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Blood, 1 October 2000, Vol. 96, No. 7, pp. 2621-2627
TRANSFUSION MEDICINE
Identification of the Dombrock blood group glycoprotein as a
polymorphic member of the ADP-ribosyltransferase gene family
Alexander N. Gubin,
J.
Muthoni Njoroge,
Urszula Wojda,
Svetlana D. Pack,
Maria Rios,
Marion E. Reid, and
Jeffery L. Miller
From the Laboratory of Chemical Biology, National
Institute of Diabetes and Digestive and Kidney Diseases, and the
Surgical Neurology Branch, National Institute of Neurological Disorders
and Stroke, National Institutes of Health, Bethesda, MD, and the
Department of Immunochemistry, New York Blood Center, New York, NY.
Identification of the 25 known human blood group molecules is of
fundamental importance for the fields of erythroid cell biology and
transfusion medicine. Here we provide the first molecular description
of the "Dombrock" blood group system. A candidate gene was
identified by in silico analyses of approximately 5000 expressed
sequence tags (ESTs) from terminally differentiating human erythroid
cells. Transfection experiments demonstrated specific binding of
anti-Dombrock and confirmed glycosylphosphatidylinositol membrane
attachment. Dombrock expression is developmentally regulated during
erythroid differentiation and occurs at highest levels in the fetal
liver. Homology studies suggest that the Dombrock molecule is a member
of the adenosine 5'-diphosphate (ADP)-ribosyltransferase ectoenzyme gene family. Genotypic comparisons suggest
Doa versus Dob antigenicity results
from a single amino acid substitution within an encoded
arginine-glycine-aspartic acid (RGD) motif of the molecule.
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