|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 October 2000, Vol. 96, No. 8, pp. 2664-2672
REVIEW ARTICLE
Antimicrobial proteins and peptides of blood: templates for
novel antimicrobial agents
Ofer Levy
From the Division of Infectious Disease, The
Children's Hospital, Boston, MA.
The innate immune system provides rapid and effective host defense
against microbial invasion in a manner that is independent of prior
exposure to a given pathogen.1 It has long been
appreciated that the blood contains important elements that mediate
rapid responses to infection. Thus, anatomic compartments with ample
blood supply are less frequently infected and recover more readily once
infected, whereas regions with poor perfusion are prone to severe
infection and may require surgical débridement. Blood-borne
innate immune mediators are either carried in circulating blood cells
(ie, leukocytes and platelets) or in plasma after release from blood
cells or on secretion by the liver.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
O. Haworth and B. D. Levy
Endogenous lipid mediators in the resolution of airway inflammation
Eur. Respir. J.,
November 1, 2007;
30(5):
980 - 992.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Jang, S.-C. Lee, Y. S. Lee, Y. P. Shin, K. H. Shin, B. H. Sung, B. S. Kim, S. H. Lee, and I. H. Lee
Antimicrobial Effect of Halocidin-Derived Peptide in a Mouse Model of Listeria Infection
Antimicrob. Agents Chemother.,
November 1, 2007;
51(11):
4148 - 4156.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Tsuji, B. Battsetseg, D. Boldbaatar, T. Miyoshi, X. Xuan, J. H. Oliver Jr., and K. Fujisaki
Babesial Vector Tick Defensin against Babesia sp. Parasites
Infect. Immun.,
July 1, 2007;
75(7):
3633 - 3640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Radzishevsky, M. Krugliak, H. Ginsburg, and A. Mor
Antiplasmodial Activity of Lauryl-Lysine Oligomers
Antimicrob. Agents Chemother.,
May 1, 2007;
51(5):
1753 - 1759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. E. Lopez, P. A. Vincent, A. M. Zenoff, R. A. Salomon, and R. N. Farias
Efficacy of microcin J25 in biomatrices and in a mouse model of Salmonella infection
J. Antimicrob. Chemother.,
April 1, 2007;
59(4):
676 - 680.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. H. S. Kwakman, A. A. te Velde, C. M. J. E. Vandenbroucke-Grauls, S. J. H. van Deventer, and S. A. J. Zaat
Treatment and Prevention of Staphylococcus epidermidis Experimental Biomaterial-Associated Infection by Bactericidal Peptide 2
Antimicrob. Agents Chemother.,
December 1, 2006;
50(12):
3977 - 3983.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Okuda, S. Yomogida, H. Tamura, and I. Nagaoka
Determination of the Antibacterial and Lipopolysaccharide-Neutralizing Regions of Guinea Pig Neutrophil Cathelicidin Peptide CAP11.
Antimicrob. Agents Chemother.,
August 1, 2006;
50(8):
2602 - 2607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lukasiewicz, T. Niedziela, W. Jachymek, L. Kenne, and C. Lugowski
Structure of the lipid A-inner core region and biological activity of Plesiomonas shigelloides O54 (strain CNCTC 113/92) lipopolysaccharide
Glycobiology,
June 1, 2006;
16(6):
538 - 550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Cho, I. P. Fraser, K. Fukase, S. Kusumoto, Y. Fujimoto, G. L. Stahl, and R. A. B. Ezekowitz
Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity
Blood,
October 1, 2005;
106(7):
2551 - 2558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. S. Radzishevsky, S. Rotem, F. Zaknoon, L. Gaidukov, A. Dagan, and A. Mor
Effects of Acyl versus Aminoacyl Conjugation on the Properties of Antimicrobial Peptides
Antimicrob. Agents Chemother.,
June 1, 2005;
49(6):
2412 - 2420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lennartsson, K. Pieters, K. Vidovic, and U. Gullberg
A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow
J. Leukoc. Biol.,
March 1, 2005;
77(3):
369 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Levy
Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes
J. Leukoc. Biol.,
November 1, 2004;
76(5):
909 - 925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Balaban, Y. Gov, A. Giacometti, O. Cirioni, R. Ghiselli, F. Mocchegiani, F. Orlando, G. D'Amato, V. Saba, G. Scalise, et al.
