there may be survival differences associated with some
T-ALL blast cell karyotypes. Better survival is associated with only normal karyotypes and with t(10;14) (translocation of chromosomes 10 and 14); worse survival is associated with the presence of any
derivative chromosome. Two new recurring chromosome aberrations previously not reported in T-ALL were found: del(1)(p22) and
t(8;12)(q13;p13). Ten aberrations found in this series, which were
reported only once previously in T-ALL, can now be considered recurring
abnormalities in T-ALL. All 12 of these new recurring aberrations are
targets for discovery and characterization of new genes that are
important in T-cell development and leukemogenesis.
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