A Chimeric Peptide Composed of a Dermaseptin Derivative and an RNA III-Inhibiting Peptide Prevents Graft-Associated Infections by Antibiotic-Resistant Staphylococci
Antimicrob. Agents Chemother.,
July 1, 2004;
48(7):
2544 - 2550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ohgami, I. B. Ilieva, K. Shiratori, E. Isogai, K. Yoshida, S. Kotake, T. Nishida, N. Mizuki, and S. Ohno
Effect of Human Cationic Antimicrobial Protein 18 Peptide on Endotoxin-Induced Uveitis in Rats
Invest. Ophthalmol. Vis. Sci.,
October 1, 2003;
44(10):
4412 - 4418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Yeaman, K. D. Gank, A. S. Bayer, and E. P. Brass
Synthetic Peptides That Exert Antimicrobial Activities in Whole Blood and Blood-Derived Matrices
Antimicrob. Agents Chemother.,
December 1, 2002;
46(12):
3883 - 3891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Nagaoka, S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, S. Tanaka, and D. Heumann
Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues
Clin. Vaccine Immunol.,
September 1, 2002;
9(5):
972 - 982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. McCabe, T. Cukierman, and J. E. Gabay
Basic Residues in Azurocidin/HBP Contribute to Both Heparin Binding and Antimicrobial Activity
J. Biol. Chem.,
July 19, 2002;
277(30):
27477 - 27488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Efron, A. Dagan, L. Gaidukov, H. Ginsburg, and A. Mor
Direct Interaction of Dermaseptin S4 Aminoheptanoyl Derivative with Intraerythrocytic Malaria Parasite Leading to Increased Specific Antiparasitic Activity in Culture
J. Biol. Chem.,
June 28, 2002;
277(27):
24067 - 24072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Kustanovich, D. E. Shalev, M. Mikhlin, L. Gaidukov, and A. Mor
Structural Requirements for Potent Versus Selective Cytotoxicity for Antimicrobial Dermaseptin S4 Derivatives
J. Biol. Chem.,
May 3, 2002;
277(19):
16941 - 16951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dagan, L. Efron, L. Gaidukov, A. Mor, and H. Ginsburg
In Vitro Antiplasmodium Effects of Dermaseptin S4 Derivatives
Antimicrob. Agents Chemother.,
April 1, 2002;
46(4):
1059 - 1066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Canny, O. Levy, G. T. Furuta, S. Narravula-Alipati, R. B. Sisson, C. N. Serhan, and S. P. Colgan
Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia
PNAS,
March 19, 2002;
99(6):
3902 - 3907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Navon-Venezia, R. Feder, L. Gaidukov, Y. Carmeli, and A. Mor
Antibacterial Properties of Dermaseptin S4 Derivatives with In Vivo Activity
Antimicrob. Agents Chemother.,
March 1, 2002;
46(3):
689 - 694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jankowski, C. C. Scott, and S. Grinstein
Determinants of the Phagosomal pH in Neutrophils
J. Biol. Chem.,
February 15, 2002;
277(8):
6059 - 6066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Nagaoka, S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, and D. Heumann
Cathelicidin Family of Antibacterial Peptides CAP18 and CAP11 Inhibit the Expression of TNF-{alpha} by Blocking the Binding of LPS to CD14+ Cells
J. Immunol.,
September 15, 2001;
167(6):
3329 - 3338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Ginsburg
Cationic peptides from leukocytes might kill bacteria by activating their autolytic enzymes causing bacteriolysis: why are publications proposing this concept never acknowledged?
Blood,
April 15, 2001;
97(8):
2530 - 2532.
[Full Text]
[PDF]
|
|
|
| |